Perfil inflamatório das parasitoses intestinais causadas por helmintos: uma revisão

Abstract

Helminths infect billions of people worldwide, when transmitted to the host cause aggression through spoiling, toxic, mechanical or ectopic localization, hence an immune response and inflammation. Thus, this review addresses the immunological and immunoregulator mechanisms of these parasites in order to better understand how the pathogens are applied by helminths. For all intestinal helminths, a similar inflammatory profile was found: the innate response, followed by activation of the alternative complement pathway, which stimulates C3b (opsonization) and C5a (activates mast cells, basophils and inflammation), as well as the adaptive response (Th2), where parts of the parasite, the associated molecular patterns Pathogens (PAMP), are recognized by antigen presenting cells (APC) and via Class II Main Histocompatibility Complex (MHC II) pathway, it is presented for TCD4, also called Th0, turns Th0 into Th2, so Th2 now produces various substances like IL-13, IL-4, IL-5. All the mechanisms discussed in this review contributed to a better understanding of the pathogenesis developed, as well as to guide new research.