In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape

Página do item simplificado Estatísticas
dc.contributor.authorLuppi, Andrea I.
dc.contributor.authorHansen, Justine Y.
dc.contributor.authorAdapa, Ram
dc.contributor.authorCarhart-Harris, Robin L.
dc.contributor.authorRoseman, Leor
dc.contributor.authorTimmermann, Christopher
dc.contributor.authorGolkowski, Daniel
dc.contributor.authorRanft, Andreas
dc.contributor.authorIlg, Rüdiger
dc.contributor.authorJordan, Denis
dc.contributor.authorBonhomme, Vincent
dc.contributor.authorVanhaudenhuyse, Audrey
dc.contributor.authorDemertzi, Athena
dc.contributor.authorJaquet, Oceane
dc.contributor.authorBahri, Mohamed Ali
dc.contributor.authorAlnagger, Naji L. N.
dc.contributor.authorCardone, Paolo
dc.contributor.authorPeattie, Alexander R. D.
dc.contributor.authorManktelow, Anne E.
dc.contributor.authorAraujo, Draulio Barros de
dc.contributor.authorSensi, Stefano L.
dc.contributor.authorOwen, Adrian M.
dc.contributor.authorNaci, Lorina
dc.contributor.authorMenon, David K.
dc.contributor.authorMisic, Bratislav
dc.contributor.authorStamatakis, Emmanuel A.
dc.date.accessioned2023-07-26T12:13:24Z
dc.date.available2023-07-26T12:13:24Z
dc.date.issued2023-06
dc.description.resumoTo understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain’s rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters obtained from positron emission tomography, and the regional changes in functional magnetic resonance imaging connectivity induced by 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, and methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs’ effects on brain function and multiple neurotransmitter systems. The effects of both anesthetics and psychedelics on brain function are organized along hierarchical gradients of brain structure and function. Last, we show that regional co-susceptibility to pharmacological interventions recapitulates co-susceptibility to disorder-induced structural alterations. Collectively, these results highlight rich statistical patterns relating molecular chemoarchitecture and drug-induced reorganization of the brain’s functional architecturept_BR
dc.identifier.citationLUPPI, Andrea I.; HANSEN, Justine Y.; ADAPA, Ram; CARHART-HARRIS, Robin L.; ROSEMAN, Leor; TIMMERMANN, Christopher; GOLKOWSKI, Daniel; RANFT, Andreas; ILG, Rüdiger; JORDAN, Denis et al. In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape. Science Advances, [S. l.], v. 9, n. 24, p. eadf8332, jun. 2023. Doi: http://dx.doi.org/10.1126/sciadv.adf8332. Disponível em: https://www.science.org/doi/10.1126/sciadv.adf8332. Acesso em: 25 jul. 2023.pt_BR
dc.identifier.doi10.1126/sciadv.adf8332
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54175
dc.languageenpt_BR
dc.publisherAmerican Association for the Advancement of Science (AAAS)pt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectNeurotransmitter landscape - Human brainpt_BR
dc.subjectPsychoactive drugs - Brain functionpt_BR
dc.subjectMolecular chemoarchitecturept_BR
dc.subjectBrain’s functional architecturept_BR
dc.titleIn vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscapept_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
VivoMappingofPharmacologically_Araujo_2023.pdf
Tamanho:
2.01 MB
Formato:
Adobe Portable Document Format
Descrição:
VivoMappingofPharmacologically_Araujo_2023
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM