In vitro studies reveal antiurolithic effect of antioxidant sulfated polysaccharides from the green seaweed Caulerpa cupressoides var flabellata

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dc.contributor.authorGomes, Dayanne Lopes
dc.contributor.authorMelo, Karoline Rachel Teodosio
dc.contributor.authorQueiroz, Moacir Fernandes
dc.contributor.authorBatista, Lucas Alighieri Neves Costa
dc.contributor.authorSantos, Pablo Castro
dc.contributor.authorCosta, Mariana Santana Santos Pereira
dc.contributor.authorAlmeida-Lima, Jailma
dc.contributor.authorCâmara, Rafael Barros Gomes da
dc.contributor.authorCosta, Leandro Silva
dc.contributor.authorRocha, Hugo Alexandre de Oliveira
dc.date.accessioned2021-01-05T17:07:07Z
dc.date.available2021-01-05T17:07:07Z
dc.date.issued2019-06-01
dc.description.resumoUrolithiasis affects approximately 10% of the world population and is strongly associated with calcium oxalate (CaOx) crystals. Currently, there is no efficient compound that can be used to prevent this disease. However, seaweeds’ sulfated polysaccharides (SPs) can change the CaOx crystals surface’s charge and thus modify the crystallization dynamics, due to the interaction of the negative charges of these polymers with the crystal surface during their synthesis. We observed that the SPs of Caulerpa cupressoides modified the morphology, size and surface charge of CaOx crystals. Thus, these crystals became similar to those found in healthy persons. In the presence of SPs, dihydrate CaOx crystals showed rounded or dumbbell morphology. Infrared analysis, fluorescence microscopy, flow cytometry (FITC-conjugated SPs) and atomic composition analysis (EDS) allowed us to propose the mode of action between the Caulerpa’s SPs and the CaOx crystals. This study is the first step in understanding the interactions between SPs, which are promising molecules for the treatment of urolithiasis, and CaOx crystals, which are the main cause of kidney stonespt_BR
dc.identifier.citationGOMES, Dayanne Lopes; MELO, Karoline Rachel Teodosio; QUEIROZ, Moacir Fernandes; BATISTA, Lucas Alighieri Neves Costa; SANTOS, Pablo Castro; COSTA, Mariana Santana Santos Pereira; ALMEIDA-LIMA, Jailma; CAMARA, Rafael Barros Gomes da; COSTA, Leandro Silva; ROCHA, Hugo Alexandre de Oliveira. In vitro studies reveal antiurolithic effect of antioxidant sulfated polysaccharides from the green seaweed Caulerpa cupressoides var flabellata. Marine Drugs, [s. l.], v. 17, n. 6, p. 326-341, 1 jun. 2019. MDPI AG. Disponível em: https://www.mdpi.com/1660-3397/17/6/326. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/md17060326.pt_BR
dc.identifier.doi10.3390/md17060326
dc.identifier.issn1660-3397 (online)
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/31190
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectUrolithiasispt_BR
dc.subjectGreen algaept_BR
dc.subjectCOD dumbbellpt_BR
dc.subjectCOD stabilizationpt_BR
dc.titleIn vitro studies reveal antiurolithic effect of antioxidant sulfated polysaccharides from the green seaweed Caulerpa cupressoides var flabellatapt_BR
dc.typearticlept_BR

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