Navegando por Autor "Tajara, Eloiza H."
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Artigo ATM, BCL2, and TGFb gene polymorphisms as radiotherapy outcome biomarkers in head and neck squamous cell carcinoma patients(Mary Ann Liebert, 2017-12) Agostini, Lidiane Pignaton; Stur, Elaine; Garcia, Fernanda M.; Ventorim, Diego P.; Reis, Raquel S. dos; Dettogni, Raquel S.; Santos, Eldamária V. W. dos; Peterle, Gabriela T.; Maia, Lucas L.; Mendes, Suzanny O.; Carvalho, Marcos B. de; Tajara, Eloiza H.; Paula, Flavia de; Santos, Marcelo dos; Silva, Adriana M. A. da; Louro, Iúri DrumondAims: Polymorphisms in cell cycle genes are considered prognostic as radiosensitivity markers in patients with head and neck squamous cell carcinoma. Therefore, we aimed to investigate the relationship of ATM 5557G>A, ATM IVS62 + 60G>A, TP53 215G>C, BCL2-938C>A, TGFb-509C>T, and TGFb 29C>T with radiotherapy response. Materials and Methods: Genotyping was performed by polymerase chain reaction followed by restriction fragment length polymorphism in 210 patients with oral cavity/oropharyngeal carcinoma and 101 patients with laryngeal tumors. Results: In irradiated oral cavity/oropharyngeal tumors, the ATM IVS62 + 60G>A AA genotype significantly increased local recurrence risk (odds ratio [OR] = 4.43; confidence interval [CI] = 1.22–16.13) and the BCL2- 938C>A C allele and the TGFb-509C>T T allele were associated with worse disease-specific survival (hazar dratio [HR] = 0.46; CI = 0.24–0.90 and HR = 2.20; CI = 1.12–4.29, respectively). In irradiated laryngeal carcinoma, the TGFb 29C>T C allele was associated with increased local recurrence risk (OR = 0.09; CI = 0.02–0.53), death rate (OR = 0.18; CI = 0.04–0.86), and worse local disease-free and disease-specific survival rates (HR = 0.13; CI = 0.03–0.59 and HR = 0.21; CI = 0.07–0.60, respectively), while the BCL2-938C>A C allele was related to a worse disease-specific survival (HR = 0.32; CI = 0.12–0.83). Discussion: These results can help individualize treatment according to a patient’s genetic markers. We demonstrated that ATM IVS62 + 60G>A, TGFb 29C>T, TGFb-509C>T, and BCL2-938C>A can function as biomarkers of tumor radiosensitivity, being candidates for a predictive genetic profile of radiotherapy responseArtigo Elemental characterization of oral cavity squamous cell carcinoma and its relationship with smoking, prognosis and survival(Nature Research, 2020-06-25) Archanjo, Anderson Barros; Assis, Arícia Leone Evangelista Monteiro de; Oliveira, Mayara Mota de; Mendes, Suzanny Oliveira; Borçoi, Aline Ribeiro; Maia, Lucas de Lima; Souza, Rafael Pereira de; Cicco, Rafael de; Saito, Kelly Cristina; Kimura, Edna Teruko; Carvalho, Marcos Brasilino de; Nunes, Fabio Daumas; Tajara, Eloiza H.; Santos, Marcelo dos; Nogueira, Breno Valentim; Trivilin, Leonardo Oliveira; Pinheiro, Christiano Jorge Gomes; Silva, Adriana Madeira Álvares daOral cancer squamous cell carcinoma (OCSCC) mainly affects individuals aged between 50 and 70 years who consume tobacco and alcohol. Tobacco smoke contains hundreds of known toxic and carcinogenic molecules, and a few studies have sought to verify the relationship of such trace elements as risk or prognostic factors for head and neck cancer. We obtained 78 samples of tumor tissues from patients with OCSCC, and performed a qualitative elemental characterization using the micro X-Ray Fluorescence technique based on synchrotron radiation. We found the presence of magnesium, phosphorus, sulfur, chlorine, potassium, calcium, chromium, manganese, iron, zinc, cobalt, nickel, copper, arsenic and bromine in OCSCC samples. Magnesium, chlorine, chromium, manganese, nickel, arsenic and bromine are associated with smoking. We observed a significant association between relapse and chlorine and chromium. The presence of chlorine in the samples was an independent protective factor against relapse (OR = 0.105, CI = 0.01–0.63) and for best disease-free survival (HR = 0.194, CI = 0.04–0.87). Reporting for the first time in oral cancer, these results suggest a key relationship between smoking and the presence of certain elements. In addition, chlorine proved to be important in the context of patient prognosis and survival