Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption

Radiske, Andressa; Gonzalez, Maria Carolina; Ocazionez, Sergio Andrés Conde; Rossato, Janine Inez; Köhler, Cristiano André; Cammarota, Martín Pablo

Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption

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dc.contributor.author	Radiske, Andressa
dc.contributor.author	Gonzalez, Maria Carolina
dc.contributor.author	Ocazionez, Sergio Andrés Conde
dc.contributor.author	Rossato, Janine Inez
dc.contributor.author	Köhler, Cristiano André
dc.contributor.author	Cammarota, Martín Pablo
dc.date.accessioned	2020-07-24T13:01:19Z
dc.date.available	2020-07-24T13:01:19Z
dc.date.issued	2020-07-13
dc.description.resumo	Avoidance memory reactivation at recall triggers hippocampal theta-gamma phase amplitude coupling (hPAC) only when it elicits hippocampus-dependent reconsolidation. However, it is not known whether there is a causal relationship between these phenomena. We found that in adult male Wistar rats, silencing the medial septum during recall did not affect avoidance memory expression or maintenance but abolished hPAC and the amnesia caused by the intra-hippocampal administration of reconsolidation blockers, both of which were restored by concomitant theta burst stimulation of the fimbria-fornix pathway. Remarkably, artificial hPAC generated by fimbria-fornix stimulation during recall of a learned avoidance response naturally resistant to hippocampus-dependent reconsolidation made it susceptible to reactivation-dependent amnesia. Our results indicate that hPAC mediates the destabilization required for avoidance memory reconsolidation, and suggest that generation of artificial hPAC at recall overcomes the boundary conditions of this process.	pt_BR
dc.identifier.citation	RADISKE, Andressa; GONZALEZ, Maria Carolina; CONDE-OCAZIONEZ, Sergio; ROSSATO, Janine I.; KÖHLER, Cristiano A.; CAMMAROTA, Martín. Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption. The Journal of Neuroscience, [S.l.], jul. 2020. http://dx.doi.org/10.1523/jneurosci.0259-20.2020. Disponível em: https://www.jneurosci.org/content/early/2020/07/13/JNEUROSCI.0259-20.2020. Acesso em: 24 jul. 2020.	pt_BR
dc.identifier.doi	10.1523/JNEUROSCI.0259-20.2020
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/29719
dc.language	en	pt_BR
dc.publisher	Society for Neuroscience	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Theta rhythm	pt_BR
dc.subject	Gamma rhythm	pt_BR
dc.subject	Stress disorders, post-traumatic	pt_BR
dc.subject	Amnesia	pt_BR
dc.subject	Memory consolidation	pt_BR
dc.title	Cross-frequency phase-amplitude coupling between hippocampal theta and gamma oscillations during recall destabilizes memory and renders it susceptible to reconsolidation disruption	pt_BR
dc.type	article	pt_BR