CB - DFIS - Artigos publicados em periódicos

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Aging-related changes on social synchronization of circadian activity rhythm in a diurnal primate (Callithrix jacchus)
(Taylor and Francis, 2020-06-23) Gonçalves, Fabiana Barbosa; Gonçalves, Bruno S. B.; Cavalcante, Jeferson de Souza; Azevedo, Carolina Virginia Macedo de
The input of environmental time cues and expression of circadian activity rhythms may change with aging. Among nonphotic zeitgebers, social cues from conspecific vocalizations may contribute to the stability and survival of individuals of social species, such as nonhuman primates. We evaluated aging- related changes on social synchronization of the circadian activity rhythm (CAR) in a social diurnal primate, the common marmoset. The activity of 18 male marmosets was recorded by actiwatches in two conditions. (1) Experimental – 4 young adult (5 ± 2 yrs of age) and 4 older (10 ± 2 yrs of age) animals maintained under LD 12/12 h and LL in a room with full insulation for light but only partial insulation for sound from vocalizations of conspecifics maintained outdoors in the colony; and (2) Control – 10 young adult animals maintained outdoors in the colony (5 animals as a control per age group). In LL, the CAR of young adults showed more stable synchronization with controls. Among the aged marmosets, two free-ran with τ > 24 h, whereas the other two showed relative coordination during the first 30 days in LL, but free-ran thereafter. These differences were reflected in the “social” phase angles (ψon and ψoff) between rhythms of experimental and control animal groups. Moreover, the activity patterns of aged animals showed lower social synchrony with controls compared to young adults, with the time lags of the time series between each experimental group and control group being negative in aged and positive in young adult animals (t-test, p < 0.05). The index of stability of the CAR showed no differences according to age, while the intradaily variability of the CAR was higher in the aged animals during LD-resynchronization, who took additional days to resynchronize. Thus, the social modulation on CAR may vary with age in marmosets. In the aged group, there was a lower effect of social synchronization, which may be associated with aging-related changes in the synchro- nization and generation of the CAR as well as in system outputs
Astragaloside IV supplementation promotes a neuroprotective effect in experimental models of neurological disorders: a systematic review
(Bentham Science Publishers, 2019-06-19) Costa, Ianara M.; Lima, Francisca O. V.; Fernandes, Luciana C. B.; Norrara, Bianca; I. Neta, Francisca; Alves, Rodrigo D.; Cavalcanti, José R. L. P.; Lucena, Eudes Euler de Souza; Cavalcante, Jeferson de Souza; Rego, Amalia C. M.; Araújo Filho, Irami; Queiroz, Dinalva B.; Freire, Marco A. M.; Guzen, Fausto P.
Background: Neurological disorders constitute a growing worldwide concern due to the progressive aging of the population and the risky behavior they represent. Herbal medicines have scientific relevance in the treatment of these pathologies. One of these substances, Astragaloside IV (AS-IV), is the main active compound present in the root of Astragalus membranaceus (Fisch.) Bge, a Chinese medicinal herb with neuroprotective properties. Objective: In the present study we performed a systematic review that sought to comprehend the neuroprotective effect presented by AS-IV in experimental models of neurological disorders. Methods: This study is a systematic review, where an electronic search in United States National Library of Medicine (PubMed), Science Direct, Cochrane Library, Scientific Electronic Library Online (SciELO), Scopus, Web of Science, Medline via Proquest and Periodicos Capes databases covering the years between 2007 and 2017, using “Astragaloside IV” and “Neurodegenerative diseases”; “Astragaloside IV” and “ Neurological disorders” as reference terms was made. Results: A total of 16 articles were identified, in which the efficacy of AS-IV was described in experimental models of Parkinson’s disease, Alzheimer’s disease, cerebral ischemia and autoimmune encephalomyelitis, by improving motor deficits and/or neurochemical activity, especially antioxidant systems, reducing inflammation and oxidative stress. Conclusion: The findings of the present study indicate that the administration of AS-IV can improve behavioral and neurochemical deficits largely due to its antioxidant, antiapoptotic and antiinflammatory properties, emerging as an alternative therapeutic approach for the treatment of neurological disorders
Avaliação da fidedignidade dos ensaios de esteróides fecais realizados no Laboratório de Medidas Hormonais do Departamento de Fisiologia da UFRN
(Publica, 2006) Nascimento, Heveline Gomes do; Fernandes, Luiz Carlos; Sousa, Maria Bernardete Cordeiro de
Caminos de la neurociencia en América Latina
(2013-01) Cardenas, Fernando P.; Araujo, John Fontenele; León, Laura Andrea
Não possui resumo.
Changes in peak expiratory flow and respiratory strength during the menstrual cycle
(Respiratory Physiology & Neurobiology, 2006) Silva, Selma Bruno da; Viana, Elizabel de Sousa Ramalho; Sousa, Maria Bernardete Cordeiro de
Chronotype ontogeny related to gender
(2014) Duarte, L.L; Menna-Barreto, L.; Miguel, M.A.L; Louzada, F.; Araújo, John Fontenele; Alam, M.; Areas, R.; Pedrazzoli, M.
Chronotype is an established concept designed to identify distinct phase relationships between the expression of circadian rhythms and external synchronizers in humans. Although it has been widely accepted that chronotype is subjected to ontogenetic modulation, there is no consensus on the interaction between age and gender. This study aimed to determine the relationship between age- and gender-related changes in the morningness-eveningness character in a large sample of people. A total of 14,650 volunteers were asked to complete the Brazilian version of the Horne and Östberg chronotype questionnaire. The data demonstrated that, on average, women were more morning-oriented than men until the age of 30 and there were no significant differences between men and women from 30 to 45 years of age. In contrast to the situation observed until the age of 30, women older than 45 years were more evening-oriented than men. These results suggest that the ontogenetic development of the circadian timekeeping system is more plastic in men, as represented by the larger amplitude of chronotype changes throughout their aging process. The phase delay of adolescence and phase advance of the elderly seem to be phenomena that are more markedly present in men than in women. Thus, our data, for the first time, provide support that sharply opposes the view that there is a single path toward morningness as a function of age, regardless of gender.
Circadian variation with a diurnal bimodal profile on scent-marking behavior in captive common marmosets (callitrhix jacchus)
(2006) Sousa, Maria Bernardete Cordeiro de; Moura, Silvana Lúcio Nogueira; Menezes, Alexandre Augusto de Lara
Combination sciatic nerve graft and fibroblastic growth factor 2 promotestissue regeneration for NF-200 and 5-HT in spinal cord injury
(Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2018-07) Fernandes, Aline Samaya Santos; Castro, Aline Brito Ferreira de; Rêgo, Amália Cinthia Meneses do; Araújo Filho, Irami; Lucena, Eudes Euler de Souza; Cavalcanti, José Rodolfo Lopes de Paiva; Costa, Ianara Mendonça da; Cavalcante, Jeferson de Souza; Costa, Mirian Stela Maris de Oliveira; Guzen, Fausto Pierdoná
Traumatic injury to the spinal cord results in a rapid and significant loss of function. One barrier to successful regeneration in the adult CNS is the diminished axonal growth capacity after maturation. Therefore, strategies that seek to promote the restoration of function to the chronically injured spinal cord have high therapeutic value. Neurotrophic factors and peripheral nerves are known to be good substrates for bridging the lesions associatedwith CNS trauma. The role of fibroblast growth factor-2, when added to the sciatic nerve, was examined following spinal cord injury in a rat. We evaluated whether FGF-2 added to a sciatic nerve graft placed in a gap promoted nerve recovery following a complete transection of the spinal cord and if it could enhance neuronal plasticity. Rats underwent a transection at the thoracic level, which was repaired with saline or a fragment of the sciatic nerve. In another group, FGF-2 was added immediately after thelesion. The effects of FGF-2 and the fragment of the sciatic nerve graft on neuronal plasticity were investigated at the epicenterof the injury using NF-200 and 5-HT immunoreactivity after 8 weeks.A high number of NF-200 and 5-HT immunoreactive fibers were observed in the treated groups with sciatic nerve graft in the presence or absence of FGF-2 when compared to the saline group. However, a small number of NF-200(p=0.03)and 5-HT fibers were observed in the epicenter of the graft when FGF-2 was added,when compared to the group that received sciatic nerve graft. These results indicate that sciatic nerve grafting favors the growth of fibers in the traumatized spinal cord, an effect that is slightly influenced by the addition of FGF-2 to the NF-200 and 5-HT immunoreactive fibers
Contested dominance modifies the anovulatory consequences of social subordination in female marmosets
(Braz J Med Biol Res, 2006) Alencar, A. I.; Sousa, Maria Bernardete Cordeiro de; Abbott, D.H.; Yamamoto, Maria Emília
Daily anticipatory rhythms of behavior and body temperature in response to glucose availability in rats
(2012) Carneiro, Breno T. S.; Fernandes, Diego A. C.; Medeiros, Caio F. P.; Diniz, Nathália L.; Araujo, John Fontenele
When food is available recurrently at a particular time of day, several species increase their locomotion in the hours that precede food delivery, a phenomenon called food anticipatory activity (FAA). In mammals, many studies have shown that FAA is driven by a food-entrained circadian oscillator (FEO) that is distinct from the light-entrained pacemaker in the suprachiasmatic nucleus of the hypothalamus. Few studies have investigated the effect of sugar ingestion on food anticipatory rhythms and the FEO. We aimed to extend the understanding of the role of glucose on the emergence of food anticipatory rhythms by investigating whether glucose ingestion is sufficient to produce daily food anticipation, reflected by motor activity and core body temperature rhythms. Under a 12 h/12 h light/dark cycle, chow-deprived rats had glucose solution available between Zeitgeber Time (ZT) 6 and ZT 9 for 10 days (glucose restriction group), whereas control animals had chow available within the same time window (chow restriction group). Animals in both groups exhibited anticipatory motor activity and body temperature around the fourth day of the scheduled food restriction. Glucose-fed rats ingested ~15 kcal on the days immediately before FAA emergence and reached an intake of ~20 kcal/day, whereas chow-fed rats ingested ~40 kcal/day. The glucose restriction group exhibited a pattern of food anticipation (activity and temperature) that was extremely similar to that observed in the chow restriction group. We conclude that glucose ingestion is a sufficient temporal cue to produce recurrent food anticipation, reflected by activity and temperature rhythms, in rats.
Development of new techniques for behavioral evaluation In animals submitted to facial nerve damage
(Research Journal of Pharmaceutical, Biological and Chemical Sciences, 2019) Oliveira, Lucidio Clebeson de; Oliveira, Eligleidson José Vidal de; Lucena, Eudes Euler de Souza; Cavalcanti, José Rodolfo Lopes de Paiva; Fernandes, João Paulo Costa; Souza Júnior, José Edvan de; Cavalcante, Jeferson de Souza; Azevedo, Eduardo Pereira de; Rêgo, Amália Cinthia Meneses do; Araújo Filho, Irami; Castro, Aline Brito Ferreira de; Guzen, Fausto Pierdoná
Three new methods for evaluating facial nerve injury were developed: Spontaneous ocular opening, vibrissae reflex and resistance to upper eyelid lifting. Nerve crush injury was performed by pressing the mice’s facial nerve with forceps for 30 seconds. Scores were given based on the comparison between the behavioral assessment of the injured and non-injured sides. Facial nerve injury is currently evaluated by observing the movement of the mice’s vibrissae and the ocular closure. In this study, three additional tests are proposed. Therefore, a wider evaluation can be accomplished where all the aspects of the facial mimicry can be assessed. The use of the 3 new methods described in this study, in addition to the 2 methods currently used, allows a complete behavioral assessment of facial nerve lesions as several behavioral aspects related to these injuries can be evaluated
Disruption of neocortical synchronisation during slow-wave sleep in the rotenone model of Parkinson’s disease
(Wiley, 2020-07-28) Lima, Gustavo Zampier dos Santos; Targa, Adriano D. S.; Cavalcante, Samantha de Freitas; Rodrigues, Lais S.; Araújo, John Fontenele; Torterolo, Pablo; Andersen, Monica L.; Lima, Marcelo M. S.
Parkinson’s disease motor dysfunctions are associated with improperly organised neural oscillatory activity. The presence of such disruption at the early stages of the disease in which altered sleep is one of the main features could be a relevant predictive feature. Based on this, we aimed to investigate the neocortical synchronisation dynamics during slow-wave sleep (SWS) in the rotenone model of Parkinson’s disease. After rotenone administration within the substantia nigra pars compacta, one group of male Wistar rats underwent sleep–wake recording. Considering the association between SWS oscillatory activity and memory consolidation, another group of rats underwent a memory test. The fine temporal structure of synchronisation dynamics was evaluated by a recently developed technique called first return map. We observed that rotenone administration decreased the time spent in SWS and altered the power spectrum within different frequency bands, whilst it increased the transition rate from a synchronised to desynchronised state. This neurotoxin also increased the probability of longer and decreased the probability of shorter desynchronisation events. At the same time, we observed impairment in object recognition memory. These findings depict an electrophysiological fingerprint represented by a disruption in the typical oscillatory activity within the neocortex at the early stages of Parkinson’s disease, concomitant with a decrease in the time spent in SWS and impairment in recognition memory
Dream characteristics in a Brazilian sample: an online survey focusing on lucid dreaming
(2013-12) Rolim, Sérgio A. Mota; Targino, Zé H.; Souza, Bryan C.; Blanco, Wilfredo; Araujo, John F.; Ribeiro, Sidarta
During sleep, humans experience the offline images and sensations that we call dreams, which are typically emotional and lacking in rational judgment of their bizarreness. However, during lucid dreaming (LD), subjects know that they are dreaming, and may control oneiric content. Dreaming and LD features have been studied in North Americans, Europeans and Asians, but not among Brazilians, the largest population in Latin America. Here we investigated dreams and LD characteristics in a Brazilian sample (n = 3,427; median age = 25 years) through an online survey. The subjects reported recalling dreams at least once a week (76%), and that dreams typically depicted actions (93%), known people (92%), sounds/voices (78%), and colored images (76%). The oneiric content was associated with plans for the upcoming days (37%), memories of the previous day (13%), or unrelated to the dreamer (30%). Nightmares usually depicted anxiety/fear (65%), being stalked (48%), or other unpleasant sensations (47%). These data corroborate Freudian notion of day residue in dreams, and suggest that dreams and nightmares are simulations of life situations that are related to our psychobiological integrity. Regarding LD, we observed that 77% of the subjects experienced LD at least once in life (44% up to 10 episodes ever), and for 48% LD subjectively lasted less than 1 min. LD frequency correlated weakly with dream recall frequency (r = 0.20, p < 0.01), and LD control was rare (29%). LD occurrence was facilitated when subjects did not need to wake up early (38%), a situation that increases rapid eye movement sleep (REMS) duration, or when subjects were under stress (30%), which increases REMS transitions into waking. These results indicate that LD is relatively ubiquitous but rare, unstable, difficult to control, and facilitated by increases in REMS duration and transitions to wake state. Together with LD incidence in USA, Europe and Asia, our data from Latin America strengthen the notion that LD is a general phenomenon of the human species.
Efeito do parceiro social sobre a resposta comportamental ao ambiente novo em sagüi comum (Callithrix jacchus)
(2007) Ribeiro, Raíssa Risoleta Cavalcante; Galvão-Coelho, Nicole Leite; Sousa, Maria Bernardete Cordeiro de
Efeitos agudos do exercício físico no tratamento da dependência química
(2017-04) Ferreira, Sionaldo Eduardo; Santos, Anny Kalinne de Melo dos; Okano, Alexandre Hideki; Gonçalves, Bruno da Silva Brandão; Araújo, John Fontenele
Foram avaliados os efeitos do exercício físico na capacidade de atenção, na memória, no desejo de usar drogas, na percepção de esforço e prazer e no estado de humor de 16 indivíduos em tratamento para dependência de drogas. Foram usados a escala de Brunel, o teste de cancelamento de números, o teste dos blocos de Corsi, a escala de Borg e escala de valência afetiva ao esforço físico nas situações controle, pré e pós‐realização de uma sessão de exercícios físicos (60 min). Foi observada redução no desejo de usar drogas e no tempo de execução do teste de cancelamento de números, e aumento no número de blocos recordados. Os resultados apontam a importância do profissional da educação física nas equipes para tratamento da dependência química.
Effect of FGF-2 and sciatic nerve grafting on ChAT expression in dorsal root ganglia neurons of spinal cord transected rats
(Elsevier, 2016-03) Guzen, Fausto Pierdoná; Araújo, Dayane Pessoa de; Lucena, Eudes Euler de Souza; Morais, Hécio Henrique Araújo de; Cavalcanti, José Rodolfo Lopes de Paiva; Nascimento Junior, Expedito Silva do; Costa, Miriam Stela Maris de Oliveira; Cavalcante, Jeferson de Souza
Neurotrophic factors and peripheral nerves are known to be good substrates for bridging CNS trauma. The involvement of fibroblast growth factor-2 (FGF-2) activation in the dorsal root ganglion (DRG) was examined following spinal cord injury in the rat. We evaluated whether FGF-2 increases the ability of a sciatic nerve graft to enhance neuronal plasticity, in a gap promoted by complete transection of the spinal cord. The rats were subjected to a 4 mm-long gap at low thoracic level and were repaired with saline (Saline or control group, n = 10), or fragment of the sciatic nerve (Nerve group, n = 10), or fragment of the sciatic nerve to which FGF-2 (Nerve + FGF-2 group, n = 10) had been added immediately after lesion. The effects of the FGF-2 and fragment of the sciatic nerve grafts on neuronal plasticity were investigated using choline acetyl transferase (ChAT)-immunoreactivity of neurons in the dorsal root ganglion after 8 weeks. Preservation of the area and diameter of neuronal cell bodies in dorsal root ganglion (DRG) was seen in animals treated with the sciatic nerve, an effect enhanced by the addition of FGF-2. Thus, the addition of exogenous FGF-2 to a sciatic nerve fragment grafted in a gap of the rat spinal cord submitted to complete transection was able to improve neuroprotection in the DRG. The results emphasized that the manipulation of the microenvironment in the wound might amplify the regenerative capacity of peripheral neurons
Effect of sildenafil in renal ischemia/reperfusion injury in rats
(2010) Medeiros, Paulo José de; Neto, Arthur Villarim; Lima, Francisco Pignataro; Azevedo, Ítalo Medeiros; Leão, Layra Ribeiro de Sousa; Medeiros, Aldo Cunha
Evidence for age-related changes in the circadian activity rhythm of the diurnal primate Callithrix jacchus: a case report
(Taylor and Francis, 2016-01-29) Gonçalves, Fabiana Barbosa; Borges, Galileu R.; Gonçalves, Bruno S. B.; Cavalcante, Jeferson de Souza; Menezes, Alexandre A. L.; Azevedo, Carolina Virginia Macedo de
Many cross-sectional studies have shown that circadian rhythms change with age, but such age-related modifications are gradual and may be insufficiently described by cross- sectional studies. In the present case study, circadian activity rhythm (CAR) was evaluated longitudinally, in both LD (12:12) and LL conditions, on two occasions in a single male marmoset: when “adult” (3 y.o.) and when “old” (9 y.o.). When adult, the CAR synchronized with positive phase angles for the onset and offset of activity. In LL, the rhythm free-ran with τ < 24 h. When old, the animal showed a significant phase delay of its activity rhythm with respect to the LD cycle (t-test, p<0.01) and a reduction on total daily activity (t-test, p<0.01), with signs of lesser stability, greater fragmentation and some loss of photic synchronization. In LL, the period free-ran with τ > 24 h. We conclude that aging attenuates photic synchronization and the expression of a circadian activity rhythm in LL in the marmoset. Further studies with a larger number of individuals are needed to confirm these findings
Expansion and phenotypic changes of mouse bone marrow mesenchymal cells cultured with FGF-2 and facial nerve-conditioned medium
(Sociedade Chilena de Anatomía, 2018-09) Lucena, Eudes Euler de Souza; Morais, Hécio Henrique Araújo de; Araújo, Dayane Pessoa de; Cavalcanti, José Rodolfo Lopes de Paiva; Azevedo, Eduardo Pereira de; Queiroz, Dinalva Brito de; Botelho, Marco Antônio; Rêgo, Amália Cinthia Meneses do; Araújo Filho, Irami; Barboza, Carlos Augusto Galvão; Nascimento Júnior, Expedito Silva do; Costa, Miriam Stela Maris de Oliveira; Cavalcante, Jeferson de Sousa; Guzen, Fausto Pierdoná
Mesenchymal cells (MCs) exhibit great regenerative potential due to their intrinsic properties and ability to restore tissue function, either directly through transdifferentiation or indirectly through paracrine effects. This study aimed to evaluate morphometric and phenotypic changes in MCs grown with facial nerve-conditioned medium in the presence or absence of fibroblast growth factor 2 (FGF-2). For quantitative phenotypic analysis, the expression of GFAP, OX-42, MAP-2, β-tubulin III, NeuN, and NF-200 was analyzed by immunocytochemistry. Cells cultured with facial nerve-conditioned medium in the presence of FGF-2 expressed GFAP, OX-42, MAP-2, β-tubulin III, NeuN, and NF-200. On average, the area and perimeter of GFAP-positive cells were higher in the group cultured with facial nerve-conditioned medium compared to the group cultured with conditioned medium and FGF-2 (p=0.0001). This study demonstrated the plasticity of MCs for neuronal and glial lineages and opens up new research perspectives in cell therapy and trans.differentiation
Fecal androgen levels in common marmoset (Callithrix jacchus) males living in captive family groups
(2005) Castro, D. C.; Sousa, Maria Bernardete Cordeiro de

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