Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons
| dc.contributor.author | Dettogni, Raquel Spinassé | |
| dc.contributor.author | Tristão-Sá, Ricardo | |
| dc.contributor.author | Santos, Marcelo dos | |
| dc.contributor.author | Silva, Franciane Figueiredo da | |
| dc.contributor.author | Louro, Iúri Drumond | |
| dc.date.accessioned | 2021-02-19T10:18:14Z | |
| dc.date.available | 2021-02-19T10:18:14Z | |
| dc.date.issued | 2015 | |
| dc.description.resumo | This study was undertaken to determine the prevalence of dengue clinical symptom persistence during 60 days of disease follow up, in patients of Espírito Santo state (ES)-Brazil and to evaluate the relation of single nucleotide polymorphisms (SNPs) in FccRIIa, CD209, VDR, TNF-a, IL-4, IL-6 and IFN-c genes with symptom persistence. During 2012–2013, 96 blood samples from individuals diagnosed with symptomatic dengue were collected. Clinical symptom persistence in 60 days of follow-up was assessed by a clinical and epidemiological questionnaire filled in 4 interviews. SNP genotyping was performed by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). In two months of monitoring the dengue infection, we observed that symptoms persisted in 38.5% (37/96) of dengue patients at the end of the first month (D30) and in 11.5% (11/96) of dengue patients at the end of the second month (D60). Our results show an association between FccRIIa, TNF-a and IL-6 gene SNPs and symptom persistence and an association trend with CD209, IL-4 and IFN-c gene SNPs. Our findings may increase the knowledge on the pathophysiological mechanisms of persistent symptoms of infection with the dengue virus (DENV) and thus help the clinical management of patients | pt_BR |
| dc.identifier.citation | DETTOGNI, Raquel Spinassé; TRISTAO-SA, Ricardo; SANTOS, Marcelo dos; SILVA, Franciane Figueiredo da; LOURO, Iúri Drumond. Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons. Human Immunology, [s. l.], v. 76, n. 10, p. 717-723, 2015. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0198885915004632?via%3Dihub. Acesso em: 07 jul. 2020. https://doi.org/10.1016/j.humimm.2015.09.026 | pt_BR |
| dc.identifier.doi | 10.1016/j.humimm.2015.09.026 | |
| dc.identifier.issn | 0198-8859 (print) | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/31559 | |
| dc.language | en | pt_BR |
| dc.publisher | Elsevier | pt_BR |
| dc.subject | Immune system SNPs | pt_BR |
| dc.subject | Receptors | pt_BR |
| dc.subject | Cytokines | pt_BR |
| dc.subject | Dengue | pt_BR |
| dc.subject | Symptoms persistent | pt_BR |
| dc.title | Single nucleotide polymorphisms in immune system genes and their association with clinical symptoms persistence in dengue-infected persons | pt_BR |
| dc.type | article | pt_BR |
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