Zika virus infection histories in brain development

Página do item simplificado Estatísticas
dc.contributor.authorMarcelino, Bruna Lorena de Melo
dc.contributor.authorSantos, Brendha Leandro dos
dc.contributor.authorDoerl, Jhulimar Guilherme
dc.contributor.authorCavalcante, Samantha de Freitas
dc.contributor.authorMaia, Sara do Nascimento
dc.contributor.authorArrais, Nivia Maria Rodrigues
dc.contributor.authorZin, Andrea Araujo
dc.contributor.authorJeronimo, Selma Maria Bezerra
dc.contributor.authorQueiroz, Claudio Marcos Teixeira de
dc.contributor.authorPereira, Cecilia Hedin
dc.contributor.authorSequerra, Eduardo Bouth
dc.date.accessioned2023-10-11T17:30:32Z
dc.date.available2023-10-11T17:30:32Z
dc.date.issued2023-07
dc.description.resumoAn outbreak of births of microcephalic patients in Brazil motivated multiple studies on this incident. The data left no doubt that infection by Zika virus (ZIKV) was the cause, and that this virus promotes reduction in neuron numbers and neuronal death. Analysis of patients' characteristics revealed additional aspects of the pathology alongside the decrease in neuronal number. Here, we review the data from human, molecular, cell and animal model studies attempting to build the natural history of ZIKV in the embryonic central nervous system (CNS). We discuss how identifying the timing of infection and the pathways through which ZIKV may infect and spread through the CNS can help explain the diversity of phenotypes found in congenital ZIKV syndrome (CZVS). We suggest that intraneuronal viral transport is the primary mechanism of ZIKV spread in the embryonic brain and is responsible for most cases of CZVS. According to this hypothesis, the viral transport through the blood-brain barrier and cerebrospinal fluid is responsible for more severe pathologies in which ZIKV-induced malformations occur along the entire anteroposterior CNS axispt_BR
dc.identifier.citationMARCELINO, Bruna L. M.; SANTOS, Brendha L. dos; DOERL, Jhulimar G.; CAVALCANTE, Samantha F.; MAIA, Sara N.; ARRAIS, Nivia M. R.; ZIN, Andrea; JERONIMO, Selma M. B.; QUEIROZ, Claudio; HEDIN-PEREIRA, Cecilia; SEQUERRA, Eduardo B. Zika virus infection histories in brain development. Disease Models & Mechanisms, [S. l.], v. 16, n. 7, p. dmm050005, jul. 2023. Doi: http://dx.doi.org/10.1242/dmm.050005. Disponível em: https://journals.biologists.com/dmm/article/16/7/dmm050005/323960/Zika-virus-infection-histories-in-brain. Acesso em: 11 out. 2023pt_BR
dc.identifier.doi10.1242/dmm.050005
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54972
dc.languageenpt_BR
dc.publisherThe Company of Biologistspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectZika virus infectionpt_BR
dc.subjectBlood–brain barrierpt_BR
dc.subjectBrainstempt_BR
dc.subjectCalcificationpt_BR
dc.subjectCerebellumpt_BR
dc.subjectNeuronal migrationpt_BR
dc.subjectSusceptibility windowpt_BR
dc.titleZika virus infection histories in brain developmentpt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
ZikaVirusInfection_Sequerra_2023.pdf
Tamanho:
1.75 MB
Formato:
Adobe Portable Document Format
Descrição:
ZikaVirusInfection_Sequerra_2023
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM