Navegando por Autor "Lemos, Telma Maria de Araújo Moura"
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Artigo Carbohydrate mouth rinse and hydration strategies on cycling performance in 30 km time trial: a randomized, crossover, controlled trial(Journal of Sports Science and Medicine, 2018-05) Fayh, Ana Paula Trussardi; Ferreira, Amanda Maria de Jesus; Farias Junior, Luiz Fernando; Mota, Thaynan Aline de Araújo; Elsangedy, Hassan Mohamed; Oliveira, Aline Marcadenti; Lemos, Telma Maria de Araújo Moura; Okano, Alexandre HidekiThe aim of this study was to investigate whether carbohydrate mouth rinse (CMR) improves physical performance of cyclists during a 30-km time trial test and its influence on water balance compared to other strategies of fluid intake. Eleven recreationally trained male cyclists completed a 30 km time trial cycle ergometer under three experimental interventions: (a) CMR, (b) drinking to replace all weight loss (DWL), and (c) drinking “ad libitum” (DAL). Time to complete the 30 km time trial, heart rate, average power, velocity, weight loss, urine color, urine density and pH were evaluated. Statistical analysis was performed using repeated measures analysis of variance (RM-ANOVA) and generalized estimating equations (GEE) with Bonferroni adjustment (p < 0.05). Time to complete the 30 km time trial was similar among CMR 54.5 ± 2.9 min, DWL 53.6 ± 3.9 min and DAL 54.5 ± 2.5 min (p = 0.13). CMR (1.7 ± 0.4%) elicited similar water loss compared to the DAL (1.4 ± 0.6%) intervention, but it was higher than the DWL intervention (0.6 ± 0.6%) (p < 0.01). CMR did not improve the performance of recreationally trained cyclists in a 30 km time trial test compared to other fluid intake strategies. Furthermore, CMR causes higher water loss compared to DWL interventionArtigo Induction chemotherapy reduces extracellular heat shock protein 72 levels, inflammation, lipoperoxidation and changes insulin sensitivity in children and adolescents newly diagnosed with acute lymphoblastic leukemia(Oncotarget, 2018-06) Fayh, Ana Paula Trussardi; Gomes, Camila de Carvalho; Schroeder, Helena Trevisan; Muller, Carlos Henrique de Lemos; Lemos, Telma Maria de Araújo Moura; Krause, MauricioBackground: Acute lymphoblastic leukemia (ALL) is associated with higher levels of pro-inflammatory cytokines and oxidative stress. Recently, the levels of extracellular heat shock protein 72 (eHSP72) were found to be elevated in ALL, and its elevation associated with poor prognosis. Therefore, considering the possible role of eHSP72 as a modulator of the immunological system and metabolism, the aim of this study was to describe the response of eHSP72 to the induction phase of chemotherapy, along with metabolic, inflammatory and oxidative stress markers, in children and adolescents newly diagnosed with ALL. Methods: Nineteen patients were recruited and analysed before and after the induction phase of chemotherapy (with 28 days of duration). Blood samples were taken for the analysis of C-reactive protein (CRP), levels of lipoperoxidation, insulin (and HOMA-IR), cortisol, glucose, lipid profile and eHSP72. Results: We found that induction phase of chemotherapy leads to a drop in glucose levels (from 101.79±19 to 75.8±9.7 mg/dL), improvements on inflammation (CRP levels, p<0.01) and oxidative stress (TBARS levels, p<0.01), reduction on eHSP72 (p=0.03) and improved insulin sensitivity (HOMA-IR, p=0.02). Conclusion: Our results indicate that eHSP72 may have an immune and metabolic role and could be used as a marker of the treatment success and metabolic changes in children with ALLArtigo Nutritional status and appetite-regulating hormones in early treatment of acute lymphoblastic leukemia among children and adolescents: a cohort study(Sao Paulo Medical Journal, 2020) Fayh, Ana Paula Trussardi; Gomes, Camila de Carvalho; Silva, Cassia Camila Gomes da; Nascimento, Paulo Ricardo Porfírio do; Lemos, Telma Maria de Araújo Moura; Marcadenti, Aline; Markoski, Melissa MedeirosBACKGROUND: Children with acute lymphoblastic leukemia are at risk of malnutrition, but few studies have described the changes in nutritional status during the different phases of chemotherapy. OBJECTIVE: To evaluate changes in nutritional status, food intake and appetite-regulating hormones among children and adolescents with acute lymphoblastic leukemia in the first phase of chemotherapy. DESIGN AND SETTING: Cohort study developed in the pediatric oncology departments of two hospitals in the city of Natal, Rio Grande do Norte, Brazil. METHODS: Fourteen children/adolescents (mean age of 7 years; 50% female) with acute lymphoblastic leukemia were monitored over the 28 days of an induction chemotherapy cycle. Anthropometric measurements, 24-hours food weight records and appetite-regulating hormone levels (ghrelin, leptin, insulin and cortisol) were obtained at three different times (before, in the middle and at the end of the induction phase). RESULTS: Most of the patients (85.7%) had normal weight at the beginning of the treatment, and this did not change significantly during the 28 days. Energy and nutrient intakes improved from the start of the treatment to the midpoint, according to the ghrelin levels (from 511.1 ± 8.3 to 519.3 ± 6.6 pg/ml; P = 0.027). Other appetite-regulating hormones did not present changes. CONCLUSION: Food consumption improves during the first phase of treatment, without alterations in anthropometric nutritional statusTCC Síndrome dos ovários policísticos: análise de uma década de avanços e perspectivas - uma revisão abrangente da síndrome dos ovários policísticos(Universidade Federal do Rio Grande do Norte, 2023-12-05) Santiago, Cláudia O'ara Azevedo; Lemos, Telma Maria de Araújo Moura; 0000-0001-7118-2145; http://lattes.cnpq.br/4311626091295357; 0000-0001-6368-9288; http://lattes.cnpq.br/0138662594722823; Gouveia, Fabíola Leite; http://lattes.cnpq.br/8781637325653105; Fonseca, Aldilane Gonçalves da; http://lattes.cnpq.br/0311976853459865A SOP é uma prevalente condição endócrina que afeta mulheres, impactando a homeostase metabólica e o sistema cardiovascular. Este estudo revisa os múltiplos critérios diagnósticos, características clínicas, etiologia multifatorial, associações com comorbidades, epidemiologia, história, fisiopatologia, diagnóstico diferencial e perspectivas atuais no tratamento. Utilizando o banco de dados do PubMed, foi realizada uma revisão de periódicos nos últimos 5 anos, excluindo condições endócrinas distintas e garantindo a relevância e atualidade dos artigos incluídos. A SOP apresenta prevalência variada pelos critérios diagnósticos, com histórico documentado desde o século XVIII. A evolução dos critérios diagnósticos reflete a complexidade da síndrome. A perturbação hormonal, RI, fatores epigenéticos e exposição a agentes ambientais contribuem para a complexa fisiopatologia da SOP, influenciando a função ovulatória, morfologia ovariana e desencadeando processos inflamatórios. O diagnóstico envolve uma triagem de exclusão, utilizando exames clínicos, ultrassonografia transvaginal e avaliação hormonal. Critérios internacionais são discutidos, incluindo a consideração do AMH como marcador adicional. Apesar da falta de medicamentos aprovados especificamente para SOP, diferentes abordagens, incluindo estilo de vida, medicamentos e intervenções cirúrgicas, são discutidas. A gestão visa à personalização do tratamento, considerando a perda de peso, medicamentos como AOC e a metformina. A SOP é uma condição desafiadora, requerendo uma abordagem personalizada. A compreensão abrangente dos critérios diagnósticos, fisiopatologia e opções terapêuticas é crucial para a gestão clínica eficaz, considerando os impactos a longo prazo na saúde reprodutiva, metabólica e cardiovascular.Artigo The effect of carbohydrate mouth rinse on performance, biochemical and psychophysiological variables during a cycling time trial: a crossover randomized trial(Journal of the International Society of Sports Nutrition, 2018-05) Fayh, Ana Paula Trussardi; Ferreira, Amanda Maria de Jesus; Farias Junior, Luiz Fernando; Mota, Thaynan Aline de Araújo; Elsangedy, Hassan Mohamed; Marcadenti, Aline; Lemos, Telma Maria de Araújo Moura; Okano, Alexandre HidekiBackground: The hypothesis of the central effect of carbohydrate mouth rinse (CMR) on performance improvement in a fed state has not been established, and its psychophysiological responses have not yet been described. The aim of this study was to evaluate the effect of CMR in athletes fed state on performance, biochemical and psychophysiological responses compared to ad libitum water intake. Methods: Eleven trained male cyclists completed a randomized, crossover trial, which consisted of a 30 km cycle ergometer at self-selected intensity and in a fed state. Subjects were under random influence of the following interventions: CMR with a 6% unflavored maltodextrin solution; mouth rinsing with a placebo solution (PMR); drinking “ad libitum” (DAL). The time for completion of the test (min), heart rate (bpm) and power (watts), rating of perceived exertion (RPE), affective response, blood glucose (mg/dL) and lactate (mmol/DL), were evaluated before, during and immediately after the test, while insulin (uIL/mL), cortisol (μg/dL) and creatine kinase (U/L) levels were measured before, immediately after the test and 30 min after the test. Results: Time for completion of the 30 km trial did not differ significantly among CMR, PMR and DAL interventions (means = 54.5 ± 2.9, 54.7 ± 2.9 and 54.5 ± 2.5 min, respectively; p = 0.82). RPE and affective response were higher in DAL intervention (p < 0.01). Glucose, insulin, cortisol and creatine kinase responses showed no significant difference among interventions. Conclusions: In a fed state, CMR has not caused metabolic changes, and it has not improved physical performance compared to ad libitum water intake, but demonstrated a possible central effect. ReBec registration number: RBR4vpwkg. Available in http://www.ensaiosclinicos.gov.br/rg/?q=RBR-4vpwkg