Avaliação das citocinas na doença hepática gordurosa não alcoólica: uma revisão da literatura

Abstract

Non-alcoholic fatty liver disease (NAFLD) has become a rising challenge for public health around the world and it is causally related to the inflammation of adipose tissue. In this context, it is known that cytokines especially pro-inflammatory, Interleukin (IL-1) and tumor necrosis factor (TNF-α) are involved in this process. The purpose of this literature review was to analyze the profile of these cytokines in patients with NAFLD. To this end, 4503 articles were analyzed in the following databases: PubMed and Science Direct using this keywords: “nafld and anti-inflammatory cytokines”; “NAFLD” AND “cytokines”; “NAFLD” AND “IFN”; “NAFLD” AND “IL-2”; “NAFLD” AND “IL-10”; “NAFLD” AND “IL-1”; “NAFLD” AND “IL-6”; “NAFLD” AND “TNF”. At end, after analysis by title, abstract and all text, 4 articles are included were observed an elevation profile of cytokines IL-6 and TNFα. Thus, although the pathophysiology is not well described, the study of the pro-inflammatory cytokine profile directs the development of future interventions.