Orientation selectivity of neurons and their spatial layout in cat and agouti primary visual cortex

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dc.contributor.advisorSchmidt, Kerstin Erika
dc.contributor.advisorIDpt_BR
dc.contributor.authorFerreiro, Dardo Nahuel
dc.contributor.authorIDpt_BR
dc.contributor.referees1Queiroz, Cláudio Marcos Teixeira de
dc.contributor.referees1IDpt_BR
dc.contributor.referees2Diniz, Cristovam Wanderley Picanço
dc.contributor.referees2IDpt_BR
dc.contributor.referees3Leão, Emelie Katarina Svahn
dc.contributor.referees3IDpt_BR
dc.contributor.referees4Baron, Jerome Paul Armand Laurent
dc.contributor.referees4IDpt_BR
dc.date.accessioned2018-05-22T20:40:59Z
dc.date.available2018-05-22T20:40:59Z
dc.date.issued2018-03-27
dc.description.resumoSo far, there is no evidence of columnar orientation preference maps in rodent primary visual cortex, such as commonly observed in carnivores and primates. Nevertheless, orientation selective neurons have been found in all rodent species investigated, though interspersed. This opens up the question whether the connectivity underlying the emergence of selective cortical response properties in animals with interspersed as compared to columnar maps follows a different blueprint. Rodent data are so far mainly available for species with nocturnal or crepuscular habits and small brain size, two factors that could also contribute to develop a different functional architecture. Therefore, we set out to compare the functional architecture of the primary visual cortex of carnivores with that of a big rodent with diurnal habits, and a V1 size comparable to cats and small primates. We performed multi-site electrophysiological recordings using spatial arrays from both anesthetized cats’ (Felis catus) and agoutis’ (Dasyprocta aguti) visual cortex. Visual stimuli consisted of contrast reversing checkerboards and oriented gratings of several spatial and temporal frequencies. Agoutis presented smaller orientation selectivity indices (median OSI = 0.10) than cats (median OSI = 0.19), and lower proportions of orientation (~45% for agouti V1 and ~75% for cat A18) and direction (~35% for agouti V1 and ~65% for cat A18) selective neurons. In order to describe the functional architecture based on the electrophysiological data, we quantified the orientation preference similarity between neurons according to the cortical distance between them. This analysis revealed a characteristic slow decrease in neuronal orientation preference similarity for cats. No such “classical” modularity was found for agoutis, but a clustering of neurons with similar orientation preference was observed for short ranges (< 250 μm). Overall, our results are consistent with recent literature reporting ‘mini-columns’ of orientation preference in mice, and therefore further prove that the rodents’ interspersed maps are not random, as previously assumed. We refute, however, recent theoretical literature suggesting that agoutis might have “classical” columnar orientation preference maps. Future research should focus on understanding the circuits, which lead to small selective receptive fields in agoutis and great visual performance while adopting a different functional architecture.pt_BR
dc.identifier.citationFERREIRO, Dardo Nahuel. Orientation selectivity of neurons and their spatial layout in cat and agouti primary visual cortex. 2018. 67f. Tese (Doutorado em Neurociências) - Universidade Federal do Rio Grande do Norte, Universidade Federal do Rio Grande do Norte, Natal, 2018.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25247
dc.languageporpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFRNpt_BR
dc.publisher.programPROGRAMA DE PÓS-GRADUAÇÃO EM NEUROCIÊNCIASpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectCórtex visualpt_BR
dc.subjectCutiapt_BR
dc.subjectAgoutipt_BR
dc.subjectGatopt_BR
dc.subjectEletrofisiologiapt_BR
dc.subjectAnatomia funcionalpt_BR
dc.subjectMapa de orientaçãopt_BR
dc.subject.cnpqCNPQ::OUTROS::CIENCIAS: NEUROCIÊNCIASpt_BR
dc.titleOrientation selectivity of neurons and their spatial layout in cat and agouti primary visual cortexpt_BR
dc.typedoctoralThesispt_BR

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