The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome

Santos, Ana Celly Souza dos; Soares, Nayara Pereira; Costa, Eduardo Caldas; Sá, Joceline Cássia Ferrezini de; Azevedo, George Dantas de; Lemos, Telma Maria Araújo Moura

The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome

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dc.contributor.author	Santos, Ana Celly Souza dos
dc.contributor.author	Soares, Nayara Pereira
dc.contributor.author	Costa, Eduardo Caldas
dc.contributor.author	Sá, Joceline Cássia Ferrezini de
dc.contributor.author	Azevedo, George Dantas de
dc.contributor.author	Lemos, Telma Maria Araújo Moura
dc.date.accessioned	2021-02-23T18:35:18Z
dc.date.available	2021-02-23T18:35:18Z
dc.date.issued	2015-11-06
dc.description.resumo	Objective: to evaluate inflammatory markers and insulin resistance (IR) in women with and without polycystic ovary syndrome (PCOS), with different body mass index (BMI). Methods: tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6) and C-reactive protein (CRP) were assessed in serum samples from 40 women in reproductive age. Patients were divided into four groups: I (non-eutrophic with PCOS, n¼12), II (non-eutrophic without PCOS, n¼10), III (eutrophic with PCOS, n¼8) and IV (eutrophic without PCOS, n¼10) being non-eutrophic, the overweight and obese women with BMI425 kg/m2 and eutrophic women with BMI524.9 kg/m2. Homeostatic model assessment (HOMA-IR) was calculated for evaluation of IR. Results: PCOS patients showed increased levels of CRP (p50.01) and HOMA-IR (p50.01). When divided by BMI, both non-eutrophic and eutrophic PCOS showed increased CRP levels (p50.01) and HOMA-IR (p50.01). There were no differences in TNF-a and IL-6 levels between groups. Conclusion: in the PCOS group, the levels of CRP and IR were elevated, compared to their counterparts, regardless of body mass	pt_BR
dc.identifier.citation	SANTOS, Ana Celly Souza dos; SOARES, Nayara Pereira; COSTA, Eduardo Caldas; SÁ, Joceline Cássia Ferrezini de; AZEVEDO, George Dantas de; LEMOS, Telma Maria Araújo Moura. The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome. Gynecological Endocrinology, [s. l.], v. 31, n. 3, p. 225-228, 6 nov. 2015. Disponível em: https://www.tandfonline.com/doi/abs/10.3109/09513590.2014.976546?journalCode=igye20. Acesso em: 02 jul. 2020. http://dx.doi.org/10.3109/09513590.2014.976546	pt_BR
dc.identifier.doi	10.3109/09513590.2014.976546
dc.identifier.issn	0951-3590
dc.identifier.issn	1473-0766
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31611
dc.language	en	pt_BR
dc.publisher	Taylor and Francis	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Cytokines	pt_BR
dc.subject	Inflammation	pt_BR
dc.subject	Insulin resistance	pt_BR
dc.subject	Nutritional status	pt_BR
dc.subject	Obesity	pt_BR
dc.subject	Ovary	pt_BR
dc.subject	Polycystic ovary syndrome	pt_BR
dc.title	The impact of body mass on inflammatory markers and insulin resistance in polycystic ovary syndrome	pt_BR
dc.type	article	pt_BR