A small interfering RNA (siRNA) database for SARS-CoV-2

Medeiros, Inácio Gomes; Khayat, André Salim; Stransky, Beatriz; Santos, Sidney; Assumpção, Paulo; Souza, Jorge Estefano Santana de

A small interfering RNA (siRNA) database for SARS-CoV-2

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dc.contributor.author	Medeiros, Inácio Gomes
dc.contributor.author	Khayat, André Salim
dc.contributor.author	Stransky, Beatriz
dc.contributor.author	Santos, Sidney
dc.contributor.author	Assumpção, Paulo
dc.contributor.author	Souza, Jorge Estefano Santana de
dc.date.accessioned	2021-04-26T14:45:42Z
dc.date.available	2021-04-26T14:45:42Z
dc.date.issued	2021-04-23
dc.description.resumo	Coronavirus disease 2019 (COVID-19) rapidly transformed into a global pandemic, for which a demand for developing antivirals capable of targeting the SARS-CoV-2 RNA genome and blocking the activity of its genes has emerged. In this work, we presented a database of SARS-CoV-2 targets for small interference RNA (siRNA) based approaches, aiming to speed the design process by providing a broad set of possible targets and siRNA sequences. The siRNAs sequences are characterized and evaluated by more than 170 features, including thermodynamic information, base context, target genes and alignment information of sequences against the human genome, and diverse SARS-CoV-2 strains, to assess possible bindings to off-target sequences. This dataset is available as a set of four tables, available in a spreadsheet and CSV (Comma-Separated Values) formats, each one corresponding to sequences of 18, 19, 20, and 21 nucleotides length, aiming to meet the diversity of technology and expertise among laboratories around the world. A metadata table (Supplementary Table S1), which describes each feature, is also provided in the aforementioned formats. We hope that this database helps to speed up the development of new target antivirals for SARS-CoV-2, contributing to a possible strategy for a faster and effective response to the COVID-19 pandemic	pt_BR
dc.identifier.citation	MEDEIROS, I. G.; KHAYAT, A. S.; STRANSKY, B.; SANTOS, S. et al. A small interfering RNA (siRNA) database for SARS-CoV-2. Sci Rep, [S. l.], v. 11, n. 1, p. 8849, abr. 2021. Disponível em: https://www.nature.com/articles/s41598-021-88310-8. Acesso em: 26 abr. 2021.	pt_BR
dc.identifier.doi	10.1038/s41598-021-88310-8
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/32318
dc.language	en	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	SARS-CoV-2 - Database	pt_BR
dc.subject	Small interference RNA	pt_BR
dc.subject	Antiviral Agents	pt_BR
dc.title	A small interfering RNA (siRNA) database for SARS-CoV-2	pt_BR
dc.type	article	pt_BR