Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities

Camara, Rafael Barros Gomes; Costa, Leandro Silva; Fidelis, Gabriel Pereira; Nobre, Leonardo Thiago Duarte Barreto; Dantas-Santos, Nednaldo; Cordeiro, Sara Lima; Costa, Mariana Santana Santos Pereira; Alves, Luciana Guimaraes; Rocha, Hugo Alexandre de Oliveira

Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities

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dc.contributor.author	Camara, Rafael Barros Gomes
dc.contributor.author	Costa, Leandro Silva
dc.contributor.author	Fidelis, Gabriel Pereira
dc.contributor.author	Nobre, Leonardo Thiago Duarte Barreto
dc.contributor.author	Dantas-Santos, Nednaldo
dc.contributor.author	Cordeiro, Sara Lima
dc.contributor.author	Costa, Mariana Santana Santos Pereira
dc.contributor.author	Alves, Luciana Guimaraes
dc.contributor.author	Rocha, Hugo Alexandre de Oliveira
dc.date.accessioned	2021-01-29T17:38:37Z
dc.date.available	2021-01-29T17:38:37Z
dc.date.issued	2011-01-24
dc.description.resumo	Fucan is a term used to denominate a family of sulfated polysaccharides rich in sulfated L-fucose. We extracted six fucans from Canistrocarpus cervicornis by proteolytic digestion followed by sequential acetone precipitation. These heterofucans are composed mainly of fucose, glucuronic acid, galactose and sulfate. No polysaccharide was capable of prolonging prothrombin time (PT) at the concentration assayed. However, all polysaccharides prolonged activated partial thromboplastin time (aPTT). Four sulfated polysaccharides (CC-0.3/CC-0.5/CC-0.7/CC-1.0) doubled aPTT with only 0.1 mg/mL of plasma, only 1.25-fold less than Clexane®, a commercial low molecular weight heparin. Heterofucans exhibited total antioxidant capacity, low hydroxyl radical scavenging activity, good superoxide radical scavenging efficiency (except CC-1.0), and excellent ferrous chelating ability (except CC-0.3). These results clearly indicate the beneficial effect of C. cervicornis polysaccharides as anticoagulants and antioxidants. Further purification steps and additional studies on structural features as well as in vivo experiments are needed to test the viability of their use as therapeutic agents	pt_BR
dc.identifier.citation	CAMARA, Rafael Barros Gomes da; COSTA, Leandro Silva; FIDELIS, Gabriel Pereira; NOBRE, Leonardo Thiago Duarte Barreto; DANTAS-SANTOS, Nednaldo; CORDEIRO, Sara Lima; COSTA, Mariana Santana Santos Pereira; ALVES, Luciana Guimaraes; ROCHA, Hugo Alexandre de Oliveira. Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities. Marine Drugs, [s. l.], v. 9, n. 1, p. 124-138, 24 jan. 2011. MDPI AG. http://dx.doi.org/10.3390/md9010124. Disponível em: https://www.mdpi.com/1660-3397/9/1/124. Acesso em: 16 set. 2020.	pt_BR
dc.identifier.doi	10.3390/md9010124
dc.identifier.issn	1660-3397 (online)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31326
dc.language	en	pt_BR
dc.publisher	MDPI	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Dictyota cervicornis	pt_BR
dc.subject	Fucoidan	pt_BR
dc.subject	Free radicals	pt_BR
dc.subject	Sulfated polysaccharides	pt_BR
dc.title	Heterofucans from the brown seaweed Canistrocarpus cervicornis with anticoagulant and antioxidant activities	pt_BR
dc.type	article	pt_BR