Acurácia da autoamostragem de HPV em comparação com outras ferramentas de rastreio cervical – um protocolo de revisão sistemática

Abstract

Introduction Cervical cancer is among the most common types of cancer in women and currently screening for the disease is done through Pap smears, a method that detects pre-cancerous lesions caused by the human papillomavirus (HPV). Selfcollection strategies are increasingly being studied and evaluated regarding the possibility of being alternative or complementary methods to cervical examination, presenting sensitivity and specificity comparable to the traditional method, and characterizing as promising screening tests for the early diagnosis of cervical cancer. This study aims is to evaluate and compare the accuracy between HPV self-collection and other cervical screening tools. Methods and analysis A search will be carried out on the PubMed, Embase, Scopus, Web of Science, and LILACS data platforms. No language restrictions or publication period will be defined, and the results will be evaluated and selected by two independente authors, as well as data extraction and risk assessment, a tool by QUADAS-2. We will include cross-sectional studies that evaluate the accuracy (sensitivity and specificity) of self-collection and compared it, with a study population of women aged between 25 and 65 years old tested with self-sampling. For data analysis, we will use 'R' software with the "meta" and "mada" packages. Ethics and dissemination Formal ethical approval is not required as no primary data are collected. This systematic review will be disseminated through a peer-reviewed publication.