NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling

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dc.contributor.authorFernandez-Berrocal, Marion S.
dc.contributor.authorReis, Amilcar
dc.contributor.authorRolseth, Veslemøy
dc.contributor.authorSuganthan, Rajikala
dc.contributor.authorKuśnierczyk, Anna
dc.contributor.authorFrança, Arthur
dc.contributor.authorSoares, Annara Yve Moura
dc.contributor.authorKunath, Nicolas
dc.contributor.authorBugaj, Anna M.
dc.contributor.authorAbentung, Andreas
dc.contributor.authorEide, Lars
dc.contributor.authorLeao, Richardson Naves
dc.contributor.authorBjørås, Magnar
dc.contributor.authorScheffler, Katja
dc.contributor.authorYe, Jing
dc.date.accessioned2025-03-17T14:07:38Z
dc.date.available2025-03-17T14:07:38Z
dc.date.issued2025-03
dc.description.resumoAdult neurogenesis in the hippocampus, involving the generation and integration of new neurons, is essential for behavioral pattern separation, which supports accurate memory recall and cognitive plasticity. Here, we explore the role of the DNA repair protein NEIL3 in adult hippocampal neurogenesis and behavioral pattern separation. NEIL3 is required for efficient proliferation and neuronal differentiation of neonatal NSPCs and adult-born NPCs in the hippocampus following a behavioral pattern separation task. NEIL3-depleted mice exhibited a reduced preference for the novel object location, indicating a deficit in pattern separation. NEIL3-deficient adult-born neurons exhibited a significant reduction in mature-like membrane properties, indicating impaired functional maturation. Interestingly, these impairments were not associated with the decreased genomic integrity but with the altered transcriptional regulation of the Wnt signaling pathway. Given the importance of adult neurogenesis in cognitive function, targeting NEIL3 could offer therapeutic potential for addressing age-related hippocampal dysfunction and cognitive declinept_BR
dc.identifier.citationFERNANDEZ-BERROCAL, Marion S.; REIS, Amilcar; ROLSETH, Veslemøy; SUGANTHAN, Rajikala; KUŚNIERCZYK, Anna; FRANÇA, Arthur; SOARES, Annara Y. M.; KUNATH, Nicolas; BUGAJ, Anna M.; ABENTUNG, Andreas; EIDE, Lars; LEAO, Richardson N.; BJØRÅS, Magnar; SCHEFFLER, Katja; YE, Jing. NEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signaling. Cellular And Molecular Life Sciences, [S. l.], v. 82, n. 1, p. 101, mar. 2025. Doi: http://dx.doi.org/10.1007/s00018-025-05629-5. Disponível em: https://link.springer.com/article/10.1007/s00018-025-05629-5. Acesso em: 17 mar. 2025pt_BR
dc.identifier.doi10.1007/s00018-025-05629-5
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/63021
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectHippocampal transcriptomept_BR
dc.subjectNEIL3 DNA glycosylasept_BR
dc.subjectNeural stem and progenitor cells (NSPCs)pt_BR
dc.subjectNovel object location (NOL)pt_BR
dc.subjectOxidative DNA damagept_BR
dc.subjectPatch-clamp recordingpt_BR
dc.titleNEIL3 influences adult neurogenesis and behavioral pattern separation via WNT signalingpt_BR
dc.typearticlept_BR

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