Navegando por Autor "Silva, Gyl Eanes Barros"
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Artigo Antibrush border antibody disease: a case report and literature review(Elsevier, 2021) Almeida, Jose Bruno de; Brito, Laíse Pereira Arcoverde Fechine; Guedes, Felipe Leite; Vale, Pedro Henrique Cavalcante; Santos, Rivaldo Pereira; Martins, Sílvia Queiroz Santos; Dantas, Gleiko Yuri de Figueredo; Wanderley, David; Araújo, Stanley de Almeida; Silva, Gyl Eanes BarrosAnti-brush border antibody (ABBA) disease, also called anti–low-density lipoprotein receptor-related protein 2 (anti-LRP2) nephropathy, occurs due to the formation of antibodies against brush border antigens of the renal proximal convoluted tubule. We report a case of ABBA disease in a male farmer in his 30s who presented with 2 years of polyuria, dysuria, nocturia, and urinary urgency. He described a history of long-term occupational exposure to pesticides and silica, evolving into possible pneumoconiosis, and prior pulmonary tuberculosis. At presentation, he had reduced kidney function (serum creatinine 3.6 mg/dL) with hyponatremia, hypokalemia, hypophosphatemia, a normal anion gap, metabolic acidosis, and respiratory acidosis, and 2.2 g/day of urine proteinuria. The kidney biopsy was consistent with ABBA, showing amorphous immune-deposits in the tubular basement membrane and strong positivity on indirect immunofluorescence in the brush border of the proximal tubules. The trigger for production of ABBA is still unknown, but it may be associated with chronic conditions such as pulmonary tuberculosis and occupational exposures such as silica and pesticides, as seen in the patient in this report. Most cases do not respond to immunosuppression, and the prognosis is poor.Artigo Collapsing glomerulopathy: a review by the collapsing brazilian consortium(Frontiers in medicine, 2022) Almeida, Jose Bruno de; Cutrim, Érico Murilo Monteiro; Neves, Precil Diego Miranda de Meneses; Campos, Marcos Adriano Garcia; Wanderley, Davi Campos; Teixeira Júnior, Antonio Augusto Lima; Muniz, Monique Pereira Rêgo; Ladchumananandasivam, Francisco Rasiah; Gomes, Orlando Vieira; Vasco, Rafael Fernandes Vanderlei; Brito, Dyego José de Araújo; Lages, Joyce Santos; Salgado-Filho, Natalino; Guedes, Felipe Leite; Magalhães, Marcelo; Araújo, Stanley de Almeida; Silva, Gyl Eanes BarrosCollapsing glomerulopathy (CG) is a clinicopathologic entity characterized by segmentar or global collapse of the glomerulus and hypertrophy and hyperplasia of podocytes. The Columbia classification of 2004 classified CG as a histological subtype of focal segmental glomerulosclerosis (FSGS). A growing number of studies have demonstrated a high prevalence of CG in many countries, especially among populations with a higher proportion of people with African descent. The present study is a narrative review of articles extracted from PubMed, Medline, and Scielo databases from September 1, 2020 to December 31, 2021. We have focused on populational studies (specially cross-sectional and cohort articles). CG is defined as a podocytopathy with a distinct pathogenesis characterized by strong podocyte proliferative activity. The most significant risk factors for CG include APOL1 gene mutations and infections with human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. CG typically presents with more severe symptoms and greater renal damage. The prognosis is notably worse than that of other FSGS subtypes