Navegando por Autor "Lima, Adrielle Kétcia Alves de"
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TCC Fenômeno do amanhecer em pacientes com diabetes: uma revisão integrativa(Universidade Federal do Rio Grande do Norte, 2023-09-29) Pamplona, Thalita Thauany de Araújo; Araújo, Ivonete Batista de; http://lattes.cnpq.br/3872552451523411; http://lattes.cnpq.br/9674405211804348; Bezerra, Arthur Silva; http://lattes.cnpq.br/4030326154638784; Lima, Adrielle Kétcia Alves de; http://lattes.cnpq.br/0821150273417717Introdução: O “fenômeno do amanhecer” refere-se a episódios periódicos de hiperglicemia que ocorrem nas primeiras horas da manhã. Pode ser conceituado como uma hiperglicemia de jejum sem antes haver uma hipoglicemia; Objetivo: Compilar na literatura relatos sobre o manejo de pacientes com o fenômeno do amanhecer. Metodologia: Revisão integrativa realizada no período de março a agosto de 2023 com estudos publicados nos últimos 5 anos nas principais bases de dados PubMed/MEDLINE, ScienceDirec e Elsevier, em idioma inglês. Resultados: A busca nos bancos de dados resultou em um total de 4.245 artigos publicados, sendo selecionados apenas 9 para compor a revisão, conforme os critérios de elegibilidade. Conclusão: É preciso estudos prospectivos para conseguir concluir qual a melhor forma de tratamento para os pacientes que têm o fenômeno do amanhecer presente, pois devido os estudos terem muitas limitações é difícil concluir qual é a melhor forma para tratamento, entretanto é importante que ocorra o controle do fenômeno, assim será um grande passo para obter o controle geral da glicemia.TCC Increased nephrin in urinary extracellular vesicles of pregnant women with severe preeclampsia(Universidade Federal do Rio Grande do Norte, 2020-07-20) Lima, Adrielle Kétcia Alves de; Ururahy, Marcela Abbott Galvão; Ururahy, Marcela Abbott Galvão; Souza, Karla Simone Costa de; Domingos, Igor de FariasBackground: Preeclampsia is a systemic syndrome that affects pregnancy, characterized by increased blood pressure and, frequently, proteinuria. It is considered one of the main causes of maternal mortality and due to its possible serious complications, a predictive diagnostic tool is required. There has been increasing evidence that podocytes are related to kidney damage associated to preeclampsia and that the presence of podocyturia was found to be highly sensitive and specific to this disease. Objective: To characterize the expression profile of the podocyte proteins nephrin, podocin and Wilms’ tumor 1 (WT-1) present in the urinary extracellular vesicles of pregnant women diagnosed with severe preeclampsia in order to investigate their potential use as biomarkers in the early diagnosis of the disease. Study Design: This is a cross-sectional study, including 20 pregnant women divided into two groups. The first group with 10 pregnant women diagnosed with severe preeclampsia (case group - PE) and the second, with 10 normotensive pregnant women (control group - CG). Fasting blood samples were used to evaluate the patients' overall metabolic status. First morning urine samples were collected to determinate the albumin/creatinine ratio and to isolate urinary extracellular vesicles by ultracentrifugation. Nephrin, podocin and WT-1 expressions were evaluated by Western-blot. Results: Increased serum creatinine (p = 0.015), uric acid (p <0.001) and urinary albumin/creatinine ratio (p <0.001), as well as decreased serum albumin (p <0.001), total protein (p = 0.037) and calcium (p = 0.003) were found in case group when compared control group. Regarding the podocyte proteins in the urinary extracellular vesicles, significant increased nephrin/creatinine ratio (p = 0.008) was observed in preeclampsia when compared to those from normotensive pregnant women. In addition, the area under de Receiver Operating Characteristic Curve (AUROC) analysis showed that nephrin/creatinine ratio is a good predictor of albuminuria (AUROC = 0.833; p = 0.018). Conclusion: Increase of the nephrin in the urinary extracellular vesicles in pregnant women with preeclampsia proves to be a potential predictor for the early diagnosis of the disease.