Nicotine modulates the long-lasting storage of fear memory

dc.contributor.author	Lima, Ramón H.
dc.contributor.author	Radiske, Andressa
dc.contributor.author	Köhler, Cristiano A.
dc.contributor.author	Gonzalez, Maria Carolina
dc.contributor.author	Bevilaqua, Lia Rejane Müller
dc.contributor.author	Rossato, Janine I.
dc.contributor.author	Medina, Jorge H.
dc.contributor.author	Cammarota, Martín Pablo
dc.date.accessioned	2017-06-01T12:57:37Z
dc.date.available	2017-06-01T12:57:37Z
dc.date.issued	2013
dc.description.resumo	Late post-training activation of the ventral tegmental area (VTA)–hippocampus dopaminergic loop controls the entry of information into long-term memory (LTM). Nicotinic acetylcholine receptors (nAChR) modulate VTA function, but their involvement in LTM storage is unknown. Using pharmacological and behavioral tools, we found that α7-nAChR-mediated cholinergic interactions between the pedunculopontine tegmental nucleus and the medial prefrontal cortex modulate the duration of fear-motivated memories, maybe by regulating the activation state of VTA–hippocampus dopamine connections.	pt_BR
dc.identifier.doi	10.1101/lm.029900.112
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23337
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	hippocampus	pt_BR
dc.subject	ventral tegmental area	pt_BR
dc.subject	long-term memory	pt_BR
dc.subject	Nicotinic acetylcholine receptors	pt_BR
dc.title	Nicotine modulates the long-lasting storage of fear memory	pt_BR
dc.type	article	pt_BR