Place and grid cells in a loop: implications for memory function and spatial coding

Rennó-Costa, César; Tort, Adriano Bretanha Lopes

Place and grid cells in a loop: implications for memory function and spatial coding

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dc.contributor.author	Rennó-Costa, César
dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.date.accessioned	2017-07-31T12:11:07Z
dc.date.available	2017-07-31T12:11:07Z
dc.date.issued	2017-07-12
dc.description.resumo	Place cells in the hippocampus and grid cells in the medial entorhinal cortex have different codes for space. However, how one code relates to the other is ill understood. Based on the anatomy of the entorhinal-hippocampal circuitry, we constructed a model of place and grid cells organized in a loop to investigate their mutual influence in the establishment of their codes for space. Using computer simulations, we first replicated experiments in rats that measured place and grid cell activity in different environments, and then assessed which features of the model account for different phenomena observed in neurophysiological data, such as pattern completion and pattern separation, global and rate remapping of place cells and realignment of grid cells. We found that (1) the interaction between grid and place cells converges quickly; (2) the spatial code of place cells does not require - but is altered by - grid cell input; (3) plasticity in sensory inputs to place cells is key for pattern completion but not pattern separation; (4) grid realignment can be explained in terms of place cell remapping as opposed to the other way around; (5) the switch between global and rate remapping is self-organized; (6) grid cell input to place cells helps stabilize their code under noisy and/or inconsistent sensory input. We conclude that the hippocampus-entorhinal circuit uses the mutual interaction of place and grid cells to encode the surrounding environment and propose a theory on how such interdependence underlies the formation and use of the cognitive map.	pt_BR
dc.identifier.doi	https://doi.org/10.1523/JNEUROSCI.3490-16.2017
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23675
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	memory	pt_BR
dc.subject	spatial coding	pt_BR
dc.subject	hippocampus	pt_BR
dc.subject	entorhinal-hippocampal circuitry	pt_BR
dc.title	Place and grid cells in a loop: implications for memory function and spatial coding	pt_BR
dc.type	article	pt_BR