Engenharia tecidual óssea em reconstruções mandibulares: uma revisão sistemática de estudos in vitro

Abstract

Bone tissue engineering has emerged as a promising approach for treating mandibular defects, offering significant advancements over traditional techniques. This study aimed to systematically evaluate in vitro studies investigating the combination of stem cells, scaffolds, and growth factors applied to mandibular bone reconstruction. A search was conducted in the databases PubMed/Medline, Web of Science, Science Direct, Scopus, Embase, Lilacs and Opengrey. Out of 1958 publications, 23 studies met the inclusion criteria and were analyzed. The results indicated that bone marrow mesenchymal stem cells from humans (BMMSCs) and rats (r-BMMSCs) are among the most utilized. Regarding scaffolds, those made with porous hydroxyapatite and nano-hydroxyapatite stood out for their mechanical, biological, and structural properties, which were considered suitable for the studies. Innovative technologies, such as 3D printing and the development of specific biomaterials, have shown promise in promoting bone regeneration and integration. However, despite these advancements, the literature highlights the need for additional studies to validate these strategies in clinical settings.