Navegando por Autor "Galvão-Coelho, Nicole Leite"

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Aspectos gerais do uso da ayahuasca no sistema nervoso central e implicações terapêuticas
(Universidade Federal do Rio Grande do Norte, 2022-02-15) Oliveira, Leonardo Lúcio de; Cavalcante, Jeferson de Souza; 0000-0002-2714-0746; http://lattes.cnpq.br/2378505945149958; 0000-0002-7728-1934; http://lattes.cnpq.br/6142087446783565; Galvão-Coelho, Nicole Leite; 0000-0002-4887-8635; http://lattes.cnpq.br/9256395169042054; Linhares, Sarah Sophia Guedes; http://lattes.cnpq.br/6789859059113085
Ayahuasca, é um termo genérico empregado de origem Quéchua, é uma bebida com propriedades psicoativas, sendo o resultado principal da decocção entre a casca do cipó Banisteriopsis caapi e as folhas de Psychotria viridis. Essa terminologia tem origem indígena, sobretudo comumente utilizada por povos das regiões da Bacia Amazônica, localizada na América do Sul. O uso da Ayahuasca vem sendo amplamente estudado ao redor do mundo, sobretudo do ponto de vista molecular e seus principais efeitos psicodélicos no Sistema Nervoso Central. É bem verdade que, as aplicações clínicas das terapias psicodélicas e neurocomportamentais têm crescido substancialmente em paralelo ao uso de antidepressivos, principalmente por se tratar de uma rota alternativa no combate das desordens de humor, ansiedade, depressão e substâncias químicas. As inúmeras potencialidades das aplicações práticas e terapêuticas do uso dos psicodélicos acendeu uma luz e permitiu a expansão dos estudos por diversos pesquisadores, norteando para um futuro onde os antidepressivos possam ser substituídos por outros métodos de tratamentos menos invasivos, e que não gerem dependência ou desconforto por causa dos efeitos residuais das drogas. O uso do DMT como exposição crônica e intermitente em subdoses alucinógenas, tem se mostrado um caminho promissor, é o que pesquisas recentes têm demonstrado em roedores. Os psicodélicos vêm sendo descritos como potenciais psicoplastogênicos, por serem capazes de induzir a plasticidade neural, bem como a formação de novas árvores dendríticas no Córtex Pré-Frontal. Em suma, a presente revisão considerará possíveis alternativas de administração psicodélica da ayahuasca no estudo de desordens do Sistema Nervoso Central (SNC), bem como as inúmeras potencialidades que a ayahuasca apresenta para a redução da ansiedade e depressão, seja em modelo experimental animal (roedores), primatas não humanos e seres humanos.
Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression
(2020-04-28) Santiago, Giuliana Travassos Pires; Galvão, Ana Cecília de Menezes; Almeida, Raíssa Nóbrega de; Mota-Rolim, Sergio Arthuro; Palhano-Fontes, Fernanda; Maia-de-Oliveira, João Paulo; Araújo, Dráulio Barros de; Lobão-Soares, Bruno; Galvão-Coelho, Nicole Leite
Sleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor (BDNF) levels, which in turn are also changed in major depression. Here, we evaluated the relationship between sleep quality, salivary cortisol awakening response (CAR), and serum BDNF levels in patients with sleep disturbance and treatment-resistant major depression (n = 18), and in a control group of healthy subjects with good (n = 21) and poor (n = 18) sleep quality. We observed that the patients had the lowest CAR and sleep duration of all three groups and a higher latency to sleep than the healthy volunteers with a good sleep profile. Besides, low CAR was correlated with more severe depressive symptoms and worse sleep quality. There was no difference in serum BDNF levels between groups with distinct sleep quality. Taken together, our results showed a relationship between changes in CAR and in sleep quality in patients with treatment-resistant depression, which were correlated with the severity of disease, suggesting that cortisol could be a physiological link between sleep disturbance and major depression.
Common marmosets: a potential translational animal model of juvenile depression
(2017-09-21) Galvão-Coelho, Nicole Leite; Galvão, Ana Cecília de Menezes; Silva, Flávia Santos da; Sousa, Maria Bernardete Cordeiro de
Major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. Frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. Therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. To this end, this study investigated the effects of chronic social isolation and the potential antidepressant action of nortriptyline in juvenile Callithrix jacchus males and females by monitoring fecal cortisol, body weight, and behavioral parameters and searching for biomarkers and a protocol for inducing depression. The purpose was to validate this species and protocol as a translational model of juvenile depression, addressing all domain criteria of validation: etiologic, face, functional, predictive, inter-relational, evolutionary, and population. In both sexes and both protocols (IDS and DPT), we observed a significant reduction in cortisol levels in the last phase of social isolation, concomitant with increases in autogrooming, stereotyped and anxiety behaviors, and the presence of anhedonia. The alterations induced by chronic social isolation are characteristic of the depressive state in non-human primates and/or in humans, and were reversed in large part by treatment with an antidepressant drug (nortriptyline). Therefore, these results indicate C. jacchus as a potential translational model of juvenile depression by addressing all criteria of validation.
Efeito do parceiro social sobre a resposta comportamental ao ambiente novo em sagüi comum (Callithrix jacchus)
(2007) Ribeiro, Raíssa Risoleta Cavalcante; Galvão-Coelho, Nicole Leite; Sousa, Maria Bernardete Cordeiro de
Hormonal correlates of behavioural profiles and coping strategies in captive capuchin monkeys (Sapajus libidinosus)
(2018-10) Ferreira, Vitor Hugo Bessa; Silva, Carolina Pereira Cadório da; Fonseca, Elanne de Paiva; Chagas, Ana Cecilia Correia Santos das; Almeida, Raissa Nobrega de; Sousa, Maria Bernardete Cordeiro de; Silva, Hélderes Peregrino Alves da; Galvão-Coelho, Nicole Leite; Ferreira, Renata Gonçalves
In this study, we tested the hypothesis that individual differences in behavioural profiles correlate to differences in stress-related behaviours and hormonal levels in captive brown capuchin monkeys (Sapajus libidinosus). Based on a sample of 25 animals, 143 h of behavioural data collection and 518 faecal samples, principal component analyses indicated the existence of four components that characterize the individuals´ Genus Normative Behaviour (GNB) (KMO = 0.531, X2 = 127.672, p < 0.001): ‘Feeding’, ‘Sociability’, ‘Exploration’, and ‘Activity’. Other four components are related to stress coping styles (based on Behaviour Potentially Indicative of Stress – BPIS) (KMO = 0.550, X2 = 329.303, p < 0.001): ‘Self-directed’; ‘Restless’, ‘Ingestion/Self-Scratching’, and ‘Stereotyped’. More active individuals exhibit rapid stress-related behaviours (r = 0.443; p = 0.044) while less active individuals exhibit more stationary stress-related behaviours (r = -0.519; p = 0.013). Akaike information criteria indicated that the best linear regression model to predict the physiological profile (Faecal Glucocorticoid Metabolites - FGM) included three GNB and three BPIS components. ‘Sociability’ (p < 0.05), ‘Exploration’ (p < 0.05), and ‘Ingestion/Self-scratching’ (p < 0.05) predicted lower FGM levels. ‘Activity’ (p < 0.05), ‘Self-directed’ (p < 0.05), and ‘Stereotyped’ (p < 0.05) predicted higher FGM levels. ‘Feeding’ and ‘Restless’ factors were not included in the models. Our results support previous studies indicating that animals within the same population differ in the way they behave and react to stressful conditions, and these are correlated to different physiological profiles. Mapping inter-individual differences in stress coping strategies may help clarify the long-term reported incongruity between behavioural and physiological indicators of welfare in captive animals, supporting better management practices and assisting translational models of the development of psychopathologies.
Modulation of serum brain-derived neurotrophic factor by a single dose of Ayahuasca: observation from a randomized controlled trial
(2019-06-04) Almeida, Raíssa Nóbrega de; Galvão, Ana Cecília de Menezes; Silva, Flávia Santos da; Silva, Erick Allan dos Santos; Palhano-Fontes, Fernanda; Maia-de-Oliveira, João Paulo; Araújo, Dráulio Barros de; Lobão-Soares, Bruno; Galvão-Coelho, Nicole Leite
Serotonergic psychedelics are emerging as potential antidepressant therapeutic tools, as suggested in a recent randomized controlled trial with ayahuasca for treatment-resistant depression. Preclinical and clinical studies have suggested that serum brain-derived neurotrophic factor (BDNF) levels increase after treatment with serotoninergic antidepressants, but the exact role of BDNF as a biomarker for diagnostic and treatment of major depression is still poorly understood. Here we investigated serum BDNF levels in healthy controls (N = 45) and patients with treatment-resistant depression (N = 28) before (baseline) and 48 h after (D2) a single dose of ayahuasca or placebo. In our sample, baseline serum BDNF levels did not predict major depression and the clinical characteristics of the patients did not predict their BDNF levels. However, at baseline, serum cortisol was a predictor of serum BDNF levels, where lower levels of serum BDNF were detected in a subgroup of subjects with hypocortisolemia. Moreover, at baseline we found a negative correlation between BDNF and serum cortisol in volunteers with eucortisolemia. After treatment (D2) we observed higher BDNF levels in both patients and controls that ingested ayahuasca (N = 35) when compared to placebo (N = 34). Furthermore, at D2 just patients treated with ayahuasca (N = 14), and not with placebo (N = 14), presented a significant negative correlation between serum BDNF levels and depressive symptoms. This is the first double-blind randomized placebo-controlled clinical trial that explored the modulation of BDNF in response to a psychedelic in patients with depression. The results suggest a potential link between the observed antidepressant effects of ayahuasca and changes in serum BDNF, which contributes to the emerging view of using psychedelics as an antidepressant. This trial is registered at http://clinicaltrials.gov (NCT02914769).
Natural and experimental evidence drives marmosets for research on psychiatric disorders related to stress
(Frontiers Media SA, 2021-06-11) Sousa, Maria Bernardete Cordeiro de; Grilo, Maria Lara Porpino de Meiroz; Galvão-Coelho, Nicole Leite
Knowledge of the behavioral ecology of marmosets carried out in their natural habitat associated with the advent of a non-invasive technique for measuring steroid hormones in feces has made a significant contribution to understanding their social relationships and sexual strategies. These studies showed that they are mainly monogamous, live in relatively stable social groups according to a social hierarchy in which females compete and males cooperate, and form social bonds similar to humans, which makes this species a potential animal model to study disorders related to social stress. In addition, laboratory studies observed the expression of behaviors similar to those in nature and deepened the descriptions of their social and reproductive strategies. They also characterized their responses to the challenge using behavioral, cognitive, physiological, and genetic approaches that were sexually dimorphic and influenced by age and social context. These findings, added to some advantages which indicate good adaptation to captivity and the benefits of the birth of twins, small size, and life cycle in comparison to primates of the Old World, led to their use as animal models for validating psychiatric diseases such as major depression. Juvenile marmosets have recently been used to develop a depression model and to test a psychedelic brew called Ayahuasca from the Amazon rainforest as an alternative treatment for major depression, for which positive results have been found which encourage further studies in adolescents. Therefore, we will review the experimental evidence obtained so far and discuss the extension of the marmoset as an animal model for depression
Pathophysiology of major depression by clinical stages
(Frontiers Media SA, 2021-08-05) Galvão, Ana Cecília de Menezes; Almeida, Raíssa Nobrega; Sousa Júnior, Geovan Menezes de; Miguel, Mario André Leocadio; Fontes, Fernanda Palhano Xavier de; Araujo, Draulio Barros de; Soares, Bruno Lobão; Oliveira, João Paulo Maia de; Nunes, Emerson Arcoverde; Hallak, Jaime Eduardo Cecilio; Schuch, Felipe Barreto; Sarris, Jerome; Galvão-Coelho, Nicole Leite
The comprehension of the pathophysiology of the major depressive disorder (MDD) is essential to the strengthening of precision psychiatry. In order to determine the relationship between the pathophysiology of the MDD and its clinical progression, analyzed by severity of the depressive symptoms and sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including the levels of plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), serum cortisol (SC), and salivary cortisol awakening response (CAR), of patients with MDD (n = 58) and a control group of healthy volunteers (n = 62). Patients with the first episode of MDD (n = 30) had significantly higher levels of CAR and SC than controls (n = 32) and similar levels of mBDNF of controls. Patients with treatment-resistant depression (TRD, n = 28) presented significantly lower levels of SC and CAR, and higher levels of mBDNF and CRP than controls (n = 30). An increased severity of depressive symptoms and worse sleep quality were correlated with levels low of SC and CAR, and with high levels of mBDNF. These results point out a strong relationship between the stages clinical of MDD and changes in a range of relevant biological markers. This can assist in the development of precision psychiatry and future research on the biological tests for depression
Personality traits modulate stress responses after enclosure change of captive capuchin monkeys (Sapajus libidinosus)
(Elsevier BV, 2020-09-22) Ferreira, Vitor Hugo Bessa; Fonseca, Elanne De Paiva; Chagas, Ana Cecilia Correia Santos das; Pinheiro, Luiz Guilherme Mesquita; Sousa, Maria Bernardete Cordeiro de; Silva, Hélderes Peregrino Alves da; Galvão-Coelho, Nicole Leite; Ferreira, Renata Gonçalves
Husbandry procedures may cause behavioral and physiological changes to animals living in captivity. However, an individual’s reaction is not uniform and may be related to different coping strategies. In this study, we analyzed whether and how 12 adult captive capuchin monkeys (Sapajus libidinosus) varying in four personality axes (‘Feeding’, ‘Sociability’, ‘Exploration’, and ‘Activity’) differed in their stress responses to an enclosure change. Behavioral data and fecal samples of the individuals were collected for two months before (97 h and 246 fecal samples) and 14 days after the enclosure change (52 h and 666 fecal samples). We used Akaike Information Criteria to select the best linear regression models having personality axes and the period after enclosure change as predictive factors and behaviors potentially indicative of stress (BPIS) and levels of fecal glucocorticoid metabolites (FGM) as the response variables. Best models indicate that specific personality axes acted as a buffer and improved individual stress coping, mainly at the physiological level. More sociable and more active individuals did not show the peak of FGM levels as that exhibited by their less sociable and less active counterparts on the first day of the enclosure change. The link between exploration and resilience to acute stress was less clear: more exploratory individuals showed an increase in FGM levels during the first week of enclosure change, while the less exploratory ones showed a later increase, during the second-week post-enclosure change, suggesting a lesser capacity to recover from stressful stimuli in these individuals. The results presented in this study build on growing literature showing that animals differ in their behavioral profiles and that these differences relate to resilience to environmental disturbances, which may impact individual survival and reproduction, resulting in less genetic diversity of captive colonies and increased issues related to research replicability. We argue that these interindividual differences must be considered in husbandry decisions and during research data collection for the sake of animal welfare and reliable science
Physiological and behavioral responses to routine procedures in captive common marmosets (Callithrix jacchus)
(2016) Galvão, Ana Cecília de Menezes; Ferreira, Renata Gonçalves; Sousa, Maria Bernardete Cordeiro de; Galvão-Coelho, Nicole Leite
The effect of routine captive procedures on the welfare of species used as experimental models in biomedical research is of great interest, since stress may alter the generalization and interpretation of results. This study investigated behavioral and endocrine (fecal cortisol) reactivity patterns in common marmoset (Callithrix jacchus) adult males (N = 10) and females (N = 9) subjected to three types of routine procedures in captivity: (1) moving to a same-sized cage (P1), to a smaller cage (P2), and (2) first-time pair formation (P3). Sexually dimorphic cortisol responses were detected in animals submitted to a physical environmental stressor (cage change). Females showed an increased response throughout P1, in relation to baseline (BP) cortisol, and a trend during P2. Males increased cortisol only during P2. On the other hand, males and females showed a similar endocrine response when management involved social challenge (pair formation), with both sexes increasing cortisol levels, but females exhibited a more intense and longer-lasting cortisol increase. Males and females exhibited similar behavioral responses to cage change, except for autogrooming, with males decreasing this behavior in P1. Only females demonstrated a significantly higher increase in piloerection frequency than that of males during the pair formation phase. These endocrine and behavioral changes must be taken into account when interpreting research data that involve these types of procedures. Further studies on the impacts of routine colony management are required to devise and include protocols in official husbandry guidelines.
Potential biomarkers of major depression diagnosis and chronicity
(2021-09-29) Galvão, Ana Cecília de Menezes; Almeida, Raissa Nobrega; Sousa Júnior, Geovan Menezes de; Leocadio-Miguel, Mário André; Fontes, Fernanda Palhano Xavier de; Araujo, Draulio Barros de; Lobão-Soares, Bruno; Maia-de-Oliveira, João Paulo; Nunes, Emerson Arcoverde; Hallak, Jaime Eduardo Cecilio; Sarris, Jerome; Galvão-Coelho, Nicole Leite
Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve. For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p < 0.05) that discriminated between MD and TRD included four parameters, namely PSQI, CAR, SC, and mBDNF (AUC ROC = 0.99), with 96% of sensitivity and 93% of specificity. These results indicate that changes in specific biomarkers (CAR, SC, mBDNF and PSQI) have potential on the evaluation of MDD chronicity, but not for its diagnosis. Therefore, these findings can contribute for further studies aiming the development of a stronger model to be commercially available and used in psychiatry clinical practice
Resposta ao estresse: I. Homeostase e teoria da alostase
(2015) Sousa, Maria Bernardete Cordeiro de; Silva, Hélderes Peregrino A.; Galvão-Coelho, Nicole Leite
Os seres vivos desenvolvem ao longo de sua história evolutiva mecanismos de enfrentamento às condições adversas originadas tanto no ambiente geofísico como no ambiente social. Esta resposta adaptativa é coordenada e envolve diferentes sistemas funcionais, particularmente, os sistemas nervoso, endócrino e imune, e é denominada de resposta ao estresse e deve atender a duas demandas principais da vida: sobrevivência e reprodução. Esta revisão tem o objetivo de discutir o emprego do conceito clássico de homeostase e um conceito alternativo, alostase, que inclui os mecanismos preditivos e reativos de regulação, assim como os diferentes níveis de impacto dos estressores crônicos, resultando em sobrecarga alostática que pode ou não se seguir de falha alostática. Os mecanismos neurais, hormonais, imunes, sistêmicos e moleculares, que compreendem os sistemas alóstaticos subjacentes à resposta ao estresse são também apresentados.
Resposta ao estresse: II. Resiliência e vulnerabilidade
(2015) Galvão-Coelho, Nicole Leite; Silva, Hélderes Peregrino A.; Sousa, Maria Bernardete Cordeiro de
A crescente exposição a estressores na vida cotidiana aumentou significativamente a investigação da resposta ao estresse nas duas últimas décadas. Embora associada a consequências negativas, pois muitas patologias físicas e mentais são desencadeadas por exposição crônica a estressores, esta resposta é indispensável para sobrevivencia do indivíduo e é extremamente adaptativa quando ativada de forma aguda. Na parte I desta revisão foram abordados os conceitos de homestase e alostase e os sistemas fisiológicos ativados durante a resposta ao estresse. Na parte II serão discutidos fatores que modulam a resposta ao estresse tais como sexo, temperamento, períodos críticos do desenvolvimento e a presença ou ausência de suporte social. A interação entre os fatores genéticos e ambientais gera os perfis da resposta psicofisiológica que caracterizam os fenótipos de susceptibilidade e resiliência frente aos estressores e sua relação com uma patologia mental cada vez mais presente na sociedade moderna, o transtorno de estresse pós-traumático.
Social interactions and androgens levels in marmosets (Callithrix jacchus) in field and laboratory studies: a preliminary investigation of the Challenge Hypothesis
(2018) Sousa, Maria Bernardete Cordeiro de; Pontes, Mariana Chiste; Galvão, Ana Cecília de Menezes; Silva, Hélderes Peregrino Alves da; Galvão-Coelho, Nicole Leite
Not applicable.

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Navegando por Autor "Galvão-Coelho, Nicole Leite"