Navegando por Autor "Roque, A. A."

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Extraction of bioactive alkaloids from Melocactus zehntneri using supercritical fluid
(Elsevier, 2017-11) Brandão, Gustavo Henrique Azevedo; Rigo, Graziela Vargas; Roque, A. A.; Souza, A. C. D.; Scopel, Marina; Nascimento, Cláudio Augusto Oller do; Tasca, Tiana; Courtial, Camila Gambini Pereira; Giordani, Raquel Brandt
The purpose of this study was to extract alkaloids from Melocactus zehntneri aerial parts using supercrit-ical fluid extraction (SFE) and to evaluate their cytotoxic action. SFE process was compared to differentclassical low pressure solvent extraction processes in terms of global yield, extract profile and biologicalactivity. Two specimens of M. zehntneri were evaluated: young and adult aerial parts. The extracts wereanalyzed by HPLC-UV/DAD as well as they were evaluated against HMVII and Trichomonas vaginalis. Theresults indicated a qualitative difference in chromatographic profile of the extracts. Finally, the resultspoint out the potential of the extract obtained from aerial parts of young specimens (Y-RM) through SFEat 300 bar/55◦C against T. vaginalis and HMVII, presenting relevant information for development of newstudies about cytotoxic

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