Plasma zinc in institutionalized elderly individuals: relation with immune and cardiometabolic biomarkers

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dc.contributor.authorLyra, Clélia de Oliveira
dc.contributor.authorSales, Márcia Cristina
dc.contributor.authorOliveira, Larissa Praça de
dc.contributor.authorCabral, Natalia Louise de Araújo
dc.contributor.authorSousa, Sara Estéfani Soares de
dc.contributor.authorAlmeida, Maria das Graças
dc.contributor.authorLemos, Telma Maria Araújo Moura
dc.contributor.authorLima, Kenio Costa de
dc.contributor.authorEvangelista, Karine Cavalcanti Mauricio Sena
dc.contributor.authorPedrosa, Lucia de Fatima Campos
dc.date.accessioned2024-03-26T22:21:18Z
dc.date.available2024-03-26T22:21:18Z
dc.date.issued2018-12
dc.description.resumoChanges in zinc metabolism caused by aging and the institutionalization process may contribute to zinc deficiency in elderly individuals. Hypozincemia results in changes in glycemic, lipid, and inflammatory profiles. The aim of this study was to evaluate plasma zinc concentrations and their relationships with sociodemographic, dietary, inflammatory, and cardiometabolic biomarkers in institutionalized elderly individuals. A cross-sectional study was carried out including 255 elderly adults living in nursing homes. The associations between plasma zinc and dietary zinc intake, sociodemographic indicators, and glycemic, lipid, and inflammatory biomarkers were evaluated. Independent variables were analyzed according to quartiles of plasma zinc concentrations (Q1: <71.1 μg/dL; Q2: 71.1–83.3 μg/dL; Q3: <83.3–93.7 μg/dL; Q4: >93.7 μg/dL). The relationship between plasma zinc concentrations and predictor variables was also tested. In Q1, higher concentrations of the following variables were observed, compared with those in other quartiles: total cholesterol and low-density lipoprotein cholesterol (LDL-c; Q1 > Q2, Q3, Q4; all p <0.001); triglycerides (Q1 > Q3, Q4; all p < 0.001); interleukin (IL)-6 (Q1 > Q3, Q4; p = 0.024 and p = 0.010, respectively); tumor necrosis factor (TNF)-α (Q1 > Q3, p = 0.003). A significant reduction in plasma zinc concentrations was observed with increasing age-adjusted institutionalization time (Δ = − 0.10; 95% confidence interval [CI]: −0.18 to −0.01). The concentrations of total cholesterol (Δ = − 0.19; 95% CI: −0.23 to −0.15), LDL-c (Δ = − 0.19; 95% CI: −0.23 to −0.15), triglycerides (Δ = − 0.11; 95% CI: −0.16 to −0.06), IL-6 (Δ = − 1.41; 95% CI: −2.64 to −0.18), and TNF-α (Δ = − 1.04; 95% CI: −1.71 to −0.36) were also significantly increased. In conclusion, decreased plasma zinc concentrations were associated with longer institutionalization time and worse lipid and inflammatory profiles in elderly institutionalized individualspt_BR
dc.identifier.citationSALES, Márcia Cristina; OLIVEIRA, Larissa Praça de; CABRAL, Natalia Louise de Araújo; SOUSA, Sara Estéfani Soares de; ALMEIDA, Maria das Graças; LEMOS, Telma Maria Araújo Moura; LYRA, Clélia de Oliveira; LIMA, Kenio Costa de; EVANGELISTA, Karine Cavalcanti Mauricio Sena; PEDROSA, Lucia de Fatima Campos. Plasma zinc in institutionalized elderly individuals: relation with immune and cardiometabolic biomarkers. Journal of Trace Elements In Medicine and Biology, [S.l.], v. 50, p. 615-621, dez. 2018. DOI: 10.1016/j.jtemb.2018.04.026. Disponível em: https://www.sciencedirect.com/science/article/pii/S0946672X17309203?via%3Dihub. Acesso em: 14 mar. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1016/j.jtemb.2018.04.026
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57953
dc.languageenpt_BR
dc.publisherJournal of Trace Elements in Medicine and Biologypt_BR
dc.subjectPlasma zincpt_BR
dc.subjectAgingpt_BR
dc.subjectNursing homept_BR
dc.subjectCytokinespt_BR
dc.subjectLipid profilept_BR
dc.titlePlasma zinc in institutionalized elderly individuals: relation with immune and cardiometabolic biomarkerspt_BR
dc.typearticlept_BR

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