Navegando por Autor "Nunes, Ana Clara de França"

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Anti-inflammatory agents as modulators of the inflammation in adipose tissue: a systematic review
(Plos One, 2022) Morais, Ana Heloneida de Araujo; Nascimento, Sara Sayonara da Cruz; Queiroz, Jaluza Luana Carvalho de; Medeiros, Amanda Fernandes de; Nunes, Ana Clara de França; Piuvezam, Grasiela; Maciel, Bruna Leal Lima; Passos, Thais Souza; https://orcid.org/0000-0002-6460-911X
Obesity is characterized by an adipose tissue mass expansion that presents a risk to health, associated with a chronic increase in circulating inflammatory mediators. Anti-inflammatory agents are an obesity alternative treatment. However, the lack of effective agents indicates the need to assess the mechanisms and identify effective therapeutic targets. The present work identified and described the mechanisms of action of anti-inflammatory agents in adi pose tissue in experimental studies. The review was registered in the International Prospec tive Registry of Systematic Reviews (PROSPERO—CRD42020182897). The articles’ selection was according to eligibility criteria (PICOS). The research was performed in PubMed, ScienceDirect, Scopus, Web of Science, VHL, and EMBASE. The methodological quality evaluation was assessed using SYRCLE. Initially, 1511 articles were selected, and at the end of the assessment, 41 were eligible. Among the anti-inflammatory agent classes, eight drugs, 28 natural, and five synthetic compounds were identified. Many of these anti inflammatory agents act in metabolic pathways that culminate in the inflammatory cytokines expression reduction, decreasing the macrophages infiltration in white and adipose tissue and promoting the polarization process of type M1 to M2 macrophages. Thus, the article cla rifies and systematizes these anti-inflammatory agents’ mechanisms in adipose tissue, pre senting targets relevant to future research on these pathways.
Effect of carotenoid encapsulation on antioxidant activities: a protocol for systematic review
(Medicine, 2020) Morais, Ana Heloneida de Araujo; Queiroz, Jaluza Luana Carvalho de; Medeiros, Isaiane; Piuvezam, Grasiela; Nunes, Ana Clara de França; Gomes, Camila Carvalho; Maciel, Bruna Leal Lima; Passos, Thaís Souza; https://orcid.org/0000-0002-6460-911X
Background: Carotenoids play essential roles in human health, such as antioxidant activity, and therefore can decrease free radicals oxidation action, preventing numerous diseases. However, these compounds have an unstable nature, turning them susceptible to adverse conditions in food processing and storage. Thereby the search for alternatives that maintain and enhance carotenoid antioxidant function, such as encapsulation, has grown. The objective of this study was to establish a systematic review protocol to evaluate the effect of different encapsulation techniques on the antioxidant action of carotenoids, evaluating which one is the best and safest, and their role in enhancing the antioxidant activity. Methods: This protocol was guided by the preferred reporting items for protocols for systematic reviews and meta-analyzes. The databases to be searched are PubMed, EMBASE, Scopus, ScienceDirect, and Web of Science. Experimental studies conducted in rats and mice (in vivo) of both sexes and ages, evaluating the use of encapsulated and crude carotenoids will be included in the systematic review. The characteristics of the studies, the experimental model, and the main results will be described, and the risk of bias assessment will be evaluated. Three independent reviewers will proceed with the selection of studies, data extraction, and methodological quality assessment. A narrative synthesis will be made for the included studies. Besides, if sufficient qualitative data is available, a meta-analysis will be conducted. I2 statistics will be used to assess heterogeneity. Results: This protocol will guide the production of a systematic review that can determine the effect of different encapsulation techniques and encapsulating agents on the antioxidant action of carotenoids. Thus, it will enable the determination of the best encapsulation techniques to promote the preservation and increase of the antioxidant activity, contributing to future research that may reproduce the best carotenoid encapsulation technique in an animal model. Conclusion: The systematic review to be produced from this protocol will provide support for the construction of research that evaluates the effect of encapsulation on the antioxidant function of carotenoids and its possible application as a nutraceutical, considering that this functionality is directly associated with health promotion. Record of systematic review: This review was recorded in the International Register of Prospective Systematic Reviews on January 22, 2020 (registration: CRD42020142065). Available at: https://www.crd.york.ac.uk/prospe /display_record.php?ID=CRD42020142065 Abbreviations: CAPES = coordination of improvement of higher education personnel, CNPQ = National Council for Scientific and Technological Development, MeSH = Medical Subject Headings
Encapsulation techniques perfect the antioxidant action of carotenoids: a systematic review of how this effect is promoted
(Elsevier, 2022) Queiroz, Jaluza Luana Carvalho de; Medeiros, Isaiane; Trajano, Aslan Costa; Piuvezam, Grasiela; Nunes, Ana Clara de França; Passos, Thais Souza; Morais, Ana Heloneida de Araújo; https://orcid.org/0000-0002-6460-911X
Considering that antioxidant activities are directly related to carotenoid functionalities, it is necessary to use techniques that promote the stability of these natural pigments. This systematic review aimed to gather evidence on the effect of encapsulation techniques on the maintenance and/or enhancement of the antioxidant activity of carotenoids. The study was registered in PROSPERO (CRD42020142065). Searches were performed in PubMed, Embase, Virtual Health Library, Scopus, ScienceDirect, and Web of Science databases. Assessment of methodo logical quality was performed using OHAT. A total of 1577 articles were selected, resulting in 20 eligible studies. Overall, results showed that the mechanisms involved are related to the emergence of new chemical interactions, increased surface area, and the controlled release of carotenoids. Thus, evidence proved that encapsulation could preserve and/or enhance bioactivities of carotenoids, allowing the use in foods to promote benefits on population health
Is rituximab effective for systemic sclerosis? A systematic review and meta-analysis
(Springer, 2021) Piuvezam, Grasiela; Caldas, Marina Maria Vieira de Figueiredo; Azevedo, Kesley Pablo Morais de; Nunes, Ana Clara de França; Oliveira, Victor Hugo de; Pimenta, Isac Davidson Santiago Fernandes; Araújo, Isabela Dantas Torres de; Bezerra Neto, Francisco Alves; Oliveira, Ana Katherine da Silveira Gonçalves de; https://orcid.org/0000-0002-2343-7251
Background: Systemic sclerosis (SSc) is a clinically complex and challenging disease, that leads to skin fibrosis. Its most frequent complication is interstitial lung disease (ILD), which leads to a worse prognosis. In this situation, cyclophosphamide is considered the gold standard for its treatment, despite the controversies regarding its efficacy and toxicity. However, studies using rituximab (RTX) have shown that this drug may be a promising therapeutic option. Objectives: This paper objective was to analyze the scientific evidence on the RTX effects on SSc. Methods: A systematic review (SR) was performed including clinical trials (CTs) on the use of RTX in SSc, published up to May 2020. The studies were identified through systematic searches in bibliographic databases using a predefined search strategy. The following databases were used: PUBMED, SCOPUS, SCIELO, LILACS, SCIENCE DIRECT, WEB OF SCIENCE, COCHRANE, WHOLIS, PAHO and EMBASE. Also, a manual search was performed. The methodological quality of the studies was determined using Jadad scale, Risk of Bias Tool (RoB 2.0) and Risk of Bias in Non-Randomized Studies - of Interventions tool (ROBINS-I). A meta-analysis of the randomized CTs was performed, using Review Manager. Results: Ten CTs were included in this SR. Of these, three were randomized and seven were non-randomized. Five showed a statistically significant improvement in forced vital capacity (FVC) at some time during follow-up. Regarding the skin, eight studies showed statistically significant improvements according toa the modified Rodnan skin score. The meta-analysis found positive effects of RTX in SSc, with a statistical significance for lung disease. Conclusion: Rituximab is a promising strategy for the SSc-associated ILD and cutaneous fibrosis treatment. PROSPERO registration number: CRD42019132018
Media and scientific communication about the COVID-19 pandemic and the repercussions on the population's mental health
(Lippincott, Williams & Wilkins, 2020-12-11) Pimenta, Isac Davidson Santiago Fernandes; Mata, Ádala Nayana de Sousa; Braga, Liliane Pereira; Medeiros, Gidyenne Christine Bandeira Silva de; Azevedo, Kesley Pablo Morais de; Bezerra, Isaac Newton Machado; Segundo, Victor Hugo de Oliveira; Nunes, Ana Clara de França; Santos, Gilberto Martins; Grosseman, Suely; Nicolás, Ismael Martínez; Piuvezam, Grasiela
Background: Good communication strategies are essential in times of crisis, such as the coronavirus pandemic. The dissemination of inaccurate information and the need for social isolation to control coronavirus disease 2019 (COVID-19) have shown a negative impact on the population, causing damage to mental health, with the appearance or worsening of symptoms of stress, fear, anxiety, and depression. Thus, the systematic review study is intended to gather evidence on the impact of information about COVID-19 on the mental health of the population. Methods: This systematic review protocol is conducted using the guidelines of the preferred reporting items for systematic reviews and meta-analyses protocols and the Cochrane Handbook for Systematic Reviews of Interventions. The review aims to include published studies that address the exposure of the general population to information about COVID-19, through observational and experimental studies, which consider the following outcomes: fear, stress, anxiety, and depression. Thus, a comprehensive research strategy will be conducted in the following databases: PubMed / Medline, Scopus, Web of Science, EMBASE, Science Direct, CINAHL, PsycINFO and Cochrane Central Register of Controlled Trials (CENTRAL). Two independent reviewers will perform all procedures, such as study selection, data collection, and methodological evaluation. Disagreements will be forwarded to a third reviewer. RevMan 5.3 software will be used for data analysis. Results: This systematic review will provide evidence of the influence of access to and consumption of media and scientific information about COVID-19 on the mental health of the population. It will consider information about the characterization of the study and the population studied, clinical and epidemiological information on mental health, and data on access to and consumption of media and scientific information. Discussion: The results should inform about the consequences of communication about the new coronavirus on the emergence or worsening of psychological and psychiatric symptoms, allowing to develop strategies to achieve effective communication of information to promote the mental health of the population. Systematic review registration number: PROSPERO CRD42020182918 Abbreviation: COVID-19 = coronavirus disease 2019
Nutritional supplementation of vitamin A and health-related outcomes in patients with multiple sclerosis: a protocol for a systematic review and meta-analysis of randomized clinical trials
(Medicine, 2019) Piuvezam, Grasiela; Nunes, Ana Clara de França; https://orcid.org/0000-0002-2343-7251
Background: Multiple sclerosis (MS) is a chronic immune mediated disease which affects the central nervous system (CNS), having a substantial financial, functional, and quality of life (QOL) impact on these people. The vitamin A supplementation has been studied as a therapeutic possibility for in MS. Therefore, the objective of this protocol is to build an outline for a future systematic review, which will provide up-to-date available evidence about the clinical impact of nutritional supplementation of vitamin A in the outcomes related to the symptoms in patients with this pathology. Methods: The search will be performed in the following databases: PubMed, Embase, Scopus, cinahl, Scielo, Web of Science, the Cochrane Library and Science Direct, randomized clinical trials published until May 2019 that evaluate the relationship of the supplementation of vitamin A and health-related outcomes in patients with MS will be included. Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) will be used to outline the protocol, and PRISMA to the systematic review. Undergraduate handbook of quality of evidence and strength of recommendations for decision making in health (GRADE) will be used to assess the quality of evidence and the strength of the recommendation, and the JADAD scale to assess the internal validity of selected studies. For the extraction of all the data found a database in Microsoft Excel will be created. For the summary of the findings the Cochrane Collaboration Handbook recommendations will be used, and for the meta-analysis standard statistical techniques the RevMan software will be used. Results: In this study, we hope to find a considerable number of articles presenting evidence about the effectiveness of vitamin A supplementation in patients with MS. Conclusion:Currently, many lines of evidence have been produced when it comes to the use of food supplements. This systematic review proposal might provide recent, important, and trusted information for better treatment of patients. Record of systematic review: This review was recorded in the International Register of Prospective Systematic Reviews (PROSPERO) on the January 30, 2019 (registration: CRD42019121757). Available at: http://www.crd.york.ac.uk/PROSPERO/ display_record.php?ID=CRD42019121757. Abbreviations: BBB = blood–brain barrier, CENTRAL = Cochrane Central Register of Controlled Trials, CNS = central nervous system, EDSS = expanded disability status scale of Kurtzke, EMBASE = Excerpta Medica Database, GRADE = undergraduate handbook of quality of evidence and strength of recommendations for decision making in health, MESH = medical subject headings, MS = multiple sclerosis, PRISMA = Preferred Reporting Items for Systematic reviews and Meta-Analyse, PROSPERO = Prospective Register of Systematic Reviews, QOL = quality of life, RA = retinoic acid, RAR = retinoic acid receptor, RCT = randomized and controlled clinical trials, RR = relative risk
The control and prevention of COVID-19 transmission in children: a protocol for systematic review and meta-analysis
(Lippincott, Williams & Wilkins, 2020-07-31) Medeiros, Gidyenne Christine Bandeira Silva de; Nunes, Ana Clara de França; Azevedo, Kesley Pablo Morais de; Oliveira Segundo, Victor Hugo de; Santos, Gilberto Martins; Mata, Ádala Nayana de Sousa; Pimenta, Isac Davidson; Bezerra, Isaac Newton Machado; Braga, Liliane Pereira; Capucho, Helaine Carneiro; Piuvezam, Márcia Regina; Barbosa Filho, Valter Cordeiro; Leitão, José Carlos; Martínez, Daniel Guillén; Piuvezam, Grasiela
Background: The pandemic following the rapid spread of the new SARS-CoV-2 virus has hit all continents and caused thousands of deaths worldwide. Evidence has been published on epidemiological and clinical characteristics of population groups considered at risk; however, information for the other population groups, especially for the child population, is needed. In this context, this protocol describes a systematic review that will aim to identify the evidence on control and prevention of COVID-19 transmission among children and adolescents, as well as to describe the epidemiological profile and clinical and immunological characteristics of COVID-19 in this population. Methods: This protocol will be developed in accordance with PRISMA-P. The searches will be conducted in PubMed, Web of Science, ScienceDirect, EMBASE, and Scopus, seeking clinical trials. Observational studies and case reports with Children and adolescents ( 19 years) infected with SARS-CoV-2 will be included whether they report information on the control of prevention and COVID-19 transmission. Two independent researchers will perform the selection of articles, removal of duplication, and screening by Rayyan QCRI application. Cochrane’s RoB 2.0, ROBINS-I, and CASP tools will be used to assess the risk of bias. Meta-analysis, subgroup analyses, and/or descriptive analyses will be carried out based on the data conditions included. Results: A high-quality synthesis of the available evidences on the epidemiological profile, the clinical and immunological characteristics involved in children, and adolescents diagnosed with COVID-19, as well as the participation of this population in the transmission dynamics of SARS-CoV-2 will be provided. Conclusion: This systematic review has an important relevance in the current context because it has a great potential to help the development of new control and prevention strategies in the pediatric population. Record of systematic review: CRD42020179263. Abbreviations: CASP = Critical Appraisal Skills Program, COVID-19 = Corona Virus Disease (2019), PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analyses, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, RoB = Risk of bias, ROBINS-I = Risk of Bias in Non-Randomised Studies – of Interventions, SARS-CoV-2 = Severe Acute Respiratory Syndrome Coronavirus 2
Vitamina A e sintomas da Esclerose Múltipla: revisão sistemática de estudos epidemiológicos e ensaios clínicos
(2019-08-07) Nunes, Ana Clara de França; Piuvezam, Grasiela; ; ; Lais, Lucia Leite; ; Monteiro, Sandra Maria Nunes;
Introdução: A esclerose múltipla (EM) é o distúrbio autoimune mais prevalente na atualidade e está associado à desmielinização dos neurônios no sistema nervoso central por meio da ativação do sistema imunológico. Estudos utilizando a vitamina A vêm se mostrando promissores na melhora da doença. Dessa forma, a presente dissertação tem como objetivo fornecer as melhores evidências disponíveis sobre o impacto clínico da vitamina A nos desfechos relacionados aos sintomas de pacientes portadores de EM. Métodos: Foi utilizado o formato de coletânea de artigos para a produção de dois artigos, sendo o primeiro um artigo de protocolo de revisão sistemática, usado como subsídio para a produção do segundo artigo, a revisão sistemática. Foram realizadas buscas no Pubmed, Embase, Scopus, Cinahl, Scielo, Web of science, Biblioteca cochrane e Science direct, de estudos que avaliassem a relação da suplementação de vitamina A e/ou concentrações séricas e os sintomas em pacientes portadores de EM. Para o delineamento da revisão sistemática foi utilizado o protocolo PRISMA. Para avaliar a qualidade metodológica dos estudos foi utilizada a escala JADAD para os ensaios clínicos randomizados e a Newcastle–Ottawa para os estudos observacionais. Para a extração de todos os dados encontrados foi criado um banco de dados no programa Microsoft Excel. Resultados: Na busca inicial encontramos 2053 estudos, e ao final das buscas foram selecionados 6 artigos elegíveis à pesquisa, sendo 2 Ensaios Clínicos Randomizados e 4 coortes. Dos seis estudos incluídos, dois utilizaram a suplementação de vitamina A e verificaram que a vitamina A é capaz de conter a progressão da doença nos membros superiores e as deficiências cognitivas, além de melhorar significativamente os escores de depressão, fadiga total e as três subescalas de fadiga (física, cognitiva e psicossocial). Os outros quatro estudos realizaram as dosagens das concentrações séricas da vitamina A e constataram que os níveis séricos de retinol não foram associados ao risco ou ao número de recidivas, nem ao agravamento da Escala de status Status de incapacidade Incapacidade expandida Expandida de Kurtzke. Porém, concentrações séricas elevadas de retinol foram associadas a menor da atividade da doença e foram capazes de predizer resultados de novas lesões por meio da ressonância magnética. Conclusão: as evidências identificadas no presente estudo permitem recomendar a suplementação de vitamina A como uma alternativa complementar ao tratamento da EM. Porém, novos ensaios clínicos controlados e bem realizados se fazem necessários para uma melhor definição da dosagem segura.
What are the mechanisms of action of anti-inflammatory agents in adipose tissue? a protocol for systematic review and meta-analysis
(Medicine, 2021) Morais, Ana Heloneida de Araujo; Nascimento, Sara Sayonara da Cruz; Queiroz, Jaluza Luana Carvalho de; Medeiros, Amanda Fernandes de; Nunes, Ana Clara de França; Piuvezam, Grasiela; Maciel, Bruna Leal Lima; Passos, Thaís Souza; https://orcid.org/0000-0002-6460-911X
Background: Obesity is a disease characterized by the abnormal accumulation of adipose tissue in the body, triggering a chronic subclinical state of inflammation. Bioactive compounds, given their anti-inflammatory properties, are a safe and promising alternative in controlling the inflammatory condition of obesity. This study describes a systematic review protocol aiming to analyze the anti inflammatory molecules mechanisms and compounds action on adipocytes. Methods: Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) will outline the protocol and PRISMA to the systematic review. The databases used for research will be PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. Experimental studies performed on rats and mice with a control group that describes treatment with anti-inflammatory agents (drugs, nutraceuticals, bio active compounds, among others) at any frequency, time, and dose will be included. Three independent reviewers will select studies and extract data. The evaluation of the methodological quality of each research will be performed using the SYRCLE tool. If at least 2 studies show clinical and/or methodological and/or statistical homogeneity, a meta analysis will be performed, using the RevMan Analyzes statistical package in Review Manager v.5.3. Results: In this study, we hope to find a considerable number of articles presenting mechanisms involved in the action of anti inflammatory molecules and compounds on adipocytes. Conclusion: The systematic review produced from this protocol will present evidence on the mechanisms involved in the action of anti-inflammatory molecules and compounds in adipocytes. It will also contribute to developing new research and new insights about anti-inflammatory therapies with a future application view. Record of systematic review: This review was registered with the International Register of Prospective Systematic Reviews on May 18, 2020 (registration: CRD42020182897). Available at: https://www.crd.york.ac.uk/prospero/display_record.php?ID= CRD42020182897. Abbreviations: 5-LOX = enzyme 5-lipoxygenase, AMPK = AMP-activated protein kinase, BAT = brown adipose tissue, CAPES = Coordination of Improvement of Higher Education Personnel, CNPq = National Council for Scientific and Technological Development, COX-2 = enzyme cyclooxygenase, IL-6 = Interleukin-6, iNOS = nitric oxide-synthase induced, NF-kB = factor kappa B, Nrf2 = nuclear factor erythroid 2-related factor 2, PICOS = population, interventions, control, and study results, PPAR-g = peroxisome proliferator-activated receptor gamma, PRISMA = Preferred Reporting Items for Systematic Reviews and Meta Analyses, PRISMA-P = Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols, PROSPERO = International Prospective Register of Systematic Reviews, SREBP-1c = sterol regulatory element-binding protein 1, Syrcle = Systematic Review Center for Laboratory Animal Experimentation, TLR = Toll-like receptors, TNF-a = Tumor Necrosis Factor alpha, WAT = white adipose tissue, WHO = World Health Organization.

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Navegando por Autor "Nunes, Ana Clara de França"