Navegando por Autor "Godeiro Junior, Clecio de Oliveira"
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Artigo Acute hemicerebellitis in a young adult: a potential pitfall(SciELO, 2021-06-03) Godeiro Junior, Clecio de Oliveira; Moreira Neto, Manuel; Fraiman, Pedro Henrique Almeida; 0000-0002-4312-1633A 20-year-old man presented with a new headache for 21 days. His neurological examination showed mild right-side ataxia while walking in tandem. Brain MRI revealed extensive hyperintensities in the right cerebellar hemisphere in FLAIR/T2WI and moderate choline peak and low NAA.Artigo Late-onset congenital syphilis with unusual brain abnormalities(sciELO, 2017-09) Godeiro Junior, Clecio de Oliveira; 0000-0002-4312-1633A 17-year-old woman presented with ataxia, refractory epilepsy and progressive cognitive decline since the age of eight. A brain MRI showed white matter abnormalities and atrophy.Artigo Rapidly progressive sporadic Creutzfeldt-Jakob disease: isolated Heidenhain variant or a combination with PRES?(SciElo, 2020-09-19) Godeiro Junior, Clecio de Oliveira; Fraiman, Pedro Henrique Almeida; Teixeira, Carolina Militão; Oliveira, Juliano César Dantas de; Sousa, Thadeu Alexandre Paulino de; Moreira Neto, Manuel; 0000-0002-4312-1633A 70-year-old man presented with rapidly progressive cognitive impairment with ataxia and myoclonus. Visual agnosia was noticed after blood pressure oscillations, during immunoglobulin therapy for suspected autoimmune encephalitis.Artigo Variants in SNCA gene are associated with parkinson’s disease risk and cognitive symptoms in a brazilian sample(Frontiers in Aging Neuroscience, 2017-06-20) Godeiro Junior, Clecio de Oliveira; Campêlo, Clarissa Loureiro das Chagas; Cagni, Fernanda Carvalho; Figueredo, Diego de Siqueira; Oliveira Junior, Luiz Gonzaga; Silva Neto, Antônio Braz; Macêdo, Priscila T.; Santos, José R.; Izídio, Geison Souza; Ribeiro, Alessandra Mussi; Andrade, Tiago Gomes de; Silva, Regina Helena; 0000-0002-4312-1633Genetic susceptibility contributes to the etiology of sporadic Parkinson’s Disease (PD) and worldwide studies have found positive associations of polymorphisms in the alphasynuclein gene (SNCA) with the risk for PD. However, little is known about the influence of variants of SNCA in individual traits or phenotypical aspects of PD. Further, there is a lack of studies with Latin-American samples. We evaluated the association between SNCA single nucleotide polymorphisms (single nucleotide polymorphisms, SNPs –rs2583988, rs356219, rs2736990, and rs11931074) and PD risk in a Brazilians sample. In addition, we investigated their potential interactions with environmental factors and specific clinical outcomes (motor and cognitive impairments, depression, and anxiety). A total of 105 PD patients and 101 controls participated in the study. Single locus analysis showed that the risk allele of all SNPs were more frequent in PD patients (p < 0.05), and the associations of SNPs rs2583988, rs356219, and rs2736990 with increased PD risk were confirmed. Further, the G-rs356219 and C-rs2736990 alleles were associated with early onset PD. T-rs2583988, G-rs356219 and C-2736990 alleles were significantly more frequent in PD patients with cognitive impairments than controls in this condition. In addition, in a logistic regression model, we found an association of cognitive impairment with PD, and the practice of cognitive activity and smoking habits had a protective effect. This study shows for the first time an association of SNCA polymorphism and PD in a South-American sample. In addition, we found an interaction between SNP rs356219 and a specific clinical outcome, i.e., the increased risk for cognitive impairment in PD patients.