OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons

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dc.contributor.authorLeão, Richardson Naves
dc.contributor.authorMikulovic, Sanja
dc.contributor.authorLeão, Emelie Katarina Svahn
dc.contributor.authorMunguba, Hermany
dc.contributor.authorGezelius, Henrik
dc.contributor.authorEnjin, Anders
dc.contributor.authorPatra, Kalicharan
dc.contributor.authorEriksson, Anders
dc.contributor.authorLoew, Leslie M
dc.contributor.authorTort, Adriano Bretanha Lopes
dc.contributor.authorKullander, Klas
dc.date.accessioned2017-05-31T12:40:18Z
dc.date.available2017-05-31T12:40:18Z
dc.date.issued2012-11
dc.description.resumoThe vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval. However, dissection of the functional roles of defined interneuron types has been hampered by the lack of cell-specific tools. We identified a precise molecular marker for a population of hippocampal GABAergic interneurons known as oriens lacunosum-moleculare (OLM) cells. By combining transgenic mice and optogenetic tools, we found that OLM cells are important for gating the information flow in CA1, facilitating the transmission of intrahippocampal information (from CA3) while reducing the influence of extrahippocampal inputs (from the entorhinal cortex). Furthermore, we found that OLM cells were interconnected by gap junctions, received direct cholinergic inputs from subcortical afferents and accounted for the effect of nicotine on synaptic plasticity of the Schaffer collateral pathway. Our results suggest that acetylcholine acting through OLM cells can control the mnemonic processes executed by the hippocampus.pt_BR
dc.identifier.issn1097-6256
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23264
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectGABAergic interneuronspt_BR
dc.subjectCA1 neuronspt_BR
dc.subjectOLM interneuronspt_BR
dc.titleOLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neuronspt_BR
dc.typearticlept_BR

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