Numerical simulation of nanoparticles assisted laser photothermal therapy: a comparison of the P1‐approximation and discrete ordinate methods

Maurente, André Jesus Soares; Bruno, Alexandre Barbosa; Lamien, Bernard; Orlande, Helcio R. B.

Numerical simulation of nanoparticles assisted laser photothermal therapy: a comparison of the P1‐approximation and discrete ordinate methods

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dc.contributor.author	Maurente, André Jesus Soares
dc.contributor.author	Bruno, Alexandre Barbosa
dc.contributor.author	Lamien, Bernard
dc.contributor.author	Orlande, Helcio R. B.
dc.date.accessioned	2021-03-11T21:18:00Z
dc.date.available	2021-03-11T21:18:00Z
dc.date.issued	2016-05-05
dc.description.resumo	Photothermal therapy (PTT) with combined use of laser radiation and photon absorber nanoparticles is a promising technique to treat cancer. Treatment planning and devising appropriate protocols for cancer photo thermal therapy require the computational simulation of coupled physical phenomena, such as radiation, conduction, and blood perfusion. The P1-approximation is a numerical method to solve radiation heat transfer which features the advantage of being computationally fast and, therefore, desirable for PTT simulations. However, the method is known to become inaccurate under certain conditions. In this study, the P1-approximation and the accurate discrete ordinate method were applied to solve a set of test problems idealized to portray conditions encountered in PTT. The test problems were one-dimensional, and the radiation scattering was assumed as isotropic. Tissues composed by layers with different properties were considered, including cases in which gold nanoparticles were embedded in the tissue to increase photon absorption. For the problems considered here, the P1-approximation and discrete ordinate method results presented quite good agreement for the time-dependent temperature distribution, which is the quantity of interest in PTT	pt_BR
dc.identifier.citation	BRUNO, Alexandre B.; MAURENTE, André; LAMIEN, Bernard; ORLANDE, Helcio R. B.. Numerical simulation of nanoparticles assisted laser photothermal therapy: a comparison of the p1-approximation and discrete ordinate methods. Journal of The Brazilian Society of Mechanical Sciences And Engineering, [S.L.], v. 39, n. 2, p. 621-630, 5 maio 2016. Disponível em: https://link.springer.com/article/10.1007/s40430-016-0553-3. Acesso em: 22 out. 2020. http://dx.doi.org/10.1007/s40430-016-0553-3.	pt_BR
dc.identifier.doi	10.1007/s40430-016-0553-3
dc.identifier.issn	1678-5878
dc.identifier.issn	1806-3691
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31817
dc.language	en	pt_BR
dc.publisher	Springer	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Photothermal therapy	pt_BR
dc.subject	Heat transfer simulation	pt_BR
dc.subject	Coupled radiation-conduction-blood perfusion	pt_BR
dc.subject	P1-approximation	pt_BR
dc.subject	Discrete ordinate method	pt_BR
dc.title	Numerical simulation of nanoparticles assisted laser photothermal therapy: a comparison of the P1‐approximation and discrete ordinate methods	pt_BR
dc.type	article	pt_BR