Navegando por Autor "Santos, W.B."
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Artigo False-alarm and non-detection probabilities for on-line quality control via HMM(International Journal of Mathematical Analysis, 2012) Dorea, C.C.Y.; Gonçalves, C.R.; Medeiros, P.G.; Santos, W.B.On-line quality control during production calls for monitoring produced items according to some prescribed strategy. It is reasonable to assume the existence of system internal non-observable variables so that the carried out monitoring is only partially reliable. In this note, under the setting of a Hidden Markov Model (HMM) and assuming that the evolution of the internal state changes are governed by a two-state Markov chain, we derive estimates for false-alarm and non-detection malfunctioning probabilities. Kernel density methods are used to approximate the stable regime density and the stationary probabilities. As a side result, alternative monitoring strategies are proposed.Artigo Lithium and valproate prevent methylphenidate-induced mania-like behaviors in the hole board test(Elsevier, 2016-08-26) Souza, L.S.; Soares, Bruno Lobão; Silva, E.F.; Santos, W.B.; Asth, L.; Soares-Rachetti, V.P.; Medeiros, I.U.; Gavioli, E.C.Manic bipolar is diagnosed by psychomotor agitation, increased goal-directed activity, insomnia, grandiosity, excessive speech, and risky behavior. Animal studies aimed to modeling mania are commonly based in psychostimulants-induced hyperlocomotion. The exploration of other behaviors related with mania is mandatory to investigate this phase of bipolar disorder in animals. In this study, the hole board apparatus was suggested for evaluating mania-like behaviors induced by the psychostimulant methylphenidate. The treatment with methylphenidate (10 mg/kg, ip) increased locomotion in the open field test. The pretreatment with lithium (50 mg/kg, ip) and valproate (400 mg/kg, ip) significantly prevented the hyperlocomotion. In the hole-board test, methylphenidate increased interactions with the central and peripheral holes and the exploration of central areas. Lithium was more effective than valproate in preventing all the behavioral manifestations induced by the psychostimulant. These findings were discussed based on the ability of methylphenidate-treated mice mimicking two symptoms of mania in the hole board test: goal-directed action and risk-taking behavior. In conclusion, the results point to a new approach to study mania through the hole board apparatus. The hole board test appears to be a sensitive assay to detect the efficacy of antimanic drugs.