Antecedent infections in Guillain-Barré syndrome in endemic areas of arbovirus transmission: a multinational case-control study

dc.contributor.authorDourado Junior, Mário Emílio Teixeira
dc.contributor.authorLeonhard, Sonja E.
dc.contributor.authorTan, heng Yin
dc.contributor.authorLeonhard, Sonja E
dc.contributor.authorTan, Cheng Yin
dc.contributor.authorEijk, Annemiek A.
dc.contributor.authorReisin, Ricardo R.
dc.contributor.authorFranken, Suzanne C.
dc.contributor.authorHuizinga, Ruth
dc.contributor.authorArends, Samuel
dc.contributor.authorBatstra, Manou R.
dc.contributor.authorJeronimo, Selma M. Bezerra
dc.contributor.authorDrenthen, Judith
dc.contributor.authorIDhttps://orcid.org/0000-0002-9462-2294pt_BR
dc.date.accessioned2023-07-26T18:03:07Z
dc.date.available2023-07-26T18:03:07Z
dc.date.issued2021
dc.description.resumoHalf of the world's population is at risk of arthropod-borne virus (arbovirus) infec-tions. Several arbovirus infections have been associated with Guillain-Barré syn-drome (GBS). We investigated whether arboviruses are driving GBS beyond epidemicphases of transmission and studied the antibody response to glycolipids. The proto-col of the International Guillain-Barré syndrome Outcome Study (IGOS), an observa-tional prospective cohort study, was adapted to a case-control design. Serumsamples were tested for a recent infection with Zika virus (ZIKV), dengue virus(DENV), chikungunya (CHIKV) virus, hepatitis E virus, Epstein-Barr virus (EBV), cyto-megalovirus (CMV),Campylobacter jejuni, andMycoplasma pneumoniae, and for anti-bodies to glycolipids. Forty-nine patients were included from Brazil (63%), Argentina(14%), and Malaysia (22%). Evidence of a recent infection was found in 27/49 (55%)patients:C jejuni(n=15, 31%),M pneumoniae(n=5, 10%), CHIKV (n=2, 4%), EBV(n=1, 2%),C jejuniandM pneumoniae(n=2, 4%), CMV and DENV (n=1, 2%), andC jejuniand DENV (n=1, 2%). In 22 patients, 35 paired controls were collected.Odds ratio for recent infections did not significantly differ between cases and con-trols. No typical anti-ganglioside antibody binding was associated with recent arbovi-rus infection. We conclude that arbovirus infections occur in GBS patients outside ofepidemic viral transmission, although not significantly more than in controls. Broadinfection and anti-ganglioside antibody serology are important to establish the mostlikely pathogenic trigger in GBS patients. Larger studies are necessary to determinethe association between arboviruses and GBS.pt_BR
dc.identifier.citationLEONHARD, Sonja E.; TAN, Cheng Yin; EIJK, Annemiek A.; REISIN, Ricardo R.; FRANKEN, Suzanne C.; HUIZINGA, Ruth; ARENDS, Samuel; BATSTRA, Manou R.; JERONIMO, Selma M. Bezerra; DRENTHEN, Judith. Antecedent infections in Guillain‐Barré syndrome in endemic areas of arbovirus transmission: a multinational case⠰control study. Journal Of The Peripheral Nervous System, [S.L.], v. 26, n. 4, p. 449-460, 30 set. 2021. Wiley. http://dx.doi.org/10.1111/jns.12469. Disponível em: https://onlinelibrary.wiley.com/doi/10.1111/jns.12469. Acesso em: 14 jul. 2023.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1111/jns.12469
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54205
dc.languageenpt_BR
dc.publisherWileypt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectanti-ganglioside antibodiespt_BR
dc.subjectanti-glycolipid antibodiespt_BR
dc.subjectchikungunya viruspt_BR
dc.subjectdengue viruspt_BR
dc.subjectguillain-barré syndromept_BR
dc.subjectzika viruspt_BR
dc.titleAntecedent infections in Guillain-Barré syndrome in endemic areas of arbovirus transmission: a multinational case-control studypt_BR
dc.typearticlept_BR

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