Navegando por Autor "Takamori, J. T."

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Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features
(Fundação de Pesquisas de Ribeirão Preto, 2017-11) Takamori, J. T.; Santos, Marcelo dos; Peterle, G. T.; Rossi, L.; Curioni, O. A.; Gazito, D.; Maia, L. L.; Louro, I. D.; Oliveira, M. M. de; Santos, J. G. dos; Moyses, R. A.; Cury, P. M.; Toporcov, T. N.; Kanda, J. L.; Silva, A. M. A. da; Carvalho, M. B. de
Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of oral cancer by interfering with mechanisms of DNA synthesis and repair. From a genetic standpoint, variant alleles in genes encoding the enzymes of alcohol (CYP2E1 and ADH) and acetaldehyde (ALDH2) metabolism may play an important role in the genesis of oral cancer. This study aimed to assess the relation of polymorphisms ADH1B (rs1229984 and rs2066702), ADH1C (rs698), ALDH2 (rs671) and CYP2E1 96bp insertion and the risk of squamous cell carcinoma of the mouth floor, as well as its clinicopathological and prognostic characteristics in relation to alcohol consumption. Our sample group was made of 301 patients, with 159 controls without a previous history of cancer and 142 patients with oral cancer. Genomic DNA was extracted from peripheral blood samples and genotypes were determined by PCR-RFLP. Our results suggest that the presence of ALDH2 Lys504 allele and 96bp insertion CYP2E1 were significantly associated with oral cancer risk. ADH1C gene Ile350 allele was associated with the presence of positive lymph nodes, and lymphatic invasion was related to the presence of polymorphic alleles ADH1B*1, ADH1C Ile350 and ALDH2 Lys504. In conclusion, these results reveal potential markers of oral cancer risk and behavior
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
(Fundação de Pesquisas de Ribeirão Preto, 2015-11-24) Rodrigues, P. R. S.; Maia, L. L.; Santos, Marcelo dos; Peterle, G. T.; Alves, L. U.; Takamori, J. T.; Souza, R. P.; Barbosa, W. M.; Mercante, A. M. C.; Nunes, F. D.; Carvalho, M. B.; Tajara, E. H.; Louro, I. D.; Silva-Conforti, A. M. A.
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunity, differentiation, and cell proliferation. The LEPR Gln223Arg polymorphism has been reported to alter receptor function and expression, both of which have been related with prognostics in several tumor types. Furthermore, several studies have shown a relationship between the Gln223Arg polymorphism and tumor development, and its role in oral and oropharyngeal squamous cell carcinoma is now well understood. In this study, 315 DNA samples were used for LEPR Gln223Arg genotyping and 87 primary oral and oropharyngeal squamous cell carcinomas were used for immunohistochemical expression analysis, such that a relationship between these and tumor development and prognosis could be established. Homozygous LEPR Arg223 was found to be associated with a 2-fold reduction in oral and oropharyngeal cancer risk. In contrast, the presence of the Arg223 allele in tumors was associated with worse disease-free and disease-specific survival. Low LEPR expression was found to be an independent risk factor, increasing the risk for lymph node metastasis 4-fold. In conclusion, the Gln223Arg polymorphism and LEPR expression might be valuable markers for oral and oropharyngeal cancer, suggesting that LEPR might serve as a potential target for future therapies

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Navegando por Autor "Takamori, J. T."