Navegando por Autor "Phillips, Susan P."
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Artigo Association between C-reactive protein and physical performance in older populations: results from the International Mobility In Aging Study (IMIAS)(Oxford University Press (OUP), 2016-01-28) Sousa, Ana Carolina Patrício Albuquerque; Zunzunegui, Maria-Victoria; Li, Annie; Phillips, Susan P.; Guralnik, Jack M.; Guerra, Ricardo OliveiraBackground and objective: C-reactive protein (CRP) is a widely used cardiovascular risk marker, but questions remain about its role in the disability process in old age. This study examines the associations between CRP levels and physical performance in old age in different societies. Methods: data were collected during the baseline survey of IMIAS in 2012 in Kingston (Canada), Saint-Hyacinthe (Canada), Manizales (Colombia) and Natal (Brazil). Approximately 200 men and 200 women aged 65–74 were recruited at each site. CRP was assessed using a high sensitivity assay and categorised as low (<1 mg/l), moderate (1–3 mg/l), high (3–10 mg/l) and very high (≥10 mg/l). Participants were interviewed at home; blood pressure, weight and height were measured. Physical function was assessed with the Short Physical Performance Battery (SPPB) and hand grip strength. Data were analysed using descriptive statistics, bivariate analysis (χ²) and linear or logistic regression. Results: CRP was significantly associated with low hand grip strength and poor physical performance in bivariate analyses. Hand grip strength association with CRP disappeared after adjustment by socioeconomic factors and health behaviours. The odds of poor physical function was OR = 2.67 [95% CI 1.43–4.99] comparing the highest and lowest CRP categories after adjustment by relevant covariates. The three SPPB components were assessed separately. Graded associations between low CRP and faster gait speed and shorter time to rise from a chair were observed in adjusted models. Association between impaired balance and CRP was attenuated after adjustment by relevant covariates, OR = 1.15 [0.65–2.04]. Conclusions: CRP could be a possible pathway from inflammation to physical decline in older populationsArtigo Lifecourse adversity and physical performance across countries among men and women aged 65-74(Public Library of Science, 2014-08-07) Sousa, Ana Carolina Patrício de Albuquerque; Guerra, Ricardo Oliveira; Tu, Mai Thanh; Phillips, Susan P.; Guralnik, Jack M.; Zunzunegui, Maria-VictoriaBackground: This study examines the associations between lifecourse adversity and physical performance in old age in different societies of North and South America and Europe. Methods: We used data from the baseline survey of the International Study of Mobility in Aging, conducted in: Kingston (Canada), Saint-Hyacinthe (Canada), Natal (Brazil), Manizales (Colombia) and Tirana (Albania). The study population was composed of community dwelling people between 65 and 74 years of age, recruiting 200 men and 200 women at each site. Physical Performance was assessed with the Short Physical Performance Battery (SPPB). Economic and social adversity was estimated from childhood adverse events, low education, semi-skilled occupations during adulthood and living alone and insufficient income in old age. Results: A total of 1995 people were assessed. Low physical performance was associated with childhood social and economic adversity, semi-skilled occupations, living alone and insufficient income. Physical performance was lower in participants living in Colombia, Brazil and Albania than in Canada counterparts, despite adjustment for lifecourse adversity, age and sex. Conclusions: We show evidence of the early origins of social and economic inequalities in physical performance during old age in distinct populations and for the independent and cumulative disadvantage of low socioeconomic status during adulthood and poverty and living alone in later life