Analysis of the immunohistochemical expression of ghrelin in the gastric mucosa and correlation with weight loss after sleeve gastrectomy

Página do item simplificado Estatísticas
dc.contributor.authorQuinino, Reynaldo Martins e
dc.contributor.authorBarbosa, André Luis Costa
dc.contributor.authorXavier, Maíra de Araújo Barros
dc.contributor.authorFrança, Romero de Lima
dc.contributor.authorFreitas, Mirella Patrícia Cruz de
dc.contributor.authorGoldenberg, Alberto
dc.contributor.authorIDhttps://orcid.org/0000-0002-4284-2543pt_BR
dc.date.accessioned2023-07-10T19:32:12Z
dc.date.available2023-07-10T19:32:12Z
dc.date.issued2022-09-23
dc.description.resumoIntroduction Sleeve gastrectomy is one of the main techniques used to treat severe obesity. The study of the immunohistochemical expression of ghrelin in the gastric mucosa has already been related to weight loss and can be a promising method to predict the surgical outcome. Purpose To analyze the immunohistochemical expression of ghrelin in the gastric mucosa and its correlation with weight loss, comorbidities, and infammatory changes after sleeve gastrectomy. Methods Thirty-fve patients submitted to sleeve gastrectomy were evaluated, 29 of whom were female (82.9%), with a mean age of 35.2 years and an average body mass index of 38.1 kg/m2 . Endoscopic samples of the mucosa were collected, whose ghrelin expression was evaluated in a semi-quantitative way through the stained antibody area. These data were correlated with weight loss at 3, 6, and 12 months and with the control of comorbidities, and infammatory alterations. Results The average total weight loss (TWL%) was 17.7, 26.4, and 32.1%, respectively, at 3, 6, and 12 months. A negative correlation was found between the immunohistochemical expression of ghrelin in the endoscopic biopsy of the fundus and weight loss at 3 (s= −0.536; p=0.001) and 6 months (s= −0.339; p=0.047). Conclusion The immunohistochemical expression of ghrelin in the mucosa of the gastric fundus was negatively correlated with early weight loss after sleeve gastrectomypt_BR
dc.identifier.citationQUININO, Reynaldo Martins e; BARBOSA, André Luis Costa; XAVIER, Maíra de Araújo Barros; FRANÇA, Romero de Lima; FREITAS, Mirella Patrícia Cruz de; GOLDENBERG, Alberto. Analysis of the Immunohistochemical Expression of Ghrelin in the Gastric Mucosa and Correlation with Weight Loss After Sleeve Gastrectomy. Obesity Surgery, [S.L.], v. 32, n. 11, p. 3687-3695, 23 set. 2022. Springer Science and Business Media LLC. http://dx.doi.org/10.1007/s11695-022-06286-4. Disponível em: https://link.springer.com/article/10.1007/s11695-022-06286-4. Acesso em: 10 jul. 2023.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1007/s11695-022-06286-4
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/53197
dc.languageenpt_BR
dc.publisherSpringerpt_BR
dc.subjectbariatric surgerypt_BR
dc.subjectghrelinpt_BR
dc.subjectimmunochemistrypt_BR
dc.titleAnalysis of the immunohistochemical expression of ghrelin in the gastric mucosa and correlation with weight loss after sleeve gastrectomypt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
AnalysisImmunohistochemical_Quinino_Etal_2022.pdf
Tamanho:
1.3 MB
Formato:
Adobe Portable Document Format
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

CCS - DMI - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM