Navegando por Autor "Xavier, Maíra de Araújo Barros"
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Artigo Analysis of the immunohistochemical expression of ghrelin in the gastric mucosa and correlation with weight loss after sleeve gastrectomy(Springer, 2022-09-23) Quinino, Reynaldo Martins e; Barbosa, André Luis Costa; Xavier, Maíra de Araújo Barros; França, Romero de Lima; Freitas, Mirella Patrícia Cruz de; Goldenberg, Alberto; https://orcid.org/0000-0002-4284-2543Introduction Sleeve gastrectomy is one of the main techniques used to treat severe obesity. The study of the immunohistochemical expression of ghrelin in the gastric mucosa has already been related to weight loss and can be a promising method to predict the surgical outcome. Purpose To analyze the immunohistochemical expression of ghrelin in the gastric mucosa and its correlation with weight loss, comorbidities, and infammatory changes after sleeve gastrectomy. Methods Thirty-fve patients submitted to sleeve gastrectomy were evaluated, 29 of whom were female (82.9%), with a mean age of 35.2 years and an average body mass index of 38.1 kg/m2 . Endoscopic samples of the mucosa were collected, whose ghrelin expression was evaluated in a semi-quantitative way through the stained antibody area. These data were correlated with weight loss at 3, 6, and 12 months and with the control of comorbidities, and infammatory alterations. Results The average total weight loss (TWL%) was 17.7, 26.4, and 32.1%, respectively, at 3, 6, and 12 months. A negative correlation was found between the immunohistochemical expression of ghrelin in the endoscopic biopsy of the fundus and weight loss at 3 (s= −0.536; p=0.001) and 6 months (s= −0.339; p=0.047). Conclusion The immunohistochemical expression of ghrelin in the mucosa of the gastric fundus was negatively correlated with early weight loss after sleeve gastrectomy