Relação de células cd57+ com parâmetros clínico-patológicos em uma série de casos de carcinoma de células escamosas orais

Abstract

Background: One of the effective immune mechanisms against tumors is executed by cytotoxic cells (CD57+), which are naturally capable of destroying tumor cells. The aim of this study was to investigate the relationship between the clinicopathological parameters and immunoexpression of CD57+ inflammatory cells in patients with oral squamous cell carcinoma (OSCC). Methods: Paraffin-embedded sections of the 45 cases of OSCC were immunohistochemically treated by anti-CD57. Clinical data, as tumor-node-metastasis (TNM), node metastasis, habits were collected from medical records. Hematoxylin and eosin-stained sections were analyzed by histological grade of malignancy as system proposed by Bryne (1998). The quantitative analysis of CD57+ cells was related to with clinic pathologic parameters by Mann-Whitney test at significance level of p<0.05. Results: Among the patients, 64.4% were males with mean of age 53.36 years-old. Most of the cases occurred in the tongue (91.1%). Eleven patients were tabagist and etilist. The majority of patients (37.8%) were diagnosed as TNM stage III and 62.2% of the cases were classified with high-grade of malignancy. There was significant association between node metastasis and clinical stage with histologic grade (p<0.05). The majority of cases in stage I and II were gradated as lower grade (62.5%) and all cases with metastasis were classified was high-grade of malignancy. There was no association between CD57+ cells and clinical and morphological parameters (P>0.05). However, the immunostaining for CD57 was higher in T1 and T2 tumors without nodal metastasis. Conclusions: Our results show that CD57+ cells were more present in OSCC with early clinical stage and low grade of malignancy but without significant association. The possible relation of citotoxyc cells with clinical pathologic parameters in OSCC may be more investigated.