FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma

Peterle, G. T.; Santos, Marcelo dos; Mendes, S. O.; Carvalho-Neto, P. B.; Maia, L. L.; Stur, E.; Agostini, Lidiane Pignaton; Silva, C. V. M.; Trivilin, L. O.; Nunes, F. D.; Carvalho, M. B.; Tajara, E. H.; Louro, I. D.; Silva-Conforti, A. M. A.

FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma

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dc.contributor.author	Peterle, G. T.
dc.contributor.author	Santos, Marcelo dos
dc.contributor.author	Mendes, S. O.
dc.contributor.author	Carvalho-Neto, P. B.
dc.contributor.author	Maia, L. L.
dc.contributor.author	Stur, E.
dc.contributor.author	Agostini, Lidiane Pignaton
dc.contributor.author	Silva, C. V. M.
dc.contributor.author	Trivilin, L. O.
dc.contributor.author	Nunes, F. D.
dc.contributor.author	Carvalho, M. B.
dc.contributor.author	Tajara, E. H.
dc.contributor.author	Louro, I. D.
dc.contributor.author	Silva-Conforti, A. M. A.
dc.date.accessioned	2021-02-09T17:29:43Z
dc.date.available	2021-02-09T17:29:43Z
dc.date.issued	2015-09-22
dc.description.resumo	Currently, the most important prognostic factor in oral squamous cell carcinoma (OSCC) is the presence of regional lymph node metastases, which correlates with a 50% reduction in life expectancy. We have previously observed that expression of hypoxia genes in the tumor inflammatory infiltrate is statistically related to prognosis in OSCC. FAS and FASL expression levels in OSCC have previously been related to patient survival. The present study analyzed the relationship between FASL expression in the inflammatory infiltrate lymphoid cells and clinical variables, tumor histology, and prognosis of OSCC. Strong FASL expression was significantly associated with lymph node metastases (P = 0.035) and disease-specific death (P = 0.014), but multivariate analysis did not confirm FASL expression as an independent death risk factor (OR = 2.78, 95%CI = 0.81-9.55). Diseasefree and disease-specific survival were significantly correlated with FASL expression (P = 0.016 and P = 0.005, respectively). Multivariate analysis revealed that strong FASL expression is an independent marker for earlier disease relapse and disease-specific death, with approximately 2.5-fold increased risk compared with weak expression (HR = 2.24, 95%CI = 1.08-4.65 and HR = 2.49, 95%CI = 1.04-5.99, respectively). Our results suggest a potential role for this expression profile as a tumor prognostic marker in OSCC patients	pt_BR
dc.identifier.citation	PETERLE, G. T. et al. FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma. Genetics and Molecular Research, [s. l.], v. 14, n. 3 p. 11145-11153, 2015. Disponível em: https://www.geneticsmr.org/articles/fas-ligand-expression-in-inflammatory-infiltrate-lymphoid-cells-as-a-prognostic-marker-in-oral-squamous-cell-carcinoma.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.September.22.8	pt_BR
dc.identifier.doi	10.4238/2015.September.22.8
dc.identifier.issn	1676-5680 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31433
dc.language	en	pt_BR
dc.publisher	Fundação de Pesquisas de Ribeirão Preto	pt_BR
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/br/	*
dc.subject	FASL expression	pt_BR
dc.subject	Lymphoid cells	pt_BR
dc.subject	Oral cancer	pt_BR
dc.subject	Inflammatory infiltrate	pt_BR
dc.subject	Prognostic marker	pt_BR
dc.title	FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma	pt_BR
dc.type	article	pt_BR