Navegando por Autor "Pinto, Leao Pereira"
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Artigo Prevention of oral lesions in children with acute lymphoblastic leukemia(ELSEVIER, 2006) Pinto, Leao Pereira; Souza, Lelia Batista de; Gordón-Núñez, Manuel Antonio; Soares, Rosilene Calasanz; Costa, Edja Maria Melo de Brito; Aquino, Ana Rafaela Luz de; Fernandes, Maria ZéliaAcute lymphoblastic leukemia (ALL) is the most common form of cancer in children and is responsible for severe stomatologic complications. Treatment consists of four phases of chemotherapy, the main side effect of methotrexate, the drug most used during the intensification phase, is oral mucositis. OBJECTIVE: To evaluate the clinical aspects of the oral mucosa of children with ALL and to determine the effect of 0.12% chlorhexidine gluconate on the prevention of stomatologic complications in these patients. PATIENTS AND METHODS: Thirty-three children treated for ALL ranging in age from 2 to 15 years, without distinction of gender or race, were submitted to visual examination, digital palpation of the oral mucosa and cytologic examination of the buccal mucosa, and divided into two groups: group I consisted of 23 children using an oral solution of 0.12% chlorhexidine gluconate twice a day, and group II consisted of 10 children who did not receive this solution. All children received daily oral hygiene care guided by the dentist throughout treatment. RESULTS: Mucositis was observed in six children of group I and eight of group II, and was characterized by erythema, edema and ulcers. Uniform cytologic findings were obtained for the two groups, with a clear predominance of cells of the intermediate layer in all smears, in addition to a perinuclear halo in 18% of the smears. CONCLUSION: The present results suggest that systematic preventive treatment with 0.12% chlorhexidine gluconate and oral hygiene care reduce the occurrence of oral complications in children with ALL undergoing antineoplastic chemotherapy.Artigo Prognostic factors of oral squamous cell carcinoma in young patients: a systematic review(Elsevier, 2017) Souza, Dyego Leandro Bezerra de; Morais, Everton Freitas de; Mafra, Rodrigo Porpino; Pinto, Leao Pereira; Gonzaga, Amanda Katarinny Goes; Silveira, Ericka Janine Dantas da; https://orcid.org/0000-0001-8426-3120Purpose: The objective of this review was to identify clinical and pathologic factors related to the prognosis of oral squamous cell carcinoma in young patients. Materials and Methods: We conducted a literature search of articles indexed in PubMed (MEDLINE), Scopus, and Science Direct. Prospective and retrospective cohort studies published in English, Portuguese, or Spanish were included. An age threshold of 45 years was established for the purpose of selection. Results: A total of 14,746 articles were retrieved, and 11 relevant studies were selected. The total sample comprised 2,317 patients, and there was a predominance of male patients. The tongue was the most commonly affected anatomic site. The prevalence of tobacco use ranged from 9.0 to 85.7%, and alcohol consumption was observed in 26.1 to 78.6% of the cases studied. Tobacco use and alcohol consumption were the main risk factors in young patients. Regarding tumor-node-metastasis stage, most studies found a predominance of cases diagnosed in early stages (I and II). The studies varied widely in terms of histologic grade of malignancy and locoregional recurrences. Regional lymph node metastases had a negative impact on overall and specific survival rates. Conclusions: Our findings suggest a lack of solid evidence of differences in the prognosis of oral squamous cell carcinoma between young and older patients. This may reflect variations in the samples studied, including the prevalence of risk factors, access to health care services, and time since diagnosis