Navegando por Autor "Katche, Cynthia"
Agora exibindo 1 - 4 de 4
- Resultados por página
- Opções de Ordenação
Artigo Functional integrity of the retrosplenial cortex is essential for rapid consolidation and recall of fear memory(2013) Katche, Cynthia; Dorman, Guido; Slipczuk, Leandro; Cammarota, Martín Pablo; Medina, Jorge H.Memory storage is a temporally graded process involving different phases and different structures in the mammalian brain. Cortical plasticity is essential to store stable memories, but little is known regarding its involvement in memory processing. Here we show that fear memory consolidation requires early post-training macromolecular synthesis in the anterior part of the retrosplenial cortex (aRSC), and that reversible pharmacological inactivation of this cortical region impairs recall of recent as well as of remote memories. These results challenge the generally accepted idea that neocortical areas are slow encoding systems that participate in the retrieval of remote memories only.Artigo Medial prefrontal cortex dopamine controls the persistent storage of aversive memories(2014-11-26) Gonzalez, María C.; Kramar, Cecilia P.; Tomaiuolo, Micol; Katche, Cynthia; Weisstaub, Noelia; Cammarota, Martín Pablo; Medina, Jorge H.Artigo Molecular signatures and mechanisms of long-lasting memory consolidation and storage(2013) Katche, Cynthia; Cammarota, Martín Pablo; Medina, Jorge H.A body of evidence emerged in the last decade regarding late posttraining memory processing. Most of this new information comes from aversively motivated learning tasks that mainly depend on hippocampus, amygdala and insular cortex, and points to the involvement of long-lasting changes in gene expression and protein synthesis in late stages of memory consolidation and storage. Here, we describe recent advances in this field and discuss how recurrent rounds of macromolecular synthesis and its regulation might impact long-term memory storage.Artigo On the Role of Retrosplenial Cortex in Long-Lasting Memory Storage(2013) Katche, Cynthia; Dorman, Guido; Gonzalez, Carolina; Kramar, Cecilia P.; Slipczuk, Leandro; Rossato, Janine I.; Cammarota, Martín Pablo; Medina, Jorge H.The retrosplenial cortex (RSC) is involved in a range of cognitive functions. However, its precise involvement in memory processing is unknown. Pharmacological and behavioral experiments demonstrate that protein synthesis and c-Fos expression in the anterior part of RSC (aRSC) are necessary late after training to maintain for many days a fear-motivated memory. Long-lasting memory storage is regulated by D1/ D5 dopamine receptors in aRSC and depends on the functional interplay between dorsal hippocampus and aRSC. These results suggest that the RSC recapitulates some of the molecular events that occur in the hippocampus to maintain memory trace over time.