DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity

Santos, Marcelo dos; Maia, L. L.; Silva, C. V. M.; Peterle, G. T.; Mercante, A. M. C.; Nunes, F. D.; Carvalho, M. B.; Tajara, E. H.; Louro, I. D.; Silva-Conforti, A. M. A.

DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity

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dc.contributor.author	Santos, Marcelo dos
dc.contributor.author	Maia, L. L.
dc.contributor.author	Silva, C. V. M.
dc.contributor.author	Peterle, G. T.
dc.contributor.author	Mercante, A. M. C.
dc.contributor.author	Nunes, F. D.
dc.contributor.author	Carvalho, M. B.
dc.contributor.author	Tajara, E. H.
dc.contributor.author	Louro, I. D.
dc.contributor.author	Silva-Conforti, A. M. A.
dc.date.accessioned	2021-02-09T17:36:55Z
dc.date.available	2021-02-09T17:36:55Z
dc.date.issued	2015-09-08
dc.description.resumo	Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively regulates autophagy, which has been associated with the development and progression of several diseases, such as cancer, and with prognosis and survival of diverse tumor types. Therefore, in this study we analyzed DAP1 expression in 54 oral squamous cell carcinoma tumor samples and in 20 non-tumoral margins by immunohistochemistry. The results showed that DAP1 is more frequently expressed in tumor tissues compared with marginal non-tumoral cells. Additionally, high DAP1 expression is associated with a 4-fold increase in the risk of lymph node metastases. Our results suggest that the DAP1 protein can be used as a potential marker of lymph node metastases predisposition, helping define the best therapy for each patient to minimize risk of developing metastases	pt_BR
dc.identifier.citation	SANTOS, Marcelo dos; MAIA, L. L.; SILVA, C. V. M.; PETERLE, G. T.; MERCANTE, A. M. C.; NUNES, F. D.; CARVALHO, M. B.; TAJARA, E. H.; LOURO, I. D.; SILVA-CONFORTI, A. M. A. DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity. Genetics and Molecular Research, [s. l.], v. 14, n. 3, p. 10515-10523, 2015. Disponível em: http://www.gencapo.famerp.br/pdf/santosm_2015.pdf. Acesso em: 07 jul. 2020. http://dx.doi.org/10.4238/2015.September.8.13	pt_BR
dc.identifier.doi	10.4238/2015.September.8.13
dc.identifier.issn	1676-5680 (print)
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31436
dc.language	en	pt_BR
dc.publisher	Fundação de Pesquisas de Ribeirão Preto	pt_BR
dc.rights	Attribution-NonCommercial-ShareAlike 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-sa/3.0/br/	*
dc.subject	DAP1 expression	pt_BR
dc.subject	Lymph node	pt_BR
dc.subject	Prognostic marker	pt_BR
dc.subject	Oral cancer	pt_BR
dc.title	DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity	pt_BR
dc.type	article	pt_BR