Análise da forma fosforilada do fator de choque térmico 1 (pHSF 1) em carcinomas de células escamosas de língua oral

Abstract

The squamous cell carcinoma (SCC) of the oral tongue presents morbimortality high levels although recent achievements of malignancies treatment. This way, a lot of researches are trying to detect morphological alterations or identify biomarkers that may present recurrence prediction power and metastasis and new strategies and/or more individualized therapeutic options in order to improve the prognosis of these patients. The Heat shock factor 1 (HSF1) acts in different ways of tumoral progressing, facilitating the appearance, development and tumoral invasiveness and its overexpression has been researched in malignancies. This research had the aim to analize if the phosphorylated form of Heat shock factor 1 (p-HSF1) carries some influence in the SCC of the oral tongue pathogenesis. There was an immunohistochemical study in 69 cases of oral tongue squamous cell carcinoma observing the p-HSF1 expression and correlating this immunoexpression with some clinicopathological parameters and patients’ survival. It was evaluated and compared the immunohistochemical score of the p-HSF1 between the squamous cell carcinoma (SCC) of the oral tongue and normal oral mucosa (MON) and this expression was correlated to the histological gradation systems proposed by Brandwein-Gensler et al. (2005) and by the model BD (ALMANGUSH et al., 2014). Survival analysis of association curves with the other parameters were carried out with the Kaplan Meier method and the differences of these curves submitted to the test log-rank (p<0,05). It was found a bigger immunoexpression score (p<0,001) of p-HSF1 in squamous cell carcinoma (SCC) of the oral tongue in relation to the MON, suggesting this factor may influence the tumors pathogenesis.. The tumor size ( T ) T3/ T4 was associated to the high risk not only by system of Brandwein-Gensler et al. (2005) as by model BD (ALMANGUSH et al., 2014), suggesting bigger tumors may be associated to worse histopathological parameters. The analysis result through the BD method, showed prognostic implication, since as patients classified as high risk by this system were associated to a smaller global survival and bigger death number, suggesting its possible inclusion as a useful tool in the prognosis determination of patients with squamous cell carcinoma (SCC) of the oral tongue.