Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment

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dc.contributor.authorLeitão, Luciana Pereira Colares
dc.contributor.authorMonte, Natasha
dc.contributor.authorRodrigues, Juliana Carla Gomes
dc.contributor.authorFreitas, Lilian Marques de
dc.contributor.authorSantos, André Mauricio Ribeiro dos
dc.contributor.authorSantos, Andrea Kely Campos Ribeiro dos
dc.contributor.authorSantos, Sidney
dc.contributor.authorSouza, Sandro José de
dc.contributor.authorFernandes, Marianne Rodrigues
dc.contributor.authorSantos, Ney Pereira Carneiro dos
dc.date.accessioned2025-01-08T12:54:04Z
dc.date.available2025-01-08T12:54:04Z
dc.date.issued2024-11
dc.description.resumoCorticosteroids, such as prednisone or dexamethasone, constitute integral components of antineoplastic regimens for Acute Lymphoblastic Leukemia (ALL) therapy, albeit accompanied by significant adverse effects. The multifactorial nature of interindividual variability in drug response, encompassing genetic polymorphisms, underscores the complexity of pharmacotherapy outcomes. However, pharmacogenetic investigations hitherto have predominantly focused on cohorts of European and North American descent, thus limiting the generalizability of findings to populations with minimal representation. Indigenous populations in Brazil, particularly those inhabiting the Amazon region, exhibit a distinctive genetic heritage, predominantly characterized by Native American ancestry. These populations frequently manifest suboptimal therapeutic responses and elevated mortality rates following ALL treatment. Therefore, delineating the molecular signatures of genes implicated in the corticosteroid pathway within these indigenous cohorts assumes paramount importance. This study identified novel variants within genes associated with the glucocorticoid pathway in indigenous Amazonian populations and conducted comparative analyses of variant frequencies across diverse global populations. The findings underscore the genetic uniqueness of indigenous groups and highlight the potential impact of genetic factors on adverse responses to ALL treatment. Precision medicine approaches tailored to the genetic peculiarities of indigenous populations emerge as imperative strategies for optimizing therapeutic efficacy and mitigating treatment-related toxicities in these communitiespt_BR
dc.identifier.citationLEITÃO, Luciana Pereira Colares; MONTE, Natasha; RODRIGUES, Juliana Carla Gomes; FREITAS, Lilian Marques de; RIBEIRO-DOS-SANTOS, André Maurício; RIBEIRO-DOS-SANTOS, Ândrea; SANTOS, Sidney; SOUZA, Sandro José de; FERNANDES, Marianne Rodrigues; SANTOS, Ney Pereira Carneiro dos. Severe toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatment. Scientific Reports, [S. l.], v. 14, n. 1, p. 29344, nov. 2024. Doi: http://dx.doi.org/10.1038/s41598-024-80393-3. Disponível em: https://www.nature.com/articles/s41598-024-80393-3. Acesso em: 07 jan. 2025pt_BR
dc.identifier.doi10.1038/s41598-024-80393-3
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/61047
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectAcute Lymphoblastic Leukemia - Indigenous populationspt_BR
dc.subjectPrecision medicine - Indigenous populationspt_BR
dc.titleSevere toxicities in amazonian populations and the role of precision medicine in acute lymphoblastic leukemia treatmentpt_BR
dc.typearticlept_BR

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