Navegando por Autor "Matos, Felipe Rodrigues de"
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Artigo Adenomatoid odontogenic tumor: retrospective study of 15 cases with emphasis on histopathologic features(2012) Matos, Felipe Rodrigues de; Nonaka, Cassiano Francisco Weege; Pinto, Leão Pereira; Souza, Lelia Batista de; Freitas, Roseana de AlmeidaAdenomatoid odontogenic tumor (AOT) is an uncommon benign epithelial lesion of odontogenic origin and, thus far, only few studies regarding the frequency of its many histopathologic features have been published in the literature. Thus, the aim of this study was to perform a retrospective analysis in a case series of AOT, with emphasis on the histopathological features. Fifteen cases of AOT were studied considering their clinical, radiographic and histopathologic aspects. Twelve cases affected females and the mean age was 16.2 years. The anterior maxilla was the most common site (66.6 %) and radiographically most cases showed a unilocular radiolucency with well-defined borders (57.1 %). Histologically, most cases exhibited predominantly a solid growth pattern (46.7 %) or a similar proportion of solid and cribriform patterns (46.7 %). Eosinophilic amorphous material ("tumor droplets") was found in all cases (100 %). Most tumors showed duct-like spaces (93.3 %) and convoluted structures (60.0 %) whereas a minor proportion of cases presented calcifying epithelial odontogenic tumor (CEOT)-like areas (26.7 %). Variable amounts of calcified material were found in most AOTs (80.0 %) whereas osteodentin and perivascular hyalinization were seen only rarely (6.7 % each one). Five (33.3 %) cases had areas mimicking a dentigerous cyst and most of these were diagnosed in females (80.0 %). Regarding the histopathologic features, our results suggest that AOTs usually show predominance of solid pattern or a similar proportion of solid and cribriform patterns while osteodentin and perivascular hyalinization are rarely seen in these tumors. In addition, areas mimicking a dentigerous cyst and CEOT-like areas are relatively infrequent findings in AOTs.Artigo Analysis of inflammatory infiltrate, perineural invasion, and risk score can indicate concurrent metastasis in squamous cell carcinoma of the tongue(2012) Matos, Felipe Rodrigues de; Lima, Emeline das Neves de Araújo; Queiroz, Lelia Maria Guedes; Silveira, Ericka Janine Dantas daPurpose: In this retrospective study, the aim was to compare individual histopathologic parameters of malignancy between nonmetastatic and metastatic squamous cell carcinoma of the tongue. Materials and Methods: Sixty-two cases of squamous cell carcinoma of the tongue were selected and examined according to the system established by Brandwein-Gensler et al (Am J Surg Pathol 29:167, 2005) and included the pattern of invasion (most to least favorable), lymphocytic infiltration, perineural invasion, risk score, keratinization, eosinophilia, perivascular invasion, and tumor thickness. Results: The least favorable pattern had no association with nodal metastasis (P .05). The scarcity or density of the lymphocytic infiltration, perineural invasion, and a risk score 3 were associated with nodal metastasis (P .05). Keratinization, eosinophilia, perivascular invasion, and tumor thickness had no association with nodal metastasis (P .05). A significant positive correlation was found between the pattern of invasion and perineural invasion and between the pattern of invasion and tumor thickness (P .05). Conclusions: The scarcity or density of the lymphocytic infiltration, perineural invasion, and histopathologic risk score may be helpful as parameters of histologic malignancy for the evaluation of metastatic and nonmetastatic squamous cell carcinoma of the tongue.Artigo Epithelial-myoepithelial carcinoma in the ventral surface of the tongue(2010) Matos, Felipe Rodrigues de; Miranda, João Luiz de; Mesquita, Ana Teresinha Marques; Santos, Cássia Roberto Rocha; Freitas, Roseana de AlmeidaMyoepithelial-epithelial carcinoma (MEC) is a low malignancy grade neoplasia which has a prevalence of 1% to 2% among all primary tumors of the salivary gland1. It has a higher incidence at 60 years of age. About 60% of the patients are females. The parotid gland is the most often reported anatomical site; nonetheless, other sites have been reported, such as the submandibular gland, minor salivary glands, paranasal sinus, trachea, lacrymal gland and nasal cavity. Rare are the instances in which this tumor involves the tongue1. Clinically speaking, the well outlined swelling is the only signal, associated or not with pain. Microscopic findings reveal a solid tubular growth which is usually made up of a group of internal epithelial cells with eosinophylic cytoplasm and another group of external myoepithelial cells (MC) with clear cytoplasm.Artigo Expressão de MMPs, marcadores angiogênicos e proliferação celular em tumores odontogênicos(2012) Matos, Felipe Rodrigues de; Vasconcelos, Rodrigo Gadelha; Queiroz, Lelia Maria Guedes; Freitas, Roseana de AlmeidaINTRODUÇÃO E OBJETIVO: O conhecimento do comportamento biológico de lesões de natureza odontogênica é essencial para tornar a abordagem terapêutica adequada e estabelecer um prognóstico. A produção de metaloproteinases da matriz extracelular (MMPs), a angiogênese e a proliferação celular fornecem subsídios para o crescimento tumoral. O presente artigo tem como objetivo fazer uma revisão de literatura de pesquisas em tumores odontogênicos (TOs) selecionados a partir da nova classificação da Organização Mundial da Saúde (OMS) de 2005 sobre a expressão de MMPs, marcadores angiogênicos e proliferação celular e verificar, nestes estudos, a relação desses marcadores quanto ao comportamento biológico dessas lesões. RESULTADOS: Nota-se que as MMPs -1, -2, -7, -9 e -26 encontram-se mais expressas no componente epitelial e estroma e, particularmente, a -13 em estroma. Uma maior angiogênese é observada em TOs mais agressivos. CD 105 foi mais expresso no TO ceratocístico (TOC) e CD34 em ameloblastomas sólidos (ASs). Relata-se elevada expressão do Ki-67 e p53 no TOC e no AS e baixo índice de proliferação celular no TO adenomatoide (TOA). CONCLUSÃO: Esses resultados mostram que as MMPs participam no processo de invasão e recorrência de algumas lesões odontogênicas, estando associadas ao comportamento biológico desses tumores. A angiogênese é fundamental para fornecer suporte à proliferação celular e esses dois eventos em conjunto estão correlacionados com diferentes níveis de comportamento biológico nos TOs, quando comparados com cistos de natureza odontogênica, o que pode sugerir o uso de inibidores angiogênicos como provável abordagem terapêutica nessas lesões.Artigo Immunoexpression of transforming growth factor beta and interferon gamma in radicular and dentigerous cysts(Elsevier, 2014-09) Moraes, Maiara de; Rocha-Neto, Pedro Carlos da; Matos, Felipe Rodrigues de; Lopes, Maria Luiza Diniz de Sousa; Azevedo, Paulo Roberto Medeiros de; Costa, Antonio de Lisboa LopesIntroduction: The aim of this study was to evaluate and compare the immunohistochemical expression of transforming growing factor beta (TGF-b) and interferon gamma (IFN-g) between radicular cysts (RCs) and dentigerous cysts (DCs). Methods: Twenty RCs and DCs were selected for analysis of the immunoexpression of TGF-b and IFN-g in the epithelium and capsule. Results: The cell reactivity of TGF-b and IFN-g in the lining epithelium and capsule of RCs showed no significant differences when compared with DCs (P > .05). There was a tendency of a higher expression of TGF-b in the capsule of DCs. Conclusions: Our results showed the presence of TGF-b and IFN-g in RCs and DCs, supporting the hypothesis that both participate in the development of these lesions, where IFN-g usually plays a role in bone resorption, which is counterbalanced by the osteoprotective activity performed by TGF-b.Artigo Immunohistochemical Detection of Receptor Activator Nuclear κB Ligand and Osteoprotegerin in Odontogenic Cysts and Tumors(2013) Matos, Felipe Rodrigues de; Moraes, Maiara de; Silva, Emília Beatriz das Neves; Galvão, Hebel Cavalcanti; Freitas, Roseana de AlmeidaPurpose The aim of the present study was to compare the immunohistochemical detection of receptor activator nuclear κB ligand (RANKL) and osteoprotegerin (OPG) in radicular cysts (RCs), dentigerous cysts (DCs), solid ameloblastomas (SAs), and keratocystic odontogenic tumors (KOTs). Materials and Methods A total of 20 RCs, 20 DCs, 20 KOTs, 14 dental follicles (DFs), and 18 SAs were evaluated by immunohistochemistry using anti-RANKL and anti-OPG antibodies. The analysis was quantitative, and the number of positive cells was counted in 10 microscopic high-power fields (400×). Results The DFs, KOTs, and SAs showed higher expression of RANKL than did the RCs and DCs in the epithelium (P < .05). The epithelial expression of OPG was higher in the DFs, KOTs, RCs, and DCs than in the SAs (P < .05). The ratio of OPG less than RANKL was more frequent in SAs and OPG greater than RANKL in DCs (P < .05). Conclusions Our results have shown differences in RANKL and OPG detection in the odontogenic cysts and tumors studied. The higher RANKL and lower OPG detection in SA could play a role in bone resorption, compatible with the tumor's biologic behavior.Artigo Nonodontogenic cysts of the oral and maxillofacial region - demographic profile in a Brazilian population over a 40-year period(2011) Nonaka, Cassiano Francisco Weege; Henriques, Águida Cristina Gomes; Matos, Felipe Rodrigues de; Souza, Lélia Batista de; Pinto, Leão PereiraThe aim of the study was to determine the distribution of histologically diagnosed nonodontogenic cysts (nOCs) over a 40-year period in a Brazilian population. Biopsy records from patients with nOC from the files of the Oral Pathology Service during the period of 1970–2009 were evaluated. Among 10,311 oral biopsies, 58 met the criteria of nOCs. The most frequent nOCs were nasopalatine duct cysts (32.8%), followed by epidermoid cysts (20.7%) and oral lymphoepithelial cysts (17.2%). Nasopalatine duct cysts showed predominance among females (68.4%). Epidermoid cysts were most commonly found in the floor of the mouth (36.4%), tongue (27.3%), and buccal mucosa (27.3%). Oral lymphoepithelial cysts exhibited female prevalence (80.0%) and were commonly located in the tongue (44.4%). The frequency of nOCs found in the population studied here is slightly different from those reported in other case series. Nasopalatine duct cysts, epidermoid cysts, and oral lymphoepithelial cysts were the most common nOCs found, accounting for 70.7% of all nOCs.Artigo Oral lichen planus: two case reports in male patients(2010) Moraes, Maiara de; Matos, Felipe Rodrigues de; Pereira, Joabe dos Santos; Medeiros, Ana Miryam Costa de; Silveira, Ericka Janine Dantas daPURPOSE: Lichen planus is a chronic systemic disease that commonly involves the mucosa of the oral cavity, most often in the absence of skin lesions. Although relatively frequent, oral lichen planus is the target of much controversy, mainly in relation to its pathogenesis and possible potential for malignancy. Thus, the objective of this paper is to report two cases of lichen planus in male patients and to discuss the main aspects of this disease in relation to etiopathogenesis and treatment. CASE DESCRIPTION: Physical and histopathological examinations were carried out to confirm the diagnosis of oral lichen planus. An elixir of dexamethasone was prescribed in the first case, and in the second case, topical 0.05% clobetasol propionate was prescribed. After fifteen days, both patients presented regression of the lesion. CONCLUSION: Although the occurrence of oral lichen planus is common, an accurate diagnosis is necessary so that the correct treatment can be established.Tese Valor prognóstico dos polimorfismos funcionais nos genes da mmp-1, mmp-13 e IL-8 no carcinoma epidermóide oral e de orofaringe(UNIVERSIDADE FEDERAL RIO GRANDE DO NORTE, 2013-06-26) Matos, Felipe Rodrigues de; Freitas, Roseana de Almeida; ; http://lattes.cnpq.br/9512014003639405; ; http://lattes.cnpq.br/6755254213132873; Nonaka, Cassiano Francisco Weege; ; http://lattes.cnpq.br/0224522010734716; Silveira, Ericka Janine Dantas da; ; http://lattes.cnpq.br/2186658404241838; Santos, Jean Nunes dos; ; http://lattes.cnpq.br/0926138204356872; Souza, Lelia Batista de; ; http://lattes.cnpq.br/6671914892609743Tumores malignos tem a habilidade de invadir tecidos normais e de se espalharem para sítios anatômicos distantes, originando, a metástase o maior fator de mortalidade do câncer. As metaloproteinases de matriz (MMP)-1 e MMP-13 tem sido associada a invasão tumoral e a metástase, pois a MMP-1 degrada colágeno tipo I, que é o substrato mais abundante no estroma tumoral e a MMP-13 degrada coágeno tipo IV, dentre outros , que está presente na membrana basal dos vasos. Pesquisas mostram que a IL-8 é um potente fator angiogênico e está associada ao crescimento tumoral, à metástase e ao pobre prognóstico do câncer. O presente trabalho se propõe a verificar a existência e a frequências dos polimorfismos nos genes das MMPs-1(rs2071230 e rs470558), -13(rs2252070) e da IL-8 (rs4073 e rs2227532) e investigar o possivel valor prognósticos dos mesmo em uma serie de casos de carcinoma epidermoide oral e de orofaringe(CEOO). Foram genotipados por meio de PCR em tempo real 98 amostra de pacientes com carcinoma epidermóide e 134 amostras controle.