Navegando por Autor "Noremberg, Bruno S."
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Artigo Antimicrobial activity from polymeric composites-based polydimethylsiloxane/TiO2/GO: evaluation of filler synthesis and surface morphology(Springer, 2016-11-04) Correa, Camila F.; Santana, Luiza R.; Silva, Ricardo M.; Noremberg, Bruno S.; Lund, Rafael G.; Ribeiro, Juliana S.; Motta, Fabiana Villela da; Delmonte, Maurício Roberto Bomio; Nascimento, Rubens Maribondo do; Carreño, Neftalí Lênin VillarrealAntimicrobial substances may be used to reduce hospital infections and inhibit food contamination, thus ensuring the safety and well being of humans. The objective of this study was to evaluate the antimicrobial activity of the polymeric nanocomposites polydimethylsiloxane (PDMS) embedded with two types of fillers based on titanium dioxide (commercial TiO2 P25 versus TiO2 via facile Micro- wave-assisted hydrothermal-MAH synthesis) and graphene oxide (GO). The nanocomposites were prepared using different compositions, concentrations, and functionalizations (PDMS/TiO2/GO; PDMS/TiO2 and PDMS/GO). The antimicro- bial activity of the samples was evaluated for different treatments on Candida albicans, Staphylococcus aureus, and Enterococcus faecalis, by a modified direct contact test (mDCT). The samples were also evaluated on surface morphology and the roughness as a function of active particles insertion by atomic force microscopy (AFM). Most of the PDMS films whose polymer was embedded with GO and hydrothermal TiO2 showed the highest inhibition growth of bacteria and Candida over 24 h. After 24 h, F, J, and H samples showed the best antibacterial activity, whereas E showed the best antifungal activity. The results indicated that the nanocomposites PDMS/GO/TiO2MAH and PDMS/GO sample enhanced antimi- crobial activity in the treatments tested, therefore they were functional for con- taminant reductionArtigo Preparation, characterization, and biocompatibility of different metal oxide/PEG-based hybrid coating synthesized by sol–gel dip coating method for surface modification of titanium(Elsevier, 2019) Alcázara, José Carlos Bernedo; Lemos, Rafaela Moreira Javier; Conde, Marcus Cristian Muniz; Chisinia, Luiz Alexandre; Salas, Mabel Miluska Suca; Noremberg, Bruno S.; Motta, Fabiana Villela da; Demarco, Flávio Fernando; Tarquinio, Sandra Beatriz Chaves; Carreño, Neftali Lenin VillarrealThe aim of the study was to synthesized organic-inorganic experimental nanocomposite materials via sol–gel dip coating and to characterized its biological response. The sols consist of an inorganic–organic matrix based on ZrO2, TiO2, Li+ and polyethylene glycol (PEG). The obtained hybrid-coated titanium samples have been characterized using atomic force microscope (AFM), Scanning Electronic Microscope (SEM), Energy Dispersive X-Ray Analysis (EDX). Biocompatibility of the hybrid coatings was evaluated by cytotoxicity tests. AFM analysis detailed that the obtained materials were rough nanostructured hybrids. SEM results presented covered surfaces and the presence of particles with different sizes and formats. The EDX data allowed to know the quantitative percentage of the elements present on the surface of the hybrid-coated titanium samples compatible with the sols composition. Cytotoxicity showed that all the hybrid-coated titanium samples had non-cytotoxic effect on target cells, having the groups that included Li+ in the surface higher cellular grown. The sol gel dipcoating method represents a viable alternative to include inorganic and organic elements on titanium and form stable hybrid layers. The modified surfaces of titanium with the experimental materials were rough, presented biocompatible elements and allowed high cellular grown.