Chromosome 17 abnormalities and mutation of the TP53 gene: Correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemia

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dc.contributor.authorOtero, Luize
dc.contributor.authorCavalcanti Júnior, Geraldo Barroso
dc.contributor.authorKlumb, Claudete Esteves
dc.contributor.authorScheiner, Marcos Antonio Mauricio
dc.contributor.authorMagluta, Eliane Pereira Simões
dc.contributor.authorFernandez, Teresa de Souza
dc.contributor.authorSilva, Maria Luiza Macedo
dc.contributor.authorPires, Virgínia
dc.contributor.authorAndrade, Gabriela Vasconcelos
dc.contributor.authorMaia, Raquel Ciuvalschi
dc.contributor.authorTabak, Daniel
dc.date.accessioned2021-09-30T19:15:36Z
dc.date.available2021-09-30T19:15:36Z
dc.date.issued2005
dc.description.resumoAlterations involving the short arm of chromosome 17 (17p) during the progression of chronic myeloid leukemia (CML) have been described. This chromosomal region contains the tumor suppressor gene TP53 that may be an important factor in the evolution of this disease. In this study, we used flow cytometry and western blotting to assess p53 protein expression and single stranded conformational polymorphism to examine TP53 gene alterations in three patients with CML who showed alterations in 17p. Only the case with del(17)(p11) had p53 expression positive by flow cytometry and an abnormal migration pattern by SSCP analysis. The importance of the correlation between the results obtained with these techniques, as well as the clinical course of the patients, are discussed.pt_BR
dc.identifier.citationOTERO, Luize; CAVALCANTI JÚNIOR, Geraldo Barroso; KLUMB, Claudete Esteves; SCHEINER, Marcos Antonio Mauricio; MAGLUTA, Eliane Pereira Simões; FERNANDEZ, Teresa de Souza; SILVA, Maria Luiza Macedo; PIRES, Virgínia; ANDRADE, Gabriela Vasconcelos; MAIA, Raquel Ciuvalschi; TABAK, Daniel. Chromosome 17 abnormalities and mutation of the TP53 gene: Correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemia. Genetics and Molecular Biology, p. 40-43, 2005. Disponível em: https://www.scielo.br/j/gmb/i/2005.v28n1/ Acesso em:30 set. 2021.pt_BR
dc.identifier.issn1415-4757
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/40854
dc.languagept_BRpt_BR
dc.publisherSociedade Brasileira de Genéticapt_BR
dc.subjectChronic myeloid leukemiapt_BR
dc.subjectChromosome 17pt_BR
dc.subjectTP53 genept_BR
dc.subjectP53 proteinpt_BR
dc.titleChromosome 17 abnormalities and mutation of the TP53 gene: Correlation between cytogenetics, flow cytometry and molecular analysis in three cases of chronic myeloid leukemiapt_BR
dc.typearticlept_BR

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