Navegando por Autor "Henriques, Águida Cristina Gomes"
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Artigo Aggressive olfactory neuroblastoma invading the oral cavity: report of a rare case and review of the literature(ELSEVIER, 2012) Sarmento, Dmitry José de Santana; Henriques, Águida Cristina Gomes; Carvalho, Cyntia Helena Pereira de; Morais, Maria de Lourdes Silva Arruda de; Costa, Antonio de Lisboa Lopes; Silveira, Ericka Janine Dantas daEsthesioneuroblastoma, or olfactory neuroblastoma (ONB), is a rare malignant tumor of the olfactory neuroepithelium, which is normally confined to the superior one third of the nasal septum, cribriform plate, and superior turbinates but may extend to the base of the skull and intracranial space. ONB accounts for only 3% of all intranasal tumors, and its etiology remains unclear. The tumor can affect both children and adults, with a bimodal peak incidence between 11 and 20 years and between 51 and 60 years.1 Controversy exists regarding the origin, diagnosis, and management of ONB, mainly because of its rarity and the fact that most institutions treat only a small number of patients with this diagnosis.2; 3 ; 4 Many cases go unrecognized because of difficulties in the diagnosis of this tumor as a result of nonspecific initial symptoms (nasal obstruction, recurrent epistaxis). There are rare reports of ONB arising in the nasopharynx, ethmoid sinus, and maxillary sinus. We report a rare case of a very large ONB in a pediatric patient. The clinical appearance of the tumor and diagnostic procedure are discussed, and cases published in the literature are reviewed.Artigo Clinical pathological analysis of nine cases of aneurysmal bone cyst of the jaws in a Brazilian population(2012) Henriques, Águida Cristina Gomes; Carvalho, Marianne de Vasconcelos; Miguel, Marcia Cristina da Costa; Queiroz, Lelia Maria Guedes; Silveira, Ericka Janine Dantas daAneurysmal bone cysts (ABCs) are benign osteolytic lesions that occur rarely in the jaws. The aim of this study was to investigate the clinical, radiographical and pathological features of ABCs of the jaws. A retrospective analysis of the content of a 39-year database, including nine cases of ABCs of the jaws diagnosed from the archives of the Oral Pathology Service. Nine patients (3 males and 6 females), ranging in age from 5 to 33 years were included. Seven (7/9) lesions were located in the mandible and two (2/9) in the maxilla. A painful swelling was the most common clinical finding (n = 4, 4/9). Radiologically, the lesions frequently presented as multilocular (5/9), well defined (4/9), bone expansion and perforation (2/9). Pathological analysis revealed that two cases were associated with central ossifying fibroma and one case with central giant cell lesion. Histomorphology showed a predominance of the solid type (5/9) and of sinusoidal pseudocystic spaces (4/9). Giant cells, osteoid material, calcified material, blood vessels and hemosiderin deposits were observed in 6/9, 7/9, 8/9, 9/9 and 7/9, respectively. The patients with ABCs presented clinical and radiographical features, which often posed a diagnostic dilemma. Knowledge about the most common characteristics of ABCs may contribute to the establishment of a more accurate diagnosis.Artigo Comparative analysis of the immunohistochemical expression of collagen IV, MMP-9, and TIMP-2 in odontogenic cysts and tumors(2011) Henriques, Águida Cristina Gomes; Vasconcelos, Marcelo Gadella; Galvão, Hebel Cavalcanti; Souza, Lelia Batista de; Freitas, Roseana de AlmeidaObjective. The aim of this study was to evaluate the immunohistochemical expression of collagen IV, matrix metalloproteinase (MMP) 9 and tissue inhibitor of MMP (TIMP) 2 in dentigerous cysts (DCs), radicular cysts (RCs), keratocystic odontogenic tumors (KOTs), and ameloblastomas. Study design. Twenty cases of DCs, 20 RCs, 20 KOTs, and 20 ameloblastomas were selected and analyzed by immunohistochemistry. Results. Most DCs and RCs showed continuous and 50% staining for collagen IV in the basement membrane of the epithelium, whereas predominantly discontinuous thin and 50% staining was observed in KOTs and ameloblastomas, with a significant difference in staining percentage (P .001). MMP-9 was diffusely distributed and localized in both epithelial and mesenchymal cells of all of the lesions analyzed. The staining percentage was higher in the epithelium (P .058) and mesenchyme (P .005) of KOTs and ameloblastomas. Moreover, the distribution pattern, location, and percentage of expression of TIMP-2 were similar in the lesions studied, except for ameloblastoma, with a significant difference in staining percentage (P .001). Conclusion. These results demonstrate that the interaction between collagen IV, MMP-9, and TIMP-2 is an important factor for the establishment of differences in the biologic behavior of the odontogenic cysts and tumors studied.Artigo Epidemiology and correlation of the clinicopathological features in oral epithelial dysplasia: analysis of 173 cases(2011) Pereira, Joabe dos Santos; Carvalho, Marianne de Vasconcelos; Henriques, Águida Cristina Gomes; Camara, Tiago Henrique de Queiroz; Miguel, Marcia Cristina da Costa; Freitas, Roseana de AlmeidaOral epithelial dysplasias (OEDs) are potentially malignant disorders characterized by diverse degrees of cellular atypia. The early and careful diagnosis has extreme importance, allowing prevention of the progression to the oral squamous cell carcinoma. This study aimed to determine the epidemiology and then correlate it with the clinicopathological features of OED. One hundred seventy-three cases of oral lesions retrieved from the files of a Service of Pathological Anatomy, covering a 38-year period, were submitted to descriptive statistical analysis through the Pearson χ(2) test. The majority of cases were from affected females (57.9%), with a peak of occurrence in the age group of 41 and 55 years (37.3%), white patients (64.8%), and those with lesions located on the gingiva/alveolar ridge (25.1%). The lesions predominantly presented with white color (56.8%) and were described as nodules (27.4%), with a rough surface (76.7%), an exophytic growth (79.1%), and a sessile base (95.6%). The majority of the lesions with degree of mild (34.6%) and moderate (34.9%) OED had clinical diagnosis of leukoplakia, whereas 33.3% of the lesions with degree of severe had clinical diagnosis of squamous cell carcinoma (P < .05). Tobacco use was the risk habit more related with OED (42.6%) (P > .05). The knowledge of OED epidemiology and clinical features provide a better understanding of the factors that possibly are associated with the malignant transformation of OED. Furthermore, these results contribute to supporting a prompt and accurate recognition of these lesions in clinical practice.Artigo Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip(2011) Barros, Simone Souza Lobão Veras; Henriques, Águida Cristina Gomes; Pereira, Karuza Maria Alves; Medeiros, Ana Miryam Costa de; Galvão, Hebel Cavalcanti; Freitas, Roseana de AlmeidaObjective To evaluate the immunohistochemical expression of MMP-1, -2, -7, -9 and -26 in oral squamous cell carcinomas (SCCs) according to tumour site and histological grade of malignancy. Study design Fifteen cases of SCC of the lower lip and 15 cases of tongue SCC were selected and divided into low grade malignancy (n = 17) and high grade malignancy (n = 13). Results Higher immunohistochemical expression of MMPs by neoplastic cells was observed in tongue SCCs, with a statistically significant difference for MMP-9 (P < 0.05). High-grade SCCs showed a higher expression of MMPs, except for MMP-2, with a statistically significant difference for MMP-7 (P < 0.05) and MMP-26 (P < 0.05). In addition, a direct association was observed between morphological scores of malignancy and MMP immunoreactivity, with the association being significant for MMP-7 and MMP-26. Conclusion The present results demonstrate the important role of MMPs in the development of SCCs of the lower lip and tongue.Artigo Low-level laser therapy promotes proliferation and invasion of oral squamous cell carcinoma cells(2014) Henriques, Águida Cristina Gomes; Ginani, Fernanda; Oliveira, Ruth Medeiros; Keesen, Tatjana Souza Lima; Barboza, Carlos Augusto Galvão; Rocha, Hugo Alexandre Olivera; Castro, Jurema Freire Lisboa de; Coletta, Ricardo Della; Freitas, Roseana de AlmeidaLow-level laser therapy (LLLT) has been shown to be effective in promoting cell proliferation. There is speculation that the biostimulatory effect of LLLT causes undesirable enhancement of tumor growth in neoplastic diseases since malignant cells are more susceptible to proliferative stimuli. This study evaluated the effects of LLLT on proliferation, invasion, and expression of cyclin D1, E-cadherin, β-catenin, and MMP-9 in a tongue squamous carcinoma cell line (SCC25). Cells were irradiated with a diode laser (660 nm) using two energy densities (0.5 and 1.0 J/cm(2)). The proliferative potential was assessed by cell growth curves and cell cycle analysis, whereas the invasion of cells was evaluated using a Matrigel cell invasion assay. Expression of cyclin D1, E-cadherin, β-catenin, and MMP-9 was analyzed by immunofluorescence and flow cytometry and associated with the biological activities studied. LLLT induced significantly the proliferation of SCC25 cells at 1.0 J/cm(2), which was accomplished by an increase in the expression of cyclin D1 and nuclear β-catenin. At 1.0 J/cm(2), LLLT significantly reduced E-cadherin and induced MMP-9 expression, promoting SCC25 invasion. The results of this study demonstrated that LLLT exerts a stimulatory effect on proliferation and invasion of SCC25 cells, which was associated with alterations on expression of proteins studied.Artigo Nonodontogenic cysts of the oral and maxillofacial region - demographic profile in a Brazilian population over a 40-year period(2011) Nonaka, Cassiano Francisco Weege; Henriques, Águida Cristina Gomes; Matos, Felipe Rodrigues de; Souza, Lélia Batista de; Pinto, Leão PereiraThe aim of the study was to determine the distribution of histologically diagnosed nonodontogenic cysts (nOCs) over a 40-year period in a Brazilian population. Biopsy records from patients with nOC from the files of the Oral Pathology Service during the period of 1970–2009 were evaluated. Among 10,311 oral biopsies, 58 met the criteria of nOCs. The most frequent nOCs were nasopalatine duct cysts (32.8%), followed by epidermoid cysts (20.7%) and oral lymphoepithelial cysts (17.2%). Nasopalatine duct cysts showed predominance among females (68.4%). Epidermoid cysts were most commonly found in the floor of the mouth (36.4%), tongue (27.3%), and buccal mucosa (27.3%). Oral lymphoepithelial cysts exhibited female prevalence (80.0%) and were commonly located in the tongue (44.4%). The frequency of nOCs found in the population studied here is slightly different from those reported in other case series. Nasopalatine duct cysts, epidermoid cysts, and oral lymphoepithelial cysts were the most common nOCs found, accounting for 70.7% of all nOCs.