Levetiracetam reduced the basal excitability of the dentate gyrus without restoring impaired synaptic plasticity in rats with temporal lobe epilepsy

González-H, Guillermo; Contreras-García, Itzel Jatziri; Sánchez-Huerta, Karla; Queiroz, Claudio Marcos Teixeira de; Gallardo Gudiño, Luis Ricardo; Mendoza-Torreblanca, Julieta G; Zamudio, Sergio R

Levetiracetam reduced the basal excitability of the dentate gyrus without restoring impaired synaptic plasticity in rats with temporal lobe epilepsy

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dc.contributor.author	González-H, Guillermo
dc.contributor.author	Contreras-García, Itzel Jatziri
dc.contributor.author	Sánchez-Huerta, Karla
dc.contributor.author	Queiroz, Claudio Marcos Teixeira de
dc.contributor.author	Gallardo Gudiño, Luis Ricardo
dc.contributor.author	Mendoza-Torreblanca, Julieta G
dc.contributor.author	Zamudio, Sergio R
dc.date.accessioned	2020-09-23T17:38:57Z
dc.date.available	2020-09-23T17:38:57Z
dc.date.issued	2020-09
dc.description.resumo	Temporal lobe epilepsy (TLE), the most common type of focal epilepsy, affects learning and memory; these effects are thought to emerge from changes in synaptic plasticity. Levetiracetam (LEV) is a widely used antiepileptic drug that is also associated with the reversal of cognitive dysfunction. The long-lasting effect of LEV treatment and its participation in synaptic plasticity have not been explored in early chronic epilepsy. Therefore, through the measurement of evoked field potentials, this study aimed to comprehensively identify the alterations in the excitability and the short-term (depression/facilitation) and long-term synaptic plasticity (long-term potentiation, LTP) of the dentate gyrus of the hippocampus in a lithium-pilocarpine rat model of TLE, as well as their possible restoration by LEV (1 week; 300 mg/kg/day). TLE increased the population spike (PS) amplitude (input/output curve); interestingly, LEV treatment partially reduced this hyperexcitability. Furthermore, TLE augmented synaptic depression, suppressed paired-pulse facilitation, and reduced PS-LTP; however, LEV did not alleviate such alterations. Conversely, the excitatory postsynaptic potential (EPSP)-LTP of TLE rats was comparable to that of control rats and was decreased by LEV. LEV caused a long-lasting attenuation of basal hyperexcitability but did not restore impaired synaptic plasticity in the early chronic phase of TLE	pt_BR
dc.identifier.citation	GONZÁLEZ-H, G.; CONTRERAS-GARCÍA I. J.; SÁNCHEZ-HUERTA, K.; QUEIROZ, C. M. T.; GALLARDO GUDIÑO, L. R.; MENDOZA-TORREBLANCA, J. G.; ZAMUDIO, S. R. Levetiracetam reduced the basal excitability of the dentate gyrus without restoring impaired synaptic plasticity in rats with temporal lobe epilepsy. Brain Sci., [S. l.], v. 10, n. 9, p. E634, set. 2020. Doi: 10.3390/brainsci10090634. Disponível em: https://www.mdpi.com/2076-3425/10/9/634. Acesso em: 23 set. 2020.	pt_BR
dc.identifier.doi	10.3390/brainsci10090634
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/30183
dc.language	en	pt_BR
dc.publisher	MDPI	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Evoked field potentials	pt_BR
dc.subject	Inhibitory transmission	pt_BR
dc.subject	Levetiracetam	pt_BR
dc.subject	Synaptic plasticity	pt_BR
dc.subject	Temporal lobe epilepsy	pt_BR
dc.title	Levetiracetam reduced the basal excitability of the dentate gyrus without restoring impaired synaptic plasticity in rats with temporal lobe epilepsy	pt_BR
dc.type	article	pt_BR