A geographical study on amyotrophic lateral sclerosis in Rio Grande Do Norte, Brazil, from 2005 to 2018

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dc.contributor.authorGonçalves, Maria De Jesus
dc.contributor.authorOliveira, Roberto Teodoro Gurgel De
dc.contributor.authorSantana, Glauciane Costa
dc.contributor.authorFregonezi, Guilherme Augusto De Freitas
dc.contributor.authorVale, Sancha Helena De Lima
dc.contributor.authorLais, Lucia Leite
dc.contributor.authorIDhttps://orcid.org/0000-0003-2580-485Xpt_BR
dc.date.accessioned2023-06-21T23:02:26Z
dc.date.available2023-06-21T23:02:26Z
dc.date.issued2022
dc.description.resumoObjective: amyotrophic lateral sclerosis (ALS) is a rare and fatal neurodegenerative disorder with variable incidence and prevalence worldwide. However, clinical-epidemiological studies on ALS are scarce in Brazil. Thus, this study investigated whether ALS incidence had uniform spatial distribution in population-based cluster analysis in Rio Grande do Norte state (Brazil), from 2005 to 2018. Methods: new cases of ALS were identified in a database of the ALS multidisciplinary care center of the Onofre Lopes University Hospital in Natal (Rio Grande do Norte, Brazil). Approaches were based on incidence (empirical Bayes estimator and Moran's I analysis) and cluster analyses (Moran scatter plot and spatial correlogram). Results: a total of 177 patients (59% males) participated in the study; the mean age of ALS onset was 57 years. Mean annual incidence of ALS was 0.3769 per 100,000 inhabitants (95% confidence interval of 0.0889), higher in males than in females (0.4516 per 100,000 vs. 0.3044 per 100,000). According to spatial statistics, patients were homogeneously distributed throughout the studied area. Conclusion: a low estimate was observed compared with other populations. Results did not indicate areas of increased risk or significant spatial geographic dependence, suggesting a random ALS incidence in Rio Grande do Norte.pt_BR
dc.identifier.citationOLIVEIRA, Roberto Teodoro Gurgel de; SANTANA, Glauciane Costa; GONÇALVES, Maria de Jesus; FREGONEZI, Guilherme Augusto de Freitas; VALE, Sancha Helena de Lima; LEITE-LAIS, Lucia; DOURADO, Mário Emílio Teixeira. A geographical study on amyotrophic lateral sclerosis in Rio Grande Do Norte, Brazil, from 2005 to 2018. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration, [S.L.], v. 24, n. 1-2, p. 117-124, 2 ago. 2022. Informa UK Limited. http://dx.doi.org/10.1080/21678421.2022.2102429. Disponível em: https://www.tandfonline.com/doi/full/10.1080/21678421.2022.2102429. Acesso em: 19 jun. 2023.pt_BR
dc.identifier.doihttps://doi.org/10.1080/21678421.2022.2102429
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/52837
dc.languageenpt_BR
dc.publisherTaylor and Francis Grouppt_BR
dc.subjectamyotrophic lateral sclerosispt_BR
dc.subjectmotor neuron diseasept_BR
dc.subjectepidemiologypt_BR
dc.subjectincidencept_BR
dc.subjectspatial analysispt_BR
dc.titleA geographical study on amyotrophic lateral sclerosis in Rio Grande Do Norte, Brazil, from 2005 to 2018pt_BR
dc.typearticlept_BR

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