Editorial: On the destabilization of maladaptive memory: updates and future perspectives
| dc.contributor.author | Radiske, Andressa | |
| dc.contributor.author | Cahill, Emma N. | |
| dc.contributor.author | Milton, Amy L. | |
| dc.contributor.author | Cammarota, Martín Pablo | |
| dc.date.accessioned | 2024-02-19T14:28:32Z | |
| dc.date.available | 2024-02-19T14:28:32Z | |
| dc.date.issued | 2024-01 | |
| dc.description.resumo | Intense fear induces persistent memories that can result in exacerbated maladaptive avoidance and lead to the development of phobias and other anxiety disorders. Similarly, drug addiction has been related to the formation of strong pervasive memories that trigger craving and relapse. Long-lasting consolidated memories can become destabilized when reactivated and, to endure, must undergo a protein synthesis-dependent restabilization in a process called reconsolidation (Nader et al., 2000). Because inhibition of memory restabilization appears to cause amnesia in laboratory animals, it has been suggested that therapies based on the pharmacological or behavioral modulation of this process may be useful to treat anxiety or addiction-related disorders (Monfils and Holmes, 2018). Although our knowledge about the molecular basis of memory reconsolidation has grown exponentially during the last two decades, there is no widespread reconsolidation therapy yet, and large-scale clinical trials are yet to be conducted. Furthermore, it is usually impractical and sometimes unethical, to reenact the behavioral and emotional conditions required for successful memory destabilization during psychotherapy, and the boundary conditions for ‘real life' memories (as opposed to those generated by experimental procedures) are not fully understood. To overcome this limitation, it has been argued that basic research should focus on elucidating the molecular and physiological signatures of reactivation-induced memory destabilization to determine specific reconsolidation biomarkers (Radiske et al., 2020; Milton et al., 2023). In this Research Topic, we have compiled original research articles presenting the latest findings on the mechanisms underlying memory destabilization | pt_BR |
| dc.identifier.citation | RADISKE, Andressa; CAHILL, Emma N.; MILTON, Amy L.; CAMMAROTA, Martín. Editorial: on the destabilization of maladaptive memory. Frontiers In Behavioral Neuroscience, [S. l.], v. 17, p. 1351704, jan. 2024. Doi: http://dx.doi.org/10.3389/fnbeh.2023.1351704. Disponível em: https://www.frontiersin.org/articles/10.3389/fnbeh.2023.1351704/full. Acesso em: 19 fev. 2024 | pt_BR |
| dc.identifier.doi | 10.3389/fnbeh.2023.1351704 | |
| dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/57642 | |
| dc.language | en | pt_BR |
| dc.publisher | Frontiers Media SA | pt_BR |
| dc.rights | Attribution 3.0 Brazil | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/br/ | * |
| dc.subject | Maladaptive memory | pt_BR |
| dc.subject | Memory destabilization | pt_BR |
| dc.subject | Memory reconsolidation | pt_BR |
| dc.title | Editorial: On the destabilization of maladaptive memory: updates and future perspectives | pt_BR |
| dc.type | article | pt_BR |
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