Telmisartan decreases inflammation by modulating TNF-a, IL-10, and RANK/RANKL in a rat model of ulcerative colitis

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dc.contributor.authorSilva, Késia Karina de Oliveira Souto
dc.contributor.authorGuerra, Gerlane Coelho Bernardo
dc.contributor.authorAraujo, Aurigena Antunes de
dc.contributor.authorLira, George A.
dc.contributor.authorMelo, Maryanne N.
dc.contributor.authorFernandes, Daline
dc.contributor.authorSilva, Arthur L.
dc.contributor.authorAraujo Junior, Raimundo Fernandes de
dc.date.accessioned2022-02-22T19:34:27Z
dc.date.available2022-02-22T19:34:27Z
dc.date.issued2015-06
dc.description.resumoBackground: Telmisartan is an antihypertensive angiotensin II receptor blocker. This antihypertensive shows antiinflammatory activity. Purpose: In this study, the antiinflammatory activity of telmisartan was tested in an acetic acid (10%) model of ulcerative colitis (UC) in rats. Methods: Rats were given 1, 3, and 5 mg/kg/day of telmisartan orally for 3 days before induction of UC. The same doses were also administered 2 and 24 h after induction. Rats from the non-colitis and non- treated colitis groups were administered vehicle (saline, 5 ml/kg) orally and another group received sulfasalazine (50 mg/kg/day). Colons tissue was analyzed by macroscopic, by histopathology, by the immunohistochemical examination of RANKL/RANK pathway; by ELISA analysis of the levels of IL-10, TNF-a, myeloperoxidase (MPO) and malonaldehyde (MDA). Results: Telmisartan at 5 mg/kg reduced levels of MPO, MDA, TNF-a and increased of IL-10 (p < 0.05). Additionally, telmisartan reduced macroscopic damage, number of ulcers, and inflammatory and histopathological processes such as neutrophil infiltration, changes in cytoarchitecture, and necrosis. Immunohistochemistry revealed down-regulation of nuclear factor-kappaB receptor/nuclear factor- kappaB ligand (RANK/RANKL) in groups treated with sulfasalazine or telmisartan. Conclusion: Telmisartan exerts beneficial effects in an acetic acid model of colitis in rats. These effects may be due to accelerated termination of the acute inflammatory phase, indicated by decreased TNF-a and increased production of IL-10 and low expression of RANKL and RANK. 2014 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp.pt_BR
dc.identifier.citationGUERRA, Gerlane C. B.; ARAÚJO, Aurigena A.; LIRA, George A.; MELO, Maryanne N.; SOUTO, Késia K. O.; FERNANDES, Daline; SILVA, Arthur L.; ARAÚJO JÚNIOR, Raimundo F.. Telmisartan decreases inflammation by modulating TNF-α, IL-10, and RANK/RANKL in a rat model of ulcerative colitis. Pharmacological Reports, [S. l.], v. 67, n. 3, p. 520-526, jun. 2015. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1016/j.pharep.2014.12.011. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S173411401400382X?via%3Dihub. Acesso em: 11 abr. 2021.pt_BR
dc.identifier.doiorg/10.1016/j.pharep.2014.12.011
dc.identifier.issnElectronic: 1734-1140
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/46194
dc.languageenpt_BR
dc.publisherPharmacological Reportspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectangiotensin II receptor blockerspt_BR
dc.subjectantiinflammatorypt_BR
dc.subjectimmunohistochemicalpt_BR
dc.subjectratspt_BR
dc.titleTelmisartan decreases inflammation by modulating TNF-a, IL-10, and RANK/RANKL in a rat model of ulcerative colitispt_BR
dc.typearticlept_BR

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