A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where

Tort, Adriano Bretanha Lopes; Komorowski, Robert; Kopell, Nancy; Eichenbaum, Howard

A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where

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dc.contributor.author	Tort, Adriano Bretanha Lopes
dc.contributor.author	Komorowski, Robert
dc.contributor.author	Kopell, Nancy
dc.contributor.author	Eichenbaum, Howard
dc.date.accessioned	2017-05-26T14:01:17Z
dc.date.available	2017-05-26T14:01:17Z
dc.date.issued	2011
dc.description.resumo	The association of specific events with the context in which they occur is a fundamental feature of episodic memory. However, the underlying network mechanisms generating what–where associations are poorly understood. Recently we reported that some hippocampal principal neurons develop representations of specific events occurring in particular locations (item-position cells). Here, we investigate the emergence of item-position selectivity as rats learn new associations for reward and find that before the animal’s performance rises above chance in the task, neurons that will later become itemposition cells have a strong selective bias toward one of two behavioral responses, which the animal will subsequently make to that stimulus. This response bias results in an asymmetry of neural activity on correct and error trials that could drive the emergence of particular item specificities based on a simple reward-driven synaptic plasticity mechanism.	pt_BR
dc.identifier.issn	1549-5485
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23115
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Hippocampal neuronal firing	pt_BR
dc.subject	Episodic memory	pt_BR
dc.subject	Synaptic plasticity mechanism	pt_BR
dc.title	A mechanism for the formation of hippocampal neuronal firing patterns that represent what happens where	pt_BR
dc.type	article	pt_BR